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Reproductive-Related Disorders: Molecular Pathogenesis, Diagnosis and Treatment
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Reproductive-Related Disorders: Molecular Pathogenesis, Diagnosis and Treatment

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 30 July 2024 | Viewed by 1505

Special Issue Editors

Dr. Gulfam Ahmad

E-Mail Website
Guest Editor
1. Redox Biology Group, Charles Perkins Centre, Faculty of Medicine and Health, School of Medical Sciences, The University of Sydney, Sydney, NSW 2006, Australia
2. Andrology Department, Royal Women’s and Children’s Pathology, Carlton, VIC 3053, Australia
Interests: sperm; DNA; reproduction; ART; physiology; embryo
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Paul K. Witting

E-Mail Website
Guest Editor
Discipline of Pathology, The University of Sydney, Sydney, NSW 2006, Australia
Interests: vascular biology; nitric oxide; biomarkers of oxidative damage
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Deal Colleagues,

Reproductive disorders affect millions of people each year, irrespective of gender. The severity of these disorders varies, and prognosis depends on the underlying cause of the disease, which requires precise diagnosis for future treatment management. The diagnostic techniques and approaches to management also vary with an ongoing effort to discover, test, and commercialise more robust and sophisticated tools. Early screening and timely diagnosis can change the course of the disease. The current Special Issue, “Reproductive-Related Disorders: Molecular Pathogenesis, Diagnosis and Treatment”, considers the latest research on the disease pathophysiology, strategies, and innovative diagnostic techniques and proposed therapeutic measures targeting contemporary molecular pathways that can help cure both male and female reproductive disorders.

Dr. Gulfam Ahmad
Prof. Dr. Paul K. Witting
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • reproductive
  • gender
  • male
  • female
  • diseases
 

Published Papers (1 paper)

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Research

12 pages, 2466 KiB  
Article
Prefoldin-5 Expression Is Elevated in Eutopic and Ectopic Endometriotic Epithelium and Modulates Endometriotic Epithelial Cell Proliferation and Migration In Vitro
by Warren B. Nothnick, Wei Cui, Tommaso Falcone and Amanda Graham
Int. J. Mol. Sci. 2024, 25(4), 2390; https://doi.org/10.3390/ijms25042390 - 17 Feb 2024
Viewed by 890
Abstract
Endometriosis is a common disease among women of reproductive age in which endometrial tissue grows in ectopic localizations, primarily within the pelvic cavity. These ectopic “lesions” grow as well as migrate and invade underlying tissues. Despite the prevalence of the disease, an understanding [...] Read more.
Endometriosis is a common disease among women of reproductive age in which endometrial tissue grows in ectopic localizations, primarily within the pelvic cavity. These ectopic “lesions” grow as well as migrate and invade underlying tissues. Despite the prevalence of the disease, an understanding of factors that contribute to these cellular attributes remains poorly understood. Prefoldin-5 (PFDN5) has been associated with both aberrant cell proliferation and migration, but a potential role in endometriosis is unknown. As such, the purpose of this study was to examine PFDN5 expression in endometriotic tissue. PFDN5 mRNA and protein were examined in ectopic (lesion) and eutopic endometrial tissue from women with endometriosis and in eutopic endometrium from those without endometriosis using qRT-PCR and immunohistochemistry, respectively, while function of PFDN5 in vitro was evaluated using cell count and migration assays. PFDN5 mRNA and protein were expressed in eutopic and ectopic endometrial tissue, predominantly in the glandular epithelium, but not in endometrium from control subjects. Expression of both mRNA and protein was variable among endometriotic eutopic and ectopic endometrial tissue but showed an overall net increase. Knockdown of PFDN5 by siRNA transfection of endometriotic epithelial 12Z cells was associated with reduced cell proliferation/survival and migration. PFDN5 is expressed in eutopic and ectopic glandular epithelium and may play a role in proliferation and migration of these cells contributing to disease pathophysiology. Full article
(This article belongs to the Special Issue Reproductive-Related Disorders: Molecular Pathogenesis, Diagnosis and Treatment)
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