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Cellular and Molecular Biology of Cilia: Structure, Function, and Beyond
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Cellular and Molecular Biology of Cilia: Structure, Function, and Beyond

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 31 October 2024 | Viewed by 907

Special Issue Editor

Prof. Dr. Takashi Nakahari

E-Mail Website
Guest Editor
Research Unit for Epithelial Physiology, Research Organization of Science and Technology, BKC Ritsumeikan University, Kusatsu 525-8755, Shiga, Japan
Interests: motile cilia; airway biology; epithelial ion transport; cell signaling; intracellular Cl-signaling; cell volume regulation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cilia are hair-like projections with axoneme. The non-motile primary cilia regulate cellular signals in development and homeostasis. The motile cilia, which are driven by dyneins in the axoneme, regulate the movements of unicellular organisms and the transport in the epithelial surface. Eukaryotic cells possess one or two cilia, such as “Chlamydomonas”, or many cilia, such as “Paramecium”. In vertebrates, multiciliated cells cover the epithelial surfaces of specialized organs. Their cilia beat in a coordinated and polarized manner to produce unidirectional fluid flow, which plays critical roles in Left-Right determination in embryo, circulation of cerebrospinal fluid in the brain, mucociliary clearance in airways, and egg transport in oviducts. Dysfunction of cilia causes a variety of diseases, called “ciliopathy”. Recent research in the cellular and molecular biology of cilia increases our knowledge. In this issue, we provide the topics in the recent cilia research.

Prof. Dr. Takashi Nakahari
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • cilia
  • ciliopathy
  • airway biology
  • infertility
  • brain ventricle

Published Papers (1 paper)

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Research

19 pages, 9247 KiB  
Article
Ambroxol-Enhanced Frequency and Amplitude of Beating Cilia Controlled by a Voltage-Gated Ca2+ Channel, Cav1.2, via pHi Increase and [Cl−]i Decrease in the Lung Airway Epithelial Cells of Mice
by Takashi Nakahari, Chihiro Suzuki, Kotoku Kawaguchi, Shigekuni Hosogi, Saori Tanaka, Shinji Asano, Toshio Inui and Yoshinori Marunaka
Int. J. Mol. Sci. 2023, 24(23), 16976; https://doi.org/10.3390/ijms242316976 - 30 Nov 2023
Viewed by 701
Abstract
Ambroxol (ABX), a frequently prescribed secretolytic agent which enhances the ciliary beat frequency (CBF) and ciliary bend angle (CBA, an index of amplitude) by 30%, activates a voltage-dependent Ca2+ channel (CaV1.2) and a small transient Ca2+ release in the [...] Read more.
Ambroxol (ABX), a frequently prescribed secretolytic agent which enhances the ciliary beat frequency (CBF) and ciliary bend angle (CBA, an index of amplitude) by 30%, activates a voltage-dependent Ca2+ channel (CaV1.2) and a small transient Ca2+ release in the ciliated lung airway epithelial cells (c-LAECs) of mice. The activation of CaV1.2 alone enhanced the CBF and CBA by 20%, mediated by a pHi increasei and a [Cl−]i decrease in the c-LAECs. The increase in pHi, which was induced by the activation of the Na+-HCO3− cotransporter (NBC), enhanced the CBF (by 30%) and CBA (by 15–20%), and a decrease in [Cl−]i, which was induced by the Cl− release via anoctamine 1 (ANO1), enhanced the CBA (by 10–15%). While a Ca2+-free solution or nifedipine (an inhibitor of CaV1.2) inhibited 70% of the CBF and CBA enhancement using ABX, CaV1.2 enhanced most of the CBF and CBA increases using ABX. The activation of the CaV1.2 existing in the cilia stimulates the NBC to increase pHi and ANO1 to decrease the [Cl−]i in the c-LAECs. In conclusion, the pHi increase and the [Cl−]i decrease enhanced the CBF and CBA in the ABX-stimulated c-LAECs. Full article
(This article belongs to the Special Issue Cellular and Molecular Biology of Cilia: Structure, Function, and Beyond)
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