Advancements in Mast Cell Activation and Respiratory Conditions Updates
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 20 June 2024 | Viewed by 463
Special Issue Editor
Interests: respiratory medicine; genetic epidemiology; immunology; human biology; genetics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue is supervised by Dr. Ramcés Falfán-Valencia and assisted by our Topical Advisory Panel members, Dr. Leslie Chávez-Galán and Dr. Espiridion Ramos-Martínez.
We are pleased to invite you to contribute to our Special Issue of the International Journal of Molecular Sciences (IJMS), titled “Activation and Modulation of Mast Cells. An Update on Respiratory Physiological and Pathological Conditions”. This issue will cover a selection of recent research topics and current review articles, reporting the latest updates on mast cells with a particular emphasis on the molecular mechanisms of their activation and the ensuing cellular responses in respiratory physiological and pathological conditions beyond asthma and allergy.
Mast cells (MCs) are highly granular tissue-resident cells from the innate immune and neuroimmune systems and are critical participants in allergy, anaphylaxis, and various other conditions. A growing understanding of the mechanisms and regulation of mast cell activation and disease pathogenesis has led to substantial progress in developing new disease treatment strategies. Furthermore, the interaction between resident microbiota and mast cells has been recently investigated, revealing a new level of interaction between mast cells and microorganisms that is of homeostatic relevance.
MCs can be activated by pathogens, including nematodes, bacteria, viruses, protozoa, and fungi, control the migration of antigen-presenting dendritic cells, or work as antigen-presenting cells, thus contributing to the initiation of innate immune and adaptive immune reactions. MCs are strategically located in different lung compartments and are recognized as central effectors and immunomodulators in many conditions. MC mediators activate a broad spectrum of cells of the innate and adaptive immune system during airway inflammation. Moreover, these cells modulate the activities of several structural cells, such as fibroblasts, airway smooth muscle cells, bronchial epithelial and goblet cells, and endothelial cells in the human lung.
Dr. Ramcés Falfán-Valencia
Guest Editor
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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Keywords
- mast cells
- immune protection
- inflammation
- intestinal microbiota
- genetic susceptibility
- respiratory exacerbation
- biomarkers
- anaphylaxis
- airway remodeling
- biomass-burning smoke
