Molecular Mechanisms of Angiogenesis
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 20 July 2024 | Viewed by 357
Special Issue Editor
Special Issue Information
Dear Colleagues,
Angiogenesis, the process of forming new blood vessels from pre-existing ones, is critically regulated by various factors, most importantly, vascular endothelial growth factor (VEGF). As such, VEGF was suggested for the treatment of coronary artery disease and peripheral arterial disease. Moreover, due to the role of VEGF in tumor vascularization, it was proposed that targeting VEGF or the cell membrane receptor tyrosine kinases it binds to would result in the inhibition of angiogenesis, ultimately counteracting tumor growth in humans. Furthermore, owing to similar reasoning, anti-VEGF drugs have been used for the treatment of neovascular age-related macular degeneration.
However, despite initial promise, these therapeutic approaches often fail to produce lasting clinical benefits, indicating that our current comprehension of the molecular processes underpinning angiogenesis remains incomplete.
This Special Issue of the International Journal of Molecular Sciences will consist of a compilation of research articles and reviews encompassing diverse facets of biochemistry and molecular biology pertaining to angiogenesis. Contributions on the cell signaling pathways involved, intracellular signal transduction dynamics and molecular characterization, as well as their potential impact on clinical outcomes, are encouraged. Studies on the setup of specific in vitro or in vivo models, including novel molecular biomarkers, will also be considered.
Dr. Edgar Delgado-Eckert
Guest Editor
Manuscript Submission Information
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Keywords
- angiogenesis
- VEGF
- intracellular signaling
- anti-angiogenic therapy for cancer
- artery disease
- age-related macular degeneration
