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Bioactive Compounds for the Prevention and Treatment of Human Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 30 April 2024 | Viewed by 884

Special Issue Editor


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Guest Editor
Department of Gynecological Oncology and Gynecology, Medical University of Lublin, Lublin, Poland
Interests: gynecology; cancer

Special Issue Information

Dear Colleagues,

The health benefits deriving from the nature have been common knowledge since ancient times. So far, many bioactive compounds which vary widely in chemical structure and function, have been discovered.

It is assumed that approximately 80% of active compounds obtained from natural sources are used in medicine. Several substances possessed from plants, fruits, vegetables, fish and microorganisms have anti-inflammatory, antioxidative, neuroprotective and anticancer effects.

These promising activities should be elucidated in vitro, in cells, and also in clinical trials. Biological mechanisms of action, or bioactivity of these metabolites are also required to establish their real contribution to the health status.

The aim of this Special Issue is to attract original research articles and review articles describing the current findings concerning therapeutic potential of bioactive compounds; as regulators of cancer,therapeutic agents in controlling human diseases,regulators of pro- /anti-inflammatory and immunological pathways.

Dr. Marek Gogacz
Guest Editor

Manuscript Submission Information

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Keywords

  • bioactive compounds
  • antioxidant activity
  • inflammation
  • natural plants and products
  • macro and microelements
  • vitamins
  • immune system
  • health benefits
  • anticancer activity
  • disease prevention

Published Papers (1 paper)

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Research

28 pages, 4001 KiB  
Article
Tetraselmis chuii Edible Microalga as a New Source of Neuroprotective Compounds Obtained Using Fast Biosolvent Extraction
by Melis Cokdinleyen, Gerardo Alvarez-Rivera, Jose Luis González Tejera, José A. Mendiola, Alberto Valdés, Huseyin Kara, Elena Ibáñez and Alejandro Cifuentes
Int. J. Mol. Sci. 2024, 25(7), 3897; https://doi.org/10.3390/ijms25073897 - 31 Mar 2024
Viewed by 623
Abstract
Tetraselmis chuii is an EFSA-approved novel food and dietary supplement with increasing use in nutraceutical production worldwide. This study investigated the neuroprotective potential of bioactive compounds extracted from T. chuii using green biobased solvents (ethyl acetate, AcOEt, and cyclopentyl methyl ether, CPME) under [...] Read more.
Tetraselmis chuii is an EFSA-approved novel food and dietary supplement with increasing use in nutraceutical production worldwide. This study investigated the neuroprotective potential of bioactive compounds extracted from T. chuii using green biobased solvents (ethyl acetate, AcOEt, and cyclopentyl methyl ether, CPME) under pressurized liquid extraction (PLE) conditions and supercritical fluid extraction (SFE). Response surface optimization was used to study the effect of temperature and solvent composition on the neuroprotective properties of the PLE extracts, including anticholinergic activity, reactive oxygen/nitrogen species (ROS/RNS) scavenging capacity, and anti-inflammatory activity. Optimized extraction conditions of 40 °C and 34.9% AcOEt in CPME resulted in extracts with high anticholinergic and ROS/RNS scavenging capacity, while operation at 180 °C and 54.1% AcOEt in CPME yielded extracts with potent anti-inflammatory properties using only 20 min. Chemical characterization revealed the presence of carotenoids (neoxanthin, violaxanthin, zeaxanthin, α- and β-carotene) known for their anti-cholinesterase, antioxidant, and anti-inflammatory potential. The extracts also exhibited high levels of omega-3 polyunsaturated fatty acids (PUFAs) with a favorable ω-3/ω-6 ratio (>7), contributing to their neuroprotective and anti-inflammatory effects. Furthermore, the extracts were found to be safe to use, as cytotoxicity assays showed no observed toxicity in HK-2 and THP-1 cell lines at or below a concentration of 40 μg mL−1. These results highlight the neuroprotective potential of Tetraselmis chuii extracts, making them valuable in the field of nutraceutical production and emphasize the interest of studying new green solvents as alternatives to conventional toxic solvents. Full article
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