Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
7.8
5.6
Journals
IJMS
Special Issues
Biological Biomarkers of Mild Traumatic Brain Injury
ijms-logo
Submit to Special Issue Submit Abstract to Special Issue Review for IJMS Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Biological Biomarkers of Mild Traumatic Brain Injury

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 20 June 2024 | Viewed by 1245

Special Issue Editors

Prof. Dr. Vincent Sapin

E-Mail Website1 Website2
Guest Editor
Department of Biochemistry and Molecular Genetics, CHU Clermont-Ferrand, 63000 Clermont-Ferrand, France
Interests: receptor of advanced glycation endproducts; retinoids; acute respiratory distress syndrome; premature rupture of membranes; sterile inflammation; diseases biomarkers; traumatic brain injury; S100B protein
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Damien Bouvier

E-Mail Website
Guest Editor
Biochemistry and Molecular Genetic Department, CHU Clermont-Ferrand, Faculty of Medicine, Université Clermont-Auvergne, CNRS 6293, INSERM 1103, GReD, 63000 Clermont-Ferrand, France
Interests: MTBI; S100B; PPROM; biomarkers

Special Issue Information

Dear Colleagues,

Of the three types of TBI (mild, moderate and severe), mild traumatic brain injury (TBI) is the most frequent (80%). Despite its name, mild TBI can result in death and intracranial lesions for 5 to 10% of the affected patients. The diagnosis of such complications was based on clinical examination, the identification of risk factors and imagery (the gold standard is CT scan tomography). Due to its low relative ability to identify intracranial lesions, the use of CT scan is limited, and due to excessive radiation potentially leading to cancer, repeated CT scanning is not recommended. In recent years, alternative diagnosis tools have been identified and the biological markers have been highly tested and developed. This Special Issue welcomes original papers and reviews dealing with the implications of biological biomarkers in the diagnosis and prognosis of the mild traumatic brain injury.

Prof. Dr. Vincent Sapin
Prof. Dr. Damien Bouvier
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mild traumatic brain injury
  • blood biomarker
  • salivary biomarkers
  • micro-RNA
  • concussion
  • diagnosis
  • prognosis

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

11 pages, 899 KiB  
Article
Comparison of GFAP and UCH-L1 Measurements Using Two Automated Immunoassays (i-STAT® and Alinity®) for the Management of Patients with Mild Traumatic Brain Injury: Preliminary Results from a French Single-Center Approach
by Charlotte Oris, Clara Khatib-Chahidi, Bruno Pereira, Valentin Bailly Defrance, Damien Bouvier and Vincent Sapin
Int. J. Mol. Sci. 2024, 25(8), 4539; https://doi.org/10.3390/ijms25084539 - 21 Apr 2024
Viewed by 329
Abstract
The measurement of blood glial fibrillary acidic protein (GFAP) and ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) may assist in the management of mild traumatic brain injury (mTBI). This study aims to compare GFAP and UCH-L1 values measured using a handheld device with those measured [...] Read more.
The measurement of blood glial fibrillary acidic protein (GFAP) and ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) may assist in the management of mild traumatic brain injury (mTBI). This study aims to compare GFAP and UCH-L1 values measured using a handheld device with those measured using a core laboratory platform. We enrolled 230 mTBI patients at intermediate risk of complications. Following French guidelines, a negative S100B value permits the patient to be discharged without a computed tomography scan. Plasma GFAP and UCH-L1 levels were retrospectively measured using i-STAT® and Alinity® i analyzers in patients managed within 12 h post-trauma. Our analysis indicates a strong correlation of biomarker measurements between the two analyzers. Cohen’s kappa coefficients and Lin’s concordance coefficients were both ≥0.7, while Spearman’s correlation coefficient was 0.94 for GFAP and 0.90 for UCH-L1. Additionally, the diagnostic performance in identifying an intracranial lesion was not significantly different between the two analyzers, with a sensitivity of 100% and specificity of approximately 30%. GFAP and UCH-L1 levels measured using Abbott’s i-STAT® and Alinity® i platform assays are highly correlated both analytically and clinically in a cohort of 230 patients managed for mTBI according to French guidelines. Full article
(This article belongs to the Special Issue Biological Biomarkers of Mild Traumatic Brain Injury)
►▼ Show Figures

Figure 1

13 pages, 2404 KiB  
Article
Transcriptomic Signatures of Neuronally Derived Extracellular Vesicles Reveal the Presence of Olfactory Receptors in Clinical Samples from Traumatic Brain Injury Patients
by Manish Bhomia, Yanru Feng, Piper Deleon, Claudia S. Robertson, Firas Kobeissy, Kevin K. Wang and Barbara Knollmann-Ritschel
Int. J. Mol. Sci. 2024, 25(5), 2777; https://doi.org/10.3390/ijms25052777 - 28 Feb 2024
Viewed by 661
Abstract
Traumatic brain injury (TBI) is defined as an injury to the brain by external forces which can lead to cellular damage and the disruption of normal central nervous system functions. The recently approved blood-based biomarkers GFAP and UCH-L1 can only detect injuries which [...] Read more.
Traumatic brain injury (TBI) is defined as an injury to the brain by external forces which can lead to cellular damage and the disruption of normal central nervous system functions. The recently approved blood-based biomarkers GFAP and UCH-L1 can only detect injuries which are detectable on CT, and are not sensitive enough to diagnose milder injuries or concussion. Exosomes are small microvesicles which are released from the cell as a part of extracellular communication in normal as well as diseased states. The objective of this study was to identify the messenger RNA content of the exosomes released by injured neurons to identify new potential blood-based biomarkers for TBI. Human severe traumatic brain injury samples were used for this study. RNA was isolated from neuronal exosomes and total transcriptomic sequencing was performed. RNA sequencing data from neuronal exosomes isolated from serum showed mRNA transcripts of several neuronal genes. In particular, mRNAs of several olfactory receptor genes were present at elevated concentrations in the neuronal exosomes. Some of these genes were OR10A6, OR14A2, OR6F1, OR1B1, and OR1L1. RNA sequencing data from exosomes isolated from CSF showed a similar elevation of these olfactory receptors. We further validated the expression of these samples in serum samples of mild TBI patients, and a similar up-regulation of these olfactory receptors was observed. The data from these experiments suggest that damage to the neurons in the olfactory neuroepithelium as well as in the brain following a TBI may cause the release of mRNA from these receptors in the exosomes. Hence, olfactory receptors can be further explored as biomarkers for the diagnosis of TBI. Full article
(This article belongs to the Special Issue Biological Biomarkers of Mild Traumatic Brain Injury)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop