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Perspective Research on Antimicrobial Activities of Metals and Metal-Based Compounds
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Perspective Research on Antimicrobial Activities of Metals and Metal-Based Compounds

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: 15 June 2024 | Viewed by 1134

Special Issue Editor

Prof. Dr. Christopher Rensing

E-Mail Website
Guest Editor
College of Resources and Environment, Fujian Agriculture and Forestry University, Fuzhou 350002, China
Interests: Klebsiella; metal-microbe interactions; co-selection; virulence
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Microbes have a love–hate relationship with metals. Some metals may be essential to microbe survival, but they are toxic in certain forms and concentrations. In recent years, the antimicrobial resistance of metal ions has received more and more attention. Some metal-based nanoparticles have a non-specific bacterial toxicity mechanism, which makes it difficult for bacteria to develop drug resistance and also broadens the spectrum of antibacterial activity.

This current Special Issue of the International Journal of Molecular Sciences focuses on advances in the development of metalloantibiotics, uses of metal complexes to combat bacterial infections, analysis of antibiofilm properties of various metal oxide nanoparticles and nanocomposites, and the latest updates in this growing field. We welcome original scientific research articles, comprehensive reviews, and communications related to this topic.

Prof. Dr. Christopher Rensing
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metal-based nanoparticles
  • antibiotics
  • nanomedicine
  • mechanism of antibacterial activity

Published Papers (1 paper)

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Research

10 pages, 3409 KiB  
Communication
Polyoxometalate K6[P2Mo18O62] Inactivates Escherichia coli O157:H7 by Inducing recA Expression and Apoptosis-like Bacterial Death
by Shaoling Lin, Zhongjing Lin, Feng Zhou, Dehua Wang, Baodong Zheng and Jiamiao Hu
Int. J. Mol. Sci. 2023, 24(14), 11469; https://doi.org/10.3390/ijms241411469 - 14 Jul 2023
Viewed by 878
Abstract
Polyoxometalates have emerged as promising bactericidal agents. In the current study, the bactericidal activity of polyoxometalate K6[P2Mo18O62] against Escherichia coli (E. coli) O157:H7 and its possible underlying mechanisms were explored. The obtained results [...] Read more.
Polyoxometalates have emerged as promising bactericidal agents. In the current study, the bactericidal activity of polyoxometalate K6[P2Mo18O62] against Escherichia coli (E. coli) O157:H7 and its possible underlying mechanisms were explored. The obtained results demonstrated that K6[P2Mo18O62] could effectively kill E. coli O157:H7 at millimolar levels. Moreover, K6[P2Mo18O62] treatment also induced significant increases in recA protein expression and further triggered characteristic apoptosis-like bacterial death events such as DNA fragmentation and phosphatidylserine exposure. In conclusion, polyoxometalate K6[P2Mo18O62] possesses a desirable antibacterial activity, and induction of bacterial apoptosis-like death might be involved in its underlying bactericidal mechanisms. Full article
(This article belongs to the Special Issue Perspective Research on Antimicrobial Activities of Metals and Metal-Based Compounds)
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