The Bidirectional Role of Sleep in Glia-Immune Signalling
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: closed (15 April 2024) | Viewed by 1955
Special Issue Editor
Special Issue Information
Dear Colleagues,
Not getting the proper amount or quality of sleep leads to more than just feeling tired. In fact, disturbing sleep homeostasis leads to neurological disorders such as sleep apnea, narcolepsy, and fatal familial insomnia, and is additionally associated with neurodegenerative dementia, neuromuscular disorders, and stroke. Besides sleep, a unifying element across these neurological disorders is glia–immune signalling. While the vast majority of studies on sleep have traditionally focused on neurons, glia–immune signalling has increasingly garnered attention for its important role in sleep physiology as well as sleep-driven changes in both the central and peripheral nervous systems. Furthermore, glia cells influence neuronal activity, which may additionally influence neuronal circuits that control sleep and wake behavior. Similarly, disturbance of the sleep/wake circuitry may alter glial–immune function, which promotes chronic neuroinflammation. There is still much to unravel about the mechanisms that link glia–immune signalling to sleep, including but not limited to their role in metabolism, synaptic plasticity, and the restoration of physiological homeostasis through healthy aging.
For this Special Issue of IJMS, we welcome the submission of review and research articles that aim to identify and discuss potential mechanisms through which sleep and glia–immune signalling influence each other in regulating physiological functions.
Dr. Samira Parhizkar
Guest Editor
Manuscript Submission Information
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Keywords
- sleep
- glia
- innate immune system
- adaptive immune system
- inflammation
- sleep disorders
