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RNA Function and Structure
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RNA Function and Structure

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 30 April 2024 | Viewed by 1400

Special Issue Editor

Dr. Anna Wacker

E-Mail Website
Guest Editor
Schwalbe Lab, Institute for Organic Chemistry, Goethe University Frankfurt, Frankfurt, Germany
Interests: riboswitch RNA; RNA structural dynamics; variations of canonical RNA motifs; NMR spectroscopy of non-static RNA

Special Issue Information

Dear Colleagues,

As of the current moment, with the award of the Nobel Prize to Katalin Kariko, the realization has reached the general public that RNA provides valuable and diverse functions that we can and must harness. In order to build up a similar repertoire of tools and systems that have long existed for proteins, we need fundamental knowledge of the structural principles underlying the function of RNA. This Special Issue is dedicated to research on precisely this connection between RNA function and its structure. Both research articles and review papers are welcomed in the Special Issue.

Dr. Anna Wacker
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • RNA architecture
  • molecular motions
  • structural dynamics
  • NMR spectroscopy
  • RNA–RNA interaction
  • RNA-binding proteins
  • RNA–ligand complex
  • RNA recognition
  • RNA modifications
  • RNA targeting

Published Papers (1 paper)

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Review

16 pages, 1124 KiB  
Review
An Overview of Current Detection Methods for RNA Methylation
by Buket Sağlam and Bünyamin Akgül
Int. J. Mol. Sci. 2024, 25(6), 3098; https://doi.org/10.3390/ijms25063098 - 07 Mar 2024
Viewed by 1131
Abstract
Epitranscriptomic mechanisms, which constitute an important layer in post-transcriptional gene regulation, are involved in numerous cellular processes under health and disease such as stem cell development or cancer. Among various such mechanisms, RNA methylation is considered to have vital roles in eukaryotes primarily [...] Read more.
Epitranscriptomic mechanisms, which constitute an important layer in post-transcriptional gene regulation, are involved in numerous cellular processes under health and disease such as stem cell development or cancer. Among various such mechanisms, RNA methylation is considered to have vital roles in eukaryotes primarily due to its dynamic and reversible nature. There are numerous RNA methylations that include, but are not limited to, 2’-O-dimethyladenosine (m6Am), N7-methylguanosine (m7G), N6-methyladenosine (m6A) and N1-methyladenosine (m1A). These biochemical modifications modulate the fate of RNA by affecting the processes such as translation, target site determination, RNA processing, polyadenylation, splicing, structure, editing and stability. Thus, it is highly important to quantitatively measure the changes in RNA methylation marks to gain insight into cellular processes under health and disease. Although there are complicating challenges in identifying certain methylation marks genome wide, various methods have been developed recently to facilitate the quantitative measurement of methylated RNAs. To this end, the detection methods for RNA methylation can be classified in five categories such as antibody-based, digestion-based, ligation-based, hybridization-based or direct RNA-based methods. In this review, we have aimed to summarize our current understanding of the detection methods for RNA methylation, highlighting their advantages and disadvantages, along with the current challenges in the field. Full article
(This article belongs to the Special Issue RNA Function and Structure)
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