Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
7.8
5.6
Journals
IJMS
Special Issues
The Role of Albumin in Tissue Regeneration and Repair
ijms-logo
Submit to Special Issue Submit Abstract to Special Issue Review for IJMS Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

The Role of Albumin in Tissue Regeneration and Repair

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 1398

Special Issue Editor

Dr. Denes B. Horvathy

E-Mail Website
Guest Editor
Department of Interventional Radiology, Semmelweis University, Budapest, Hungary
Interests: serum-albumin-based materials for bone tissue regeneration; navigations systems for CT-guided interventions; transarterial radioembolization
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Tissue regeneration and repair are essential processes in regenerative medicine, aiming to restore the structure and function of damaged tissues. Albumin exhibits excellent biocompatibility, biodegradability, and the ability to interact with cells and growth factors, making it an attractive choice for tissue engineering applications. Researchers have successfully engineered albumin-based scaffolds, nanoparticles, and hydrogels with tailored mechanical properties, controlled release kinetics, and the ability to support cell adhesion and proliferation. Moreover, in preclinical models, albumin-based systems have demonstrated the potential to promote tissue-specific cell differentiation, stimulate angiogenesis, and accelerate tissue regeneration. However, there are still important questions that need to be addressed. Such as the precise mechanisms by which albumin enhances tissue regeneration, the design and functionalization of albumin-based bioengineered materials, and the long-term stability, biocompatibility, and immune response of albumin-based constructs, to name a few. Addressing these gaps will pave the way for developing novel albumin-based bioengineered materials with enhanced regenerative capabilities, ultimately advancing the field of tissue regeneration and repair.

This Special Issue aims to demonstrate the recent developments of albumin-based biomaterials for tissue repair and regeneration applications. This Special Issue is open to both original papers and reviews. The topics of interest include but are not limited to:

  1. The underlying mechanisms, immunomodulatory properties, and pathways by which albumin enhances tissue regeneration.
  2. Fabrication techniques and modifications used to develop albumin-based materials for tissue regeneration.
  3. Novel-engineered materials utilizing albumin for tissue regeneration.
  4. Applications utilizing albumin-based materials.
  5. Future directions and challenges for the clinical translation of albumin-based materials.

Dr. Denes B. Horvathy
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • tissue regeneration
  • albumin
  • scaffolds
  • tissue engineering
  • albumin-based biomaterials
  • HAS
  • BSA

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

20 pages, 4180 KiB  
Article
The Thiol Group Reactivity and the Antioxidant Property of Human Serum Albumin Are Controlled by the Joint Action of Fatty Acids and Glucose Binding
by Tamara Uzelac, Katarina Smiljanić, Marija Takić, Ivana Šarac, Gordana Oggiano, Milan Nikolić and Vesna Jovanović
Int. J. Mol. Sci. 2024, 25(4), 2335; https://doi.org/10.3390/ijms25042335 - 16 Feb 2024
Viewed by 1059
Abstract
The binding of ubiquitous serum ligands (free fatty acids) to human serum albumin (HSA) or its glycation can affect thiol group reactivity, thus influencing its antioxidant activity. The effects of stearic acid (SA) and glucose binding on HSA structural changes and thiol group [...] Read more.
The binding of ubiquitous serum ligands (free fatty acids) to human serum albumin (HSA) or its glycation can affect thiol group reactivity, thus influencing its antioxidant activity. The effects of stearic acid (SA) and glucose binding on HSA structural changes and thiol group content and reactivity were monitored by fluoroscopy and the Ellman method during a 14-day incubation in molar ratios to HSA that mimic pathophysiological conditions. Upon incubation with 5 mM glucose, HSA glycation was the same as HSA without it, in three different HSA:SA molar ratios (HSA:SA-1:1-2-4). The protective effect of SA on the antioxidant property of HSA under different glucose regimes (5-10-20 mM) was significantly affected by molar ratios of HSA:SA. Thiol reactivity was fully restored with 5–20 mM glucose at a 1:1 HSA:SA ratio, while the highest thiol content recovery was in pathological glucose regimes at a 1:1 HSA:SA ratio. The SA affinity for HSA increased significantly (1.5- and 1.3-fold, p < 0.01) with 5 and 10 mM glucose compared to the control. These results deepen the knowledge about the possible regulation of the antioxidant role of HSA in diabetes and other pathophysiological conditions and enable the design of future HSA-drug studies which, in turn, is important for clinicians when designing information-based treatments. Full article
(This article belongs to the Special Issue The Role of Albumin in Tissue Regeneration and Repair)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop