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Dear Colleagues,

The advances in plant systems biology and plant biotechnology over the last decade have revealed numerous aspects of complex phenomena such as plant growth, development, and responses to the environment. Today, with the aid of cutting-edge omics techniques along with sophisticated bioinformatics analysis and mathematical modeling, we are able to obtain unparalleled amounts of data on the state of plant systems and predict how they can react in various circumstances. By exploiting these powerful tools, we now have limitless prospects for not only comprehending the intricate mechanisms of biological processes, but also realizing the full potential of plants as crucial sources of food and valuable metabolites. This interdisciplinary approach offers vast opportunities for both scientific inquiry and practical applications.

We cordially invite you to submit your research to the Special Issue, “Selected Papers from the International Conference on Plant Systems Biology and Biotechnology 2023”, dedicated to ICPSBB 2023. Colleagues who attended ICPSBB 2023 are eligible to apply. Topics covered by ICPSBB 2023 included abiotic and oxidative stress, bioinformatics and computational modeling, plant biotechnology, genetics and genomics, molecular biology, molecular breeding, plant signaling and development, and plant systems biology.

In line with the policy of IJMS, this Special Issue focuses on molecular studies in biology and chemistry, with a strong emphasis on molecular biology, molecular genetics, and plant systems biology.

Prof. Dr. Tsanko S. Gechev
Dr. Veselin Petrov
Guest Editors

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Keywords

abiotic and oxidative stress
bioinformatics and computational modeling
genetics and genomics
molecular breeding
plant biotechnology
molecular biology
plant systems biology

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Research

23 pages, 8137 KiB

Open AccessArticle

Metabolome Profiling of Marrubium peregrinum L. and Marrubium friwaldskyanum Boiss Reveals Their Potential as Sources of Plant-Based Pharmaceuticals

by Donika Gyuzeleva, Maria Benina, Valentina Ivanova, Emil Vatov, Saleh Alseekh, Tsvetelina Mladenova, Rumen Mladenov, Krasimir Todorov, Anelia Bivolarska and Plamen Stoyanov

Int. J. Mol. Sci. 2023, 24(23), 17035; https://doi.org/10.3390/ijms242317035 - 01 Dec 2023

Cited by 1 | Viewed by 730

Abstract

Marrubium species have been used since ancient times as food additives and curative treatments. Their phytochemical composition and various pharmacological activities were the focus of a number of scientific investigations but no comprehensive metabolome profiling to identify the numerous primary and secondary metabolites has been performed so far. This study aimed to generate a comprehensive picture of the total metabolite content of two Marrubium species—M. peregrinum and M. friwaldskyanum—to provide detailed information about the main primary and secondary metabolites. In addition, the elemental composition was also evaluated. For this purpose, non-targeted metabolomic analyses were conducted using GC-MS, UPLC-MS/MS and ICP-MS approaches. Nearly 500 compounds and 12 elements were detected and described. The results showed a strong presence of phenolic acids, flavonoids and their glucosides, which are generally of great interest due to their various pharmacological activities. Furthermore, tissue-specific analyses for M. friwaldskyanum stem, leaves and flowers were carried out in order to outline the sources of potentially important bioactive molecules. The results generated from this study depict the Marrubium metabolome and reveal its dual scientific importance—from one side, providing information about the metabolites that is fundamental and vital for the survival of these species, and from the other side, defining the large diversity of secondary substances that are a potential source of phytotherapeutic agents. Full article

(This article belongs to the Special Issue Selected Papers from the International Conference on Plant Systems Biology)

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