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Advances in Plant Physiology, Biochemistry, and Biotechnology for Natural Product Synthesis

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Plant Sciences".

Deadline for manuscript submissions: 20 May 2024 | Viewed by 988

Special Issue Editor


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Guest Editor
1. LEAF, Linking Landscape, Environment, Agriculture and Food (LEAF), Departmento de Recursos Biológicos, Ambiente e Território (DRAT), Instituto Superior de Agronomia, Universidade de Lisboa, Tapada da Ajuda, 1349-017 Lisboa, Portugal
2. Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisbon, Portugal
Interests: plant physiology; plant molecular biology; plant biochemistry; medicinal plants; natural products; plant membrane transporters; abiotic stress
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Special Issue Information

Dear Colleagues,

The plant kingdom represents an immense reservoir of pharmacologically active compounds. Plants produce a broad array of secondary metabolites, and plant-derived compounds have been of human interest for centuries as flavours, fragrances, dyes, pesticides, and pharmaceuticals. They can be utilized—either in their original or semi-synthetic states. Presently, these natural products are mainly extracted from wild or cultivated plants in order to supply phytomolecules on demand. However, due to climate change, numerous environmental factors like drought, salinity, temperature, and heavy metals now affect the physiology and biochemistry of plants, eventually impeding the biosynthesis of their secondary metabolites. The biotechnological approach, centred upon utilizing plant cell cultures as green factories, is an attractive alternative. However, the lack of understanding of the biosynthetic pathways of many secondary metabolites limits the upscaling of their production at the cellular level. Recent advances in plant genomics and metabolite profiling offer tremendous prospects for exploring the complex biosynthesis of natural products to enhance their production and also produce value-added compounds. Additionally, utilizing combinatorial tools can also open the possibility of synthesizing rare and expensive natural products and generating entirely new compounds.

This Special Issue intends to emphasize recent research advances related to the production of secondary metabolites from medicinal plants. Specifically, this Issue will present studies dealing with physiological and biochemical changes of the medicinal plants under conditions of abiotic stress, various biotechnological approaches to enhancing the production of natural products. We welcome authors to submit original research articles, reviews, and short communications.

Dr. Farzana Sabir
Guest Editor

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Keywords

  • medicinal plants
  • natural products
  • phytomedicine

Published Papers (1 paper)

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Research

18 pages, 3379 KiB  
Article
Chemical Composition of Methanol Extracts from Leaves and Flowers of Anemonopsis macrophylla (Ranunculaceae)
by Vera A. Kostikova, Natalia V. Petrova, Alexander A. Chernonosov, Vladimir V. Koval, Evgeniia R. Kovaleva, Wei Wang and Andrey S. Erst
Int. J. Mol. Sci. 2024, 25(2), 989; https://doi.org/10.3390/ijms25020989 - 12 Jan 2024
Viewed by 745
Abstract
Anemonopsis Siebold et Zucc. is an unstudied single-species genus belonging to the tribe Cimicifugeae (Ranunculaceae). The only species of this genus—Anemonopsis macrophylla Siebold and Zucc.—is endemic to Japan. There are no data on its chemical composition. This work is the first to [...] Read more.
Anemonopsis Siebold et Zucc. is an unstudied single-species genus belonging to the tribe Cimicifugeae (Ranunculaceae). The only species of this genus—Anemonopsis macrophylla Siebold and Zucc.—is endemic to Japan. There are no data on its chemical composition. This work is the first to determine (with liquid chromatography–high-resolution mass spectrometry, LC-HRMS) the chemical composition of methanol extracts of leaves and flowers of A. macrophylla. More than 100 compounds were identified. In this plant, the classes of substances are coumarins (13 compounds), furocoumarins (3), furochromones (2), phenolic acids (21), flavonoids (27), and fatty acids and their derivatives (15 compounds). Isoferulic acid (detected in extracts from this plant) brings this species closer to plants of the genus Cimicifuga, one of the few genera containing this acid and ferulic acid at the same time. Isoferulic acid is regarded as a reference component of a quality indicator of Cimicifuga raw materials. The determined profiles of substances are identical between the leaf and flower methanol extracts. Differences in levels of some identified substances were revealed between the leaf and flower extracts of A. macrophylla; these differences may have a substantial impact on the manifestation of the biological and pharmacological effects of the extracts in question. Full article
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