Plasticity of the Nervous System after Injury 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 30 May 2024 | Viewed by 495
Special Issue Editors
Interests: nerve injuries; regeneration; neural plasticity; axonal regeneration
Interests: nerve injuries; regeneration; neural plasticity; axonal regeneration
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Functional recovery is too often poor after peripheral nerve injuries. This is in spite of the capacity of supporting glial cells, the Schwann cells that myelinate the axons, to support the regeneration of the injured axons and to reinnervate their target muscle and sense organs. Recovery of function is even more severely limited in the central nervous system. This is due to the inability of the glial cells, oligodendrocytes, to support the growth of central axons. Studies regarding peripheral nerve injuries are revealing recovery mechanisms and novel methodologies to promote functional motor and sensory recovery. These include the activation of intrinsic growth pathways, as well as the use of brief low-frequency electrical stimulation, intermittent hypoxia, bioluminescent optogenetics, optimized nerve grafts and nerve transfers, stem cells, and manufactured Schwann cells for nerve repair. The dynamics of plasticity after spinal cord injuries and the relevance of locomotor networks in restoring function provide a means to restore function after central nerve injuries.
Prof. Dr. Xavier Navarro
Prof. Dr. Tessa Gordon
Guest Editors
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Keywords
- neural plasticity
- axonal regeneration
- nerve injury
- glial cells
- central nervous system
