Effects of Environmental Contaminants on Cell Signaling Pathways
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 25 June 2024 | Viewed by 1036
Special Issue Editor
Special Issue Information
Dear Colleagues,
This Special Issue will focus on the effects of environmental contaminants on cell signaling pathways. The normal development of an organism begins at embryogenesis and continues through fetal, neonatal, and adolescent development, and the maintenance of adult tissues requires a delicate balance of a complex set of intra-, inter-, and extracellular-communication mechanisms controlling gene expression. The interruption of these cell communication systems by environmental contaminants results in growth and development pathologies. Within a tissue, cells typically function as communities, often termed syncytia, in which intercellular communication through gap junctions is pivotal in coordinating the intracellular signaling pathways controlling gene expression that maintains a balance between proliferation, differentiation, and apoptosis. Understanding the molecular basis by which environmental contaminants alter these pathways, particularly the central role gap junctions play in this process, will provide a more accurate mechanistic understanding of the pathologies of environmental toxicants.
Dr. Brad L. Upham
Guest Editor
Manuscript Submission Information
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Keywords
- cell signaling
- environmental contaminants
- signal transduction
- gap junction
- toxic mechanisms
