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Sirtuins as Players in Cell Metabolism and Functions
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Sirtuins as Players in Cell Metabolism and Functions

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 15 May 2024 | Viewed by 2329

Special Issue Editors

Dr. Antonietta Santoro

E-Mail Website
Guest Editor
Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, 84081 Baronissi, Italy
Interests: the effects of environmental pollutants on human health; the role of the endocannabinoid system in the processes of carcinogenicity, inflammation, neurogenesis and neuronal differentiation
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Rosaria Meccariello

E-Mail Website
Guest Editor
Department of Movement and Wellness Sciences, Parthenope University of Naples, I-80133 Naples, Italy
Interests: endocannabinoid system; endocannabinoids–GnRH–steroids crosstalk; kisspeptins; reproduction; HPG axis; spermatogenesis; spermatozoa; endocrine disruptors; epigenetics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Sirtuins or silent information regulator 2 (SIR2) proteins are a family of deacetylases discovered in the 1970s in yeast. Since their discovery, sirtuins have been found in organisms ranging from bacteria to plants, and animals. Different forms of sirtuins are present in the cytoplasm, nucleus and mitochondria thus suggesting a key role for these proteins in regulating cell functions and metabolism. Sirtuins are also epigenetic erasers catalyzing post-translational deacetylation of other proteins in response to environmental cues, thus affecting gene silencing, cell survival, proliferation, and differentiation. Although the precise mechanisms of action of these proteins are still unknown, sirtuins’ dysregulation has been related to the pathogenesis of different diseases and new insights are emerging which suggest that sirtuins are involved in redox signaling, immunomodulation, neurodegeneration, aging, cancer, and reproduction. This highlights their potential to be targeted in pharmacological approaches based on sirtuins’ modulators. Therefore, this Special Issue welcomes comprehensive reviews and research papers which aim to provide an up-to-date report on the role of sirtuins in cell metabolism and functions with particular emphasis on molecular mechanisms and epigenetic effects in living organisms as well as their therapeutic potential in experimental model systems and humans.

Dr. Antonietta Santoro
Prof. Dr. Rosaria Meccariello
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • sirtuins
  • epigenetics effects
  • SIRT modulators
  • neurodegeneration
  • neuroprotection and neuroimmunology
  • control of reproduction
  • cell metabolism
  • ageing
  • immunomodulation

Published Papers (2 papers)

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Research

19 pages, 7304 KiB  
Article
Does Selection for Longevity in Acheta domesticus Involve Sirtuin Activity Modulation and Differential Response to Activators (Resveratrol and Nanodiamonds)?
by Patrycja Ziętara, Barbara Flasz and Maria Augustyniak
Int. J. Mol. Sci. 2024, 25(2), 1329; https://doi.org/10.3390/ijms25021329 - 22 Jan 2024
Viewed by 632
Abstract
Sirtuins, often called “longevity enzymes”, are pivotal in genome protection and DNA repair processes, offering insights into aging and longevity. This study delves into the potential impact of resveratrol (RV) and nanodiamonds (NDs) on sirtuin activity, focusing on two strains of house crickets [...] Read more.
Sirtuins, often called “longevity enzymes”, are pivotal in genome protection and DNA repair processes, offering insights into aging and longevity. This study delves into the potential impact of resveratrol (RV) and nanodiamonds (NDs) on sirtuin activity, focusing on two strains of house crickets (Acheta domesticus): the wild-type and long-lived strains. The general sirtuin activity was measured using colorimetric assays, while fluorescence assays assessed SIRT1 activity. Additionally, a DNA damage test and a Kaplan–Meier survival analysis were carried out. Experimental groups were fed diets containing either NDs or RV. Notably, the long-lived strain exhibited significantly higher sirtuin activity compared to the wild-type strain. Interestingly, this heightened sirtuin activity persisted even after exposure to RVs and NDs. These findings indicate that RV and NDs can potentially enhance sirtuin activity in house crickets, with a notable impact on the long-lived strain. This research sheds light on the intriguing potential of RV and NDs as sirtuin activators in house crickets. It might be a milestone for future investigations into sirtuin activity and its potential implications for longevity within the same species, laying the groundwork for broader applications in aging and lifespan extension research. Full article
(This article belongs to the Special Issue Sirtuins as Players in Cell Metabolism and Functions)
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17 pages, 102345 KiB  
Article
Epigenomics Analysis of the Suppression Role of SIRT1 via H3K9 Deacetylation in Preadipocyte Differentiation
by Youzhualamu Yang, Wei Peng, Xiaolong Su, Binglin Yue, Shi Shu, Jikun Wang, Changqi Fu, Jincheng Zhong and Hui Wang
Int. J. Mol. Sci. 2023, 24(14), 11281; https://doi.org/10.3390/ijms241411281 - 10 Jul 2023
Cited by 3 | Viewed by 1140
Abstract
Sirtuin 1 (SIRT1) overexpression significantly inhibits lipid deposition during yak intramuscular preadipocyte (YIMA) differentiation; however, the regulatory mechanism remains unknown. We elucidated the role of SIRT1 in YIMA differentiation using lentivirus-mediated downregulation technology and conducted mRNA-seq and ChIP-seq assays using H3K9ac [...] Read more.
Sirtuin 1 (SIRT1) overexpression significantly inhibits lipid deposition during yak intramuscular preadipocyte (YIMA) differentiation; however, the regulatory mechanism remains unknown. We elucidated the role of SIRT1 in YIMA differentiation using lentivirus-mediated downregulation technology and conducted mRNA-seq and ChIP-seq assays using H3K9ac antibodies after SIRT1 overexpression in order to reveal SIRT1 targets during YIMA adipogenesis. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed in order to identify the functional annotation of common genes. In addition, a potential target of SIRT1 was selected to verify its effects on the differentiation and proliferation of YIMAs. SIRT1 interfered with lipid deposition and promoted YIMA differentiation. In total, 143,518 specific peaks were identified after SIRT1 overexpression, where genes associated with downregulation peaks were enriched in transcription, gene expression, lipid-related processes, and classical lipid-related pathways. The H3K9ac signal in the whole genome promoter region (2 kb upstream and downstream of the transcription start site (TSS)) was weakened, and the peaks were distributed across all gene functional regions. Genes that lost signals in their TSS region or gene body region were enriched in both biological processes and pathways associated with lipogenesis. The ChIP-seq results revealed 714 common differential genes in mRNA-seq, which were enriched in “MAPK signaling”, “lipid and atherosclerosis”, “mTOR signaling”, and “FoxO signaling” pathways. A total of 445 genes were downregulated in both their H3K9ac signals and mRNA expression, and one of their most significantly enriched pathways was FoxO signaling. Nine genes (FBP2, FPGT, HSD17B11, KCNJ15, MAP3K20, SLC5A3, TRIM23, ZCCHC10, and ZMYM1) lost the H3K9ac signal in their TSS regions and had low mRNA expression, and three genes (KCNJ15, TGM3, and TRIM54) had low expression but lost their H3K9ac signal in the gene body region. The interference of TRIM23 significantly inhibited fat deposition during preadipocyte differentiation and promoted cell proliferation by increasing S-phase cell numbers. The present study provides new insights into the molecular mechanism of intramuscular fat content deposition and the epigenetic role of SIRT1 in adipocyte differentiation. Full article
(This article belongs to the Special Issue Sirtuins as Players in Cell Metabolism and Functions)
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