Special Issue "Molecular and Cellular Mechanisms Underlying Taste, Smell and Beyond 2.0"
Deadline for manuscript submissions: 15 October 2023 | Viewed by 2293
Interests: taste receptor; taste preferences; feeding behavior; carbohydrate metabolism; adult stem cells
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Taste and smell are two basic senses that enable us to perceive external chemical stimuli. Over the past few decades, by using a variety of experimental models, significant progress has been made towards understanding the molecular, cellular, and circuit mechanisms that underly the perception of taste and olfactory stimuli, ranging from the detection of chemical stimuli by taste, olfactory receptors expressed in taste bud cells, or olfactory sensory neurons to the central information processing in the brain. Yet, many gaps still remain (e.g., how tastants or odorants bind to and activate taste or olfactory receptors; how different brain regions encode the sensory information). Unique to the gustatory and olfactory sensory systems, taste organs and the olfactory epithelium regenerate throughout life. Senescent taste receptor cells or olfactory sensory neurons are replaced by newborn cells generated from adult taste or olfactory stem cells. Recent advances in the relevant fields start to illustrate these processes in detail. Chemosensory signaling elements are not restricted to peripheral taste or olfactory tissues. Emerging evidence demonstrates that they may have key functions in many types of cells outside of the oral and nasal cavities. This brings a new perspective to chemosensory research. In addition to their classical roles in sensing chemicals and triggering behavioral responses, such as the ingestion or rejection of particular foods, taste and smell can also influence many other aspects of physiology. Taste and smell are often understudied in the area of pathophysiology. Yet, many people with COVID-19 suffer from a loss of taste and smell. This can directly impact quality of life and wellness. Understanding taste and smell dysfunction and development of effective treatments are clearly needed. In this research topic, we welcome original research articles and review articles relating to the broader aspect of taste and smell research to help advance the research on chemical senses.
Dr. Peihua Jiang
Manuscript Submission Information
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- taste receptor
- taste preferences
- feeding behavior
- carbohydrate metabolism
- adult stem cells