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Molecular Pharmacology and Metabolism of Phytochemicals

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".

Deadline for manuscript submissions: 15 May 2024 | Viewed by 1527

Special Issue Editor


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Guest Editor
Food and Bio-Industry Research Institute, School of Food Science & Biotechnology, College of Agriculture and Life Sciences, Kyungpook National University, Daegu 41566, Republic of Korea
Interests: phytochemicals; chemoprevention; antioxidant defences; anti-inflammation; hair growth; phase II enzymes; signal transduction
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Special Issue Information

Dear Colleagues,

Natural compounds are increasingly featured in medical treatments. Exogenous natural compounds are more likely to be used in this context, either alone or more commonly as supplements to traditional therapies. Phytochemicals, bioactive chemical compounds found in plants, have long been studied for their potential health benefits. Many phytochemicals have been shown to induce cellular defense mechanisms against exposure to various endogenous and exogenous toxicants as well as reactive oxygen and nitrogen species (ROS/RNS). Inhibition of pro-inflammatory and carcinogenic molecular targets is also a cellular defense strategy of phytochemicals to prevent chronic diseases and maintain health. Improving the gut microbiome profile with phytochemicals could be another recent approach to enhancing defense ability.

However, the pharmacology and metabolism of phytochemicals and other natural compounds are less studied and characterized, even though phytochemicals have been present in human biological systems for thousands of years. In this context, the pharmacology and metabolism of phytochemicals and other natural compounds are critical. Without addressing it, it could lead to unforeseen toxicity or treatment failure. On the contrary, with well-defined pharmacokinetics, pharmacodynamics, and metabolism (or biotransformation), natural compounds like phytochemicals can be applied more widely in medical and health conditions and used more properly to achieve better therapeutic outcomes, which will benefit patients.

This Special Issue calls for original research articles and reviews that address the progress and current understanding in the overlapping research topics of “Molecular Pharmacology and Metabolism of Phytochemicals”.

Prof. Dr. Woo-Sik Jeong
Guest Editor

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Keywords

  • phytochemicals
  • natural compounds
  • metabolism
  • antioxidant
  • anti-inflammation
  • pharmacokinetics
  • pharmacodynamics

Published Papers (1 paper)

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Research

19 pages, 2728 KiB  
Article
Anti-Inflammatory and Antioxidant Activities of Lipophilic Fraction from Liriope platyphylla Seeds Using Network Pharmacology, Molecular Docking, and In Vitro Experiments
by Van-Long Truong, Yeon-Ji Bae, Razanamanana H. G. Rarison, Ji-Hong Bang, So-Yoon Park and Woo-Sik Jeong
Int. J. Mol. Sci. 2023, 24(19), 14958; https://doi.org/10.3390/ijms241914958 - 06 Oct 2023
Viewed by 1230
Abstract
Antioxidant and anti-inflammatory mechanisms counteract the pathogenesis of chronic diseases, such as diabetes, aging, and cancer. Therefore, enhancing antioxidant and anti-inflammatory functions may help manage these pathological conditions. This study aimed to assess the antioxidant and anti-inflammatory potentials of lipophilic fraction of Liriope [...] Read more.
Antioxidant and anti-inflammatory mechanisms counteract the pathogenesis of chronic diseases, such as diabetes, aging, and cancer. Therefore, enhancing antioxidant and anti-inflammatory functions may help manage these pathological conditions. This study aimed to assess the antioxidant and anti-inflammatory potentials of lipophilic fraction of Liriope platyphylla seeds (LLPS) using network pharmacology, molecular docking, and in vitro experiments. Here GC–MS analysis tentatively identified forty-three lipophilic compounds in LLPS. LLPS exhibited powerful antioxidant activity, according to the results from chemical-based antioxidant assays on DPPH, ABTS+, superoxide anion, hydrogen peroxide, nitric oxide, and hydroxyl radicals scavenging, lipid peroxidation, reducing antioxidant powers, and total antioxidant capacity. Additionally, LLPS enhanced cellular antioxidant capacity by inhibiting reactive oxygen species formation and elevating antioxidant enzyme levels, including catalase and heme oxygenase-1. Moreover, LLPS attenuated inflammatory response by reducing nitric oxide secretion and downregulating the expression of inducible nitric oxide synthase, cyclooxygenase-2, and interleukin-1β in lipopolysaccharide-treated macrophages. Network pharmacology and molecular docking analyses showed that key compounds in LPPS, particularly phytosterols and fatty acid esters, exerted antioxidant and anti-inflammatory properties through regulating NFKB1, PTGS1, PTGS2, TLR4, PRKCA, PRKCD, KEAP1, NFE2L2, and NR1l2. Overall, these data suggest that LLPS may be a potential antioxidant and anti-inflammatory agent for developing functional foods. Full article
(This article belongs to the Special Issue Molecular Pharmacology and Metabolism of Phytochemicals)
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