Molecular Research and Therapeutic Targets in Acute Settings: Ischemic and Traumatic Brain Injuries
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 30 July 2024 | Viewed by 979
Special Issue Editor
Special Issue Information
Dear Colleagues,
The pathophysiology of cerebral ischemia and brain trauma indicates that similar mechanisms contribute to the loss of cellular integrity and tissue damage.
Brain injuries result from the complex interplay of multiple pathways including excitotoxicity, ionic imbalance, oxidative/nitrative stress and blood–brain barrier (BBB) disruption. With cell type-specific pathomechanisms, acute cerebral insults activate neuronal cell death, inflammation from microglia activation and immune cell infiltration, accompanied with astrogliosis, and complex glia–neuron exchanges, and they are important elements in the pathological onset and the progression of ischemic or trauma-triggered brain damage.
From exploring these molecular mechanisms and dissecting the role of specific cell-type signaling pathways or cell–cell interactions, each contribution will aim to provide insights that pave the way for more effective therapeutic approaches.
I look forward to receiving your contributions.
Dr. Hylde Zirpoli
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- ischemic brain injury
- traumatic brain insult
- cell-type specific molecular mechanisms
- therapy
- target discovery
- repurposing
- efficacy studies
- new drug formulations
- high-throughput technologies
- proteomics
- metabolomics
- microarray
- next-generation sequencing
- BBB disruption
- gliosis
- neuronal loss
- neurobehavior
- age-related molecular mechanisms in brain injury
