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Special Issue "Functional Role of Cytokines in Cancer and Chronic Inflammation"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 January 2024 | Viewed by 1005

Special Issue Editors

1. Department of Pediatric Surgery, Children's Hospital Inselspital, University of Bern, Freiburgstrasse 15, CH-3010 Bern, Switzerland
2. Department of Biomedical Research, University of Bern, Freiburgstrasse 15, CH-3010 Bern, Switzerland
Interests: cytokines; signaling pathway; checkpoint proteins; tumour biology
1. City Clinical Hospital Named After I.V. Davydovsky, Moscow Department of Healthcare, Moscow, Russia
2. Ministry of Healthcare, A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of the Russian Federation, Moscow, Russia
3. Department of Cell Biology and Histology, School of Biology, Lomonosov Moscow State University, Moscow, Russia
Interests: cytokines; inflammation; immune cells; cell migration; atherosclerosis

Special Issue Information

Dear Colleagues, 

Cytokines form a diverse group of signaling proteins which are secreted by a wide range of cell types, including immunocompetent cells, and contribute to various aspects of  inflammation, such as cell damage, metabolic alterations, angiogenesis, cell haemoattraction and migration. Beyond their more apparent role in acute inflammation, these molecules are responsible for a longstanding and less-studied chronic inflammatory response that is now known to drive a number of diseases, most notably a wide range of cancers, cardiovascular disease, and autoimmune and neurodegenerative disorders. Cytokines, which are involved in chronic inflammation, have specific effects on the cross-talk between various cell types and thus form a microenvironment that can either promote or block disease progression.

Over the last 30 years, the role of cytokines and their receptors have been extensively investigated in both cancer progression and anti-cancer therapy. However, more effective immunotherapies require the cytokine profiling of each tumour type and comprehensive understanding of tumour biology. In cardiovascular disease, cytokines are an important part of the atherogenic environment and thus appear as potential targets in atherosclerosis prevention and treatment.

The articles published in this Special Issue will cover all aspects of fundamental and translational cytokine research for better understanding of cancer development and chronic inflammation-related diseases. This includes pathogenesis, progression and cytokine-specific therapeutic approaches.

Dr. Elizaveta Fasler-Kan
Dr. Daria M. Potashnikova
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • cytokines
  • interleukins
  • cytokine antagonists
  • signaling pathways
  • chronic inflammation
  • immunometabolism
  • cancer development
  • cancer progression
  • immunotherapy
  • cytokine therapy

Published Papers (1 paper)

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Metabolic, Apoptotic and Fibro-Inflammatory Profiles of the Heart Exposed to Environmental Electromagnetic Fields
Int. J. Mol. Sci. 2023, 24(14), 11709; https://doi.org/10.3390/ijms241411709 - 20 Jul 2023
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Environmental stress can disturb the integrative functioning of the cardiovascular system and trigger a number of adaptive and/or maladaptive cell responses. Concomitant with the expanding use of mobile communication systems, public exposure to electromagnetic fields (EMFs) raises the question of the impact of [...] Read more.
Environmental stress can disturb the integrative functioning of the cardiovascular system and trigger a number of adaptive and/or maladaptive cell responses. Concomitant with the expanding use of mobile communication systems, public exposure to electromagnetic fields (EMFs) raises the question of the impact of 900 MHz EMFs on cardiovascular health. Therefore, in this study, we experimentally investigated whether 915 MHz EMF exposure influenced cardiac metabolic, antioxidant, apoptotic, and fibro-inflammatory profiles in a mouse model. Healthy mice were sham-exposed or exposed to EMF for 14 days. Western blot analysis using whole cardiac tissue lysates demonstrated that there was no significant change in the expression of oxidative phosphorylation (OXPHOS) complexes between the control and EMF-exposed mice. In addition, the myocardial expression of fibro-inflammatory cytokines, antioxidant enzymes, and apoptosis-related markers remained unchanged in the EMF-challenged hearts. Finally, the structural integrity of the cardiac tissues was preserved among the groups. These findings suggest that the apoptotic, antioxidant, metabolic, and fibro-inflammatory profiles of the heart remained stable under conditions of EMF exposure in the analyzed mice. Full article
(This article belongs to the Special Issue Functional Role of Cytokines in Cancer and Chronic Inflammation)
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