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Molecular Regulatory Mechanisms of Non-coding RNA in Cardiovascular Disease
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Molecular Regulatory Mechanisms of Non-coding RNA in Cardiovascular Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (25 March 2024) | Viewed by 2384

Special Issue Editors

Dr. Francesco Nappi

E-Mail
Guest Editor
Department of Cardiac Surgery, Centre Cardiologique du Nord, 93200 Saint-Denis, France
Interests: valve surgery; coronary surgery; aortic surgery; cardiac biomechanics; tissue biomodelling; tissue engineering; regenerative medicine
Special Issues, Collections and Topics in MDPI journals
Dr. Sanjeet Avtaar Singh

E-Mail Website
Guest Editor
Department of Cardiothoracic Surgery, Royal Infirmary of Edinburgh, Edinburgh EH16 4SA, UK
Interests: cardiac surgery

Special Issue Information

Dear Colleagues,

Research advances have highlighted the significant role of non-coding RNA (ncRNA) in cardiovascular disease and heart conditions. Specific long non-coding RNAs (lncRNAs) are closely associated with heart diseases like myocardial infarction and heart failure. MicroRNAs (miRNAs) regulate gene expression and impact cardiac cell proliferation and apoptosis in cardiovascular disease. Circular RNAs (circRNAs) act as miRNA sponges and modulate miRNA activity in heart diseases. Additionally, other ncRNAs, such as long non-coding circular RNAs (lncircRNAs) and transcription start site-associated RNAs (TSSRNAs), are implicated in cardiovascular disease. Dysregulated miRNAs are also linked to aortic dissection, degenerative mitral disease, aortic valve stenosis, heart tumors, and NSTEMI. Understanding the functions of ncRNAs and miRNAs in these conditions could improve diagnostics and targeted therapies for cardiovascular diseases.

Furthermore, the discovery of miRNA-associated extracellular vesicles, also known as miRNA-NETs, has provided new insights into the intercellular communication and pathogenesis of cardiovascular diseases. These vesicles contain miRNAs that can be released by various cell types, including platelets and endothelial cells, in response to injury or stress. MiRNA-NETs have been found to play a crucial role in modulating inflammation, thrombosis, and endothelial dysfunction, which are key processes involved in the development and progression of cardiovascular diseases such as atherosclerosis and myocardial infarction. Understanding the complex interactions between miRNA-NETs and target cells in the cardiovascular system holds great potential for the development of novel therapeutic strategies and diagnostic approaches. Further research in this area will deepen our understanding of the role of miRNA-NETs in cardiovascular diseases and pave the way for personalized medicine approaches in the management of these conditions.

Dr. Francesco Nappi
Dr. Sanjeet Avtaar Singh
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • non-coding RNA
  • cardiovascular disease
  • molecular regulation
  • lncRNA
  • miRNA
  • circRNA
  • gene expression
  • pathogenesis
  • heart disease
  • therapeutic targets

Published Papers (2 papers)

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Review

23 pages, 670 KiB  
Review
miRNAs in Heart Development and Disease
by Estefania Lozano-Velasco, José Manuel Inácio, Inês Sousa, Ana Rita Guimarães, Diego Franco, Gabriela Moura and José António Belo
Int. J. Mol. Sci. 2024, 25(3), 1673; https://doi.org/10.3390/ijms25031673 - 30 Jan 2024
Cited by 1 | Viewed by 1111
Abstract
Cardiovascular diseases (CVD) are a group of disorders that affect the heart and blood vessels. They include conditions such as myocardial infarction, coronary artery disease, heart failure, arrhythmia, and congenital heart defects. CVDs are the leading cause of death worldwide. Therefore, new medical [...] Read more.
Cardiovascular diseases (CVD) are a group of disorders that affect the heart and blood vessels. They include conditions such as myocardial infarction, coronary artery disease, heart failure, arrhythmia, and congenital heart defects. CVDs are the leading cause of death worldwide. Therefore, new medical interventions that aim to prevent, treat, or manage CVDs are of prime importance. MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the posttranscriptional level and play important roles in various biological processes, including cardiac development, function, and disease. Moreover, miRNAs can also act as biomarkers and therapeutic targets. In order to identify and characterize miRNAs and their target genes, scientists take advantage of computational tools such as bioinformatic algorithms, which can also assist in analyzing miRNA expression profiles, functions, and interactions in different cardiac conditions. Indeed, the combination of miRNA research and bioinformatic algorithms has opened new avenues for understanding and treating CVDs. In this review, we summarize the current knowledge on the roles of miRNAs in cardiac development and CVDs, discuss the challenges and opportunities, and provide some examples of recent bioinformatics for miRNA research in cardiovascular biology and medicine. Full article
(This article belongs to the Special Issue Molecular Regulatory Mechanisms of Non-coding RNA in Cardiovascular Disease)
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25 pages, 3065 KiB  
Review
The Roles of microRNAs in the Cardiovascular System
by Francesco Nappi, Sanjeet Singh Avtaar Singh, Vikram Jitendra, Almothana Alzamil and Thibaut Schoell
Int. J. Mol. Sci. 2023, 24(18), 14277; https://doi.org/10.3390/ijms241814277 - 19 Sep 2023
Cited by 1 | Viewed by 1059
Abstract
The discovery of miRNAs and their role in disease represent a significant breakthrough that has stimulated and propelled research on miRNAs as targets for diagnosis and therapy. Cardiovascular disease is an area where the restrictions of early diagnosis and conventional pharmacotherapy are evident [...] Read more.
The discovery of miRNAs and their role in disease represent a significant breakthrough that has stimulated and propelled research on miRNAs as targets for diagnosis and therapy. Cardiovascular disease is an area where the restrictions of early diagnosis and conventional pharmacotherapy are evident and deserve attention. Therefore, miRNA-based drugs have significant potential for development. Research and its application can make considerable progress, as seen in preclinical and clinical trials. The use of miRNAs is still experimental but has a promising role in diagnosing and predicting a variety of acute coronary syndrome presentations. Its use, either alone or in combination with currently available biomarkers, might be adopted soon, particularly if there is diagnostic ambiguity. In this review, we examine the current understanding of miRNAs as possible targets for diagnosis and treatment in the cardiovascular system. We report on recent advances in recognising and characterising miRNAs with a focus on clinical translation. The latest challenges and perspectives towards clinical application are discussed. Full article
(This article belongs to the Special Issue Molecular Regulatory Mechanisms of Non-coding RNA in Cardiovascular Disease)
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