New Molecular Insights in Mitochondrial Medicine
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (20 April 2024) | Viewed by 862
Special Issue Editor
Interests: cancer; biomarkers; mitochondria; target drugs; clinical chemistry; laboratory medicine
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Pathogenetic role for mitochondrial dysfunction has been invoked in a growing number of illnesses without sufficient experimental support to precisely establish the molecular pathophysiological mechanisms. Indeed, mitochondrial physiology and pathophysiology are very complex, and the role of the organelles in bioenergetics is strictly linked to other essential functions such as anabolic pathways, redox balance, cell death and differentiation, and mitosis, along with more specialized cell functions including calcium homeostasis and thermogenesis, reactive oxygen species (ROS) and reactive nitric oxide species signalling, ion channels, and metabolite transporters. The same complexity and heterogeneity can be surmised from the range of congenital mitochondrial diseases, providing further evidence of the difficulty in correctly approaching mitochondrial pathophysiology. Importantly, this complexity caused a breaking up of mitochondrial research and consequently of specific literature in various and spuriously unrelated topics (mitochondria and calcium, mitochondria and apoptosis, mitochondria and oxidative phosphorylation, mitochondria and ROS, mitochondria and immunity, and so on) which further tangled a correct scientific approach.
At last but not least, mitochondria showed an intriguing pathogenetic roles in pathophysiology of COVID-19.
These unique aspects of mitochondria should stimulate to pay more attention than that usually devoted to both the pathological and clinical aspects related to these organelles. Moreover, their typical structural and functional characteristics may make mitochondria a valuable target for xenobiotics and this pathological interaction could have a significant role not only in potential novel therapeutic approaches but also in neglected iatrogenic diseases.
These intriguing and too often neglected different pathogenetic mechanisms push to better spread the knowledge of these various aspects of mitochondrial pathophysiology, to analyse and integrate such data to better spread their knowledge and so stimulate potential clinical applications in terms of diagnosis and above all of therapy.
Dr. Roberto Scatena
Guest Editor
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