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Special Issue "Sirtuins as Players in Cell Metabolism and Functions"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 1 January 2024 | Viewed by 739

Special Issue Editors

Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, 84081 Baronissi, Italy
Interests: the effects of environmental pollutants on human health; the role of the endocannabinoid system in the processes of carcinogenicity, inflammation, neurogenesis and neuronal differentiation
Special Issues, Collections and Topics in MDPI journals
Department of Movement and Wellness Sciences, Parthenope University of Naples, I-80133 Naples, Italy
Interests: endocannabinoid system; endocannabinoids–GnRH–steroids crosstalk; kisspeptins; reproduction; HPG axis; spermatogenesis; spermatozoa; endocrine disruptors; epigenetics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Sirtuins or silent information regulator 2 (SIR2) proteins are a family of deacetylases discovered in the 1970s in yeast. Since their discovery, sirtuins have been found in organisms ranging from bacteria to plants, and animals. Different forms of sirtuins are present in the cytoplasm, nucleus and mitochondria thus suggesting a key role for these proteins in regulating cell functions and metabolism. Sirtuins are also epigenetic erasers catalyzing post-translational deacetylation of other proteins in response to environmental cues, thus affecting gene silencing, cell survival, proliferation, and differentiation. Although the precise mechanisms of action of these proteins are still unknown, sirtuins’ dysregulation has been related to the pathogenesis of different diseases and new insights are emerging which suggest that sirtuins are involved in redox signaling, immunomodulation, neurodegeneration, aging, cancer, and reproduction. This highlights their potential to be targeted in pharmacological approaches based on sirtuins’ modulators. Therefore, this Special Issue welcomes comprehensive reviews and research papers which aim to provide an up-to-date report on the role of sirtuins in cell metabolism and functions with particular emphasis on molecular mechanisms and epigenetic effects in living organisms as well as their therapeutic potential in experimental model systems and humans.

Dr. Antonietta Santoro
Prof. Dr. Rosaria Meccariello
Guest Editors

Manuscript Submission Information

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  • sirtuins
  • epigenetics effects
  • SIRT modulators
  • neurodegeneration
  • neuroprotection and neuroimmunology
  • control of reproduction
  • cell metabolism
  • ageing
  • immunomodulation

Published Papers (1 paper)

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Epigenomics Analysis of the Suppression Role of SIRT1 via H3K9 Deacetylation in Preadipocyte Differentiation
Int. J. Mol. Sci. 2023, 24(14), 11281; https://doi.org/10.3390/ijms241411281 - 10 Jul 2023
Cited by 1 | Viewed by 486
Sirtuin 1 (SIRT1) overexpression significantly inhibits lipid deposition during yak intramuscular preadipocyte (YIMA) differentiation; however, the regulatory mechanism remains unknown. We elucidated the role of SIRT1 in YIMA differentiation using lentivirus-mediated downregulation technology and conducted mRNA-seq and ChIP-seq assays using H3K9ac [...] Read more.
Sirtuin 1 (SIRT1) overexpression significantly inhibits lipid deposition during yak intramuscular preadipocyte (YIMA) differentiation; however, the regulatory mechanism remains unknown. We elucidated the role of SIRT1 in YIMA differentiation using lentivirus-mediated downregulation technology and conducted mRNA-seq and ChIP-seq assays using H3K9ac antibodies after SIRT1 overexpression in order to reveal SIRT1 targets during YIMA adipogenesis. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed in order to identify the functional annotation of common genes. In addition, a potential target of SIRT1 was selected to verify its effects on the differentiation and proliferation of YIMAs. SIRT1 interfered with lipid deposition and promoted YIMA differentiation. In total, 143,518 specific peaks were identified after SIRT1 overexpression, where genes associated with downregulation peaks were enriched in transcription, gene expression, lipid-related processes, and classical lipid-related pathways. The H3K9ac signal in the whole genome promoter region (2 kb upstream and downstream of the transcription start site (TSS)) was weakened, and the peaks were distributed across all gene functional regions. Genes that lost signals in their TSS region or gene body region were enriched in both biological processes and pathways associated with lipogenesis. The ChIP-seq results revealed 714 common differential genes in mRNA-seq, which were enriched in “MAPK signaling”, “lipid and atherosclerosis”, “mTOR signaling”, and “FoxO signaling” pathways. A total of 445 genes were downregulated in both their H3K9ac signals and mRNA expression, and one of their most significantly enriched pathways was FoxO signaling. Nine genes (FBP2, FPGT, HSD17B11, KCNJ15, MAP3K20, SLC5A3, TRIM23, ZCCHC10, and ZMYM1) lost the H3K9ac signal in their TSS regions and had low mRNA expression, and three genes (KCNJ15, TGM3, and TRIM54) had low expression but lost their H3K9ac signal in the gene body region. The interference of TRIM23 significantly inhibited fat deposition during preadipocyte differentiation and promoted cell proliferation by increasing S-phase cell numbers. The present study provides new insights into the molecular mechanism of intramuscular fat content deposition and the epigenetic role of SIRT1 in adipocyte differentiation. Full article
(This article belongs to the Special Issue Sirtuins as Players in Cell Metabolism and Functions)
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