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The Research about Cytomegalovirus (CMV)
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The Research about Cytomegalovirus (CMV)

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: closed (12 January 2024) | Viewed by 4619

Special Issue Editor

Dr. Pilar Pérez Romero

E-Mail Website
Guest Editor
Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, 28220 Madrid, Spain
Interests: cytomegalovirus; CMV genome; T-cell immune response; neutralizing antibodies; vaccine design
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cytomegalovirus (CMV) infection continues to be an important cause of morbidity, especially in individuals with an immature or dysfunctional immune system who develop complications associated with the infection, resulting in an important public health issue. In addition to the number of groups trying to understand the dynamics of CMV infection, the complex interaction between CMV and the immune system, the absence of an animal model that is able to reproduce the human physiology associated with CMV, and the lack of information on many of the potential proteins encoded by the CMV genome have limited our knowledge about virus–host interactions.

This Special Issue will focus on basic science and translational research to obtain complete comprehension of the CMV genome, the factors that contribute to the CMV virus–cell interaction, and tropism and implications for vaccine design.

Dr. Pilar Pérez Romero
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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Published Papers (3 papers)

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Research

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9 pages, 7417 KiB  
Communication
The Auditory Pathway in Congenitally Cytomegalovirus-Infected Human Fetuses
by Liliana Gabrielli, Maria Paola Bonasoni, Giulia Piccirilli, Evangelia Petrisli, Simona Venturoli, Alessia Cantiani, Matteo Pavoni, Concetta Marsico, Maria Grazia Capretti, Giuliana Simonazzi and Tiziana Lazzarotto
Int. J. Mol. Sci. 2024, 25(5), 2636; https://doi.org/10.3390/ijms25052636 - 24 Feb 2024
Cited by 1 | Viewed by 796
Abstract
Congenital cytomegalovirus (CMV) infection is the main cause of non-hereditary sensorineural hearing loss (SNHL). In order to shed light on SNHL pathophysiology, we examined the auditory pathway in CMV-infected fetuses; the temporal lobe, in particular the auditory cortex, and the inner ear. We [...] Read more.
Congenital cytomegalovirus (CMV) infection is the main cause of non-hereditary sensorineural hearing loss (SNHL). In order to shed light on SNHL pathophysiology, we examined the auditory pathway in CMV-infected fetuses; the temporal lobe, in particular the auditory cortex, and the inner ear. We investigated both inner ears and temporal lobes of 20 human CMV-infected fetuses at 21 weeks of gestation. As a negative group, five fetuses from spontaneous miscarriages without CMV infection were studied. Inner ears and temporal lobes were histologically examined, immunohistochemistry for CMV and CMV-PCR were performed. On the auditory cortex, we evaluated the local microglial reaction to the infection. CMV-positive cells were found in 14/20 brains and the damage was classified as severe, moderate, or mild, according to histological features. Fetuses with severe brain damage had a statistically higher temporal lobe viral load and a higher number of activated microglial cells in the auditory cortex compared to fetuses with mild brain damage (p: 0.01; p: 0.01). In the inner ears, the marginal cells of the stria vascularis were the most CMV positive. In our study, CMV affected the auditory pathway, suggesting a tropism for this route. In addition, in the auditory cortex, microglial activation may favor further tissue damage contributing to hearing loss. Full article
(This article belongs to the Special Issue The Research about Cytomegalovirus (CMV))
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Review

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27 pages, 2709 KiB  
Review
Immunosenescence and Cytomegalovirus: Exploring Their Connection in the Context of Aging, Health, and Disease
by Ludmila Müller and Svetlana Di Benedetto
Int. J. Mol. Sci. 2024, 25(2), 753; https://doi.org/10.3390/ijms25020753 - 6 Jan 2024
Viewed by 2448
Abstract
Aging induces numerous physiological alterations, with immunosenescence emerging as a pivotal factor. This phenomenon has attracted both researchers and clinicians, prompting profound questions about its implications for health and disease. Among the contributing factors, one intriguing actor in this complex interplay is human [...] Read more.
Aging induces numerous physiological alterations, with immunosenescence emerging as a pivotal factor. This phenomenon has attracted both researchers and clinicians, prompting profound questions about its implications for health and disease. Among the contributing factors, one intriguing actor in this complex interplay is human cytomegalovirus (CMV), a member of the herpesvirus family. Latent CMV infection exerts a profound influence on the aging immune system, potentially contributing to age-related diseases. This review delves into the intricate relationship between immunosenescence and CMV, revealing how chronic viral infection impacts the aging immune landscape. We explore the mechanisms through which CMV can impact both the composition and functionality of immune cell populations and induce shifts in inflammatory profiles with aging. Moreover, we examine the potential role of CMV in pathologies such as cardiovascular diseases, cancer, neurodegenerative disorders, COVID-19, and Long COVID. This review underlines the importance of understanding the complex interplay between immunosenescence and CMV. It offers insights into the pathophysiology of aging and age-associated diseases, as well as COVID-19 outcomes among the elderly. By unraveling the connections between immunosenescence and CMV, we gain a deeper understanding of aging’s remarkable journey and the profound role that viral infections play in transforming the human immune system. Full article
(This article belongs to the Special Issue The Research about Cytomegalovirus (CMV))
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Other

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13 pages, 2409 KiB  
Brief Report
Re-Analysis of the Widely Used Recombinant Murine Cytomegalovirus MCMV-m157luc Derived from the Bacmid pSM3fr Confirms Its Hybrid Nature
by Arne Cordsmeier, Christopher Bednar, Sabrina Kübel, Larissa Bauer and Armin Ensser
Int. J. Mol. Sci. 2023, 24(18), 14102; https://doi.org/10.3390/ijms241814102 - 14 Sep 2023
Cited by 1 | Viewed by 782
Abstract
Murine cytomegalovirus (MCMV), and, in particular, recombinant virus derived from MCMV-bacmid pSM3fr, is widely used as the small animal infection model for human cytomegalovirus (HCMV). We sequenced the complete genomes of MCMV strains and recombinants for quality control. However, we noticed deviances from [...] Read more.
Murine cytomegalovirus (MCMV), and, in particular, recombinant virus derived from MCMV-bacmid pSM3fr, is widely used as the small animal infection model for human cytomegalovirus (HCMV). We sequenced the complete genomes of MCMV strains and recombinants for quality control. However, we noticed deviances from the deposited reference sequences of MCMV-bacmid pSM3fr. This prompted us to re-analyze pSM3fr and reannotate the reference sequence, as well as that for the commonly used MCMV-m157luc reporter virus. A correct reference sequence for this frequently used pSM3fr, containing a repaired version of m129 (MCK-2) and the luciferase gene instead of ORF m157, was constructed. The new reference also contains the original bacmid sequence, and it has a hybrid origin from MCMV strains Smith and K181. Full article
(This article belongs to the Special Issue The Research about Cytomegalovirus (CMV))
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