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Gonadotropin Cell Transduction Mechanisms 2.0
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Gonadotropin Cell Transduction Mechanisms 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 3131

Special Issue Editors

Prof. Dr. Annunziata Mauro

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Guest Editor
Faculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo, Italy
Interests: cell biology; biology of stem cells; biology of reproduction; ovarian angiogenesis; signal transduction; molecular biology; tissue regeneration; regenerative medicine; cancer; histology
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Barbara Barboni

E-Mail Website
Guest Editor
Department of Biosciences and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo, Italy
Interests: cell biology; biology of amniotic derived stem cells; tissue regeneration; regenerative medicine; biology of reproduction; ovarian angiogenesis; signal transduction; molecular biology; advanced reproductive biotechnology techniques
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Paolo Berardinelli

E-Mail Website
Guest Editor
Faculty of Biosciences and Agro-Food and Environmental Technologies, University of Teramo, 64100 Teramo, Italy
Interests: cell biology; biology of amniotic derived stem cells; biology of reproduction; ovarian angiogenesis; signal transduction; histology; tissue regeneration; regenerative medicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Gonadotropins act in concert in the regulation of the female and male reproductive systems. Through intricate endocrine communication routes, paracrine and autocrine communication along the HPG axis, they sustain the production of sex steroids by gonads. Different signaling cascades and transcriptional mechanisms are activated, depending on the variation in GnRH pulse frequency, after the synthesis and release of FSH and LH, whose biological effects are mediated directly by coupled receptors (FSHR and LHCGR) or indirectly through different mediators. The orchestrated signaling activation promotes different biological responses, such as ovarian angiogenesis, folliculogenesis, oocyte selection, fertilization and pregnancy, as well as testicular development and spermatogenesis. Moreover, gonadotropins are intertwined in a network of interactions with other hormones, which all contribute to the functioning of the reproductive system. The dysregulation of one or more of the transduction mechanisms evolves in reproductive disorders, such as infertility and cancer. Despite recent progress in understanding the mechanisms and signaling mediated by gonadotropins, their complex pathways in cells remain to be fully elucidated. The increasing new techniques applied in all fields of biotechnology and the in vitro and in vivo study of reproductive cells, as well as new sources of stem cells, could help to clarify most of the unknown signaling mediated by gonadotropins, opening up new perspectives in the comprehension of physiological and pathological events in the biology of reproduction.

Contributions to this Special Issue, of both original research articles and topical reviews, will provide new insights into the mechanisms of action of gonadotropins, deepen our understanding of their biological roles in health and disease, and reveal novel therapeutic opportunities in reproductive and regenerative medicine.

Due to the success of the 1st edition, we would like to add more results and new insights from recent research projects.

https://www.mdpi.com/journal/ijms/special_issues/Gonadotropin_cell

Prof. Dr. Annunziata Mauro
Prof. Dr. Barbara Barboni
Prof. Dr. Paolo Berardinelli
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gonadotropins
  • GnRH
  • signal transduction
  • reproduction
  • fertility
  • testis
  • ovary
  • spermatogenesis
  • ovogenesis
  • gametes
  • stem cells
  • sex steroids

Related Special Issue

Published Papers (2 papers)

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Research

12 pages, 1152 KiB  
Article
Repeated Rounds of Gonadotropin Stimulation Induce Imbalance in the Antioxidant Machinery and Activation of Pro-Survival Proteins in Mouse Oviducts
by Valentina Di Nisio, Sevastiani Antonouli, Sabrina Colafarina, Osvaldo Zarivi, Gianna Rossi, Sandra Cecconi and Anna Maria Giuseppina Poma
Int. J. Mol. Sci. 2023, 24(11), 9294; https://doi.org/10.3390/ijms24119294 - 26 May 2023
Viewed by 1159
Abstract
Controlled ovarian stimulation (COS) through gonadotropin administration has become a common procedure in assisted reproductive technologies. COS’s drawback is the formation of an unbalanced hormonal and molecular environment that could alter several cellular mechanisms. On this basis, we detected the presence of mitochondrial [...] Read more.
Controlled ovarian stimulation (COS) through gonadotropin administration has become a common procedure in assisted reproductive technologies. COS’s drawback is the formation of an unbalanced hormonal and molecular environment that could alter several cellular mechanisms. On this basis, we detected the presence of mitochondrial DNA (mtDNA) fragmentation, antioxidant enzymes (catalase; superoxide dismutases 1 and 2, SOD-1 and -2; glutathione peroxidase 1, GPx1) and apoptotic (Bcl-2-associated X protein, Bax; cleaved caspases 3 and 7; phosphorylated (p)-heat shock protein 27, p-HSP27) and cell-cycle-related proteins (p-p38 mitogen-activated protein kinase, p-p38 MAPK; p-MAPK activated protein kinase 2, p-MAPKAPK2; p-stress-activated protein kinase/Jun amino-terminal kinase, p-SAPK/JNK; p-c-Jun) in the oviducts of unstimulated (Ctr) and repeatedly hyperstimulated (eight rounds, 8R) mice. While all the antioxidant enzymes were overexpressed after 8R of stimulation, mtDNA fragmentation decreased in the 8R group, denoting a present yet controlled imbalance in the antioxidant machinery. Apoptotic proteins were not overexpressed, except for a sharp increase in the inflammatory-related cleaved caspase 7, accompanied by a significant decrease in p-HSP27 content. On the other hand, the number of proteins involved in pro-survival mechanisms, such as p-p38 MAPK, p-SAPK/JNK and p-c-Jun, increased almost 50% in the 8R group. Altogether, the present results demonstrate that repeated stimulations cause the activation of the antioxidant machinery in mouse oviducts; however, this is not sufficient to induce apoptosis, and is efficiently counterbalanced by activation of pro-survival proteins. Full article
(This article belongs to the Special Issue Gonadotropin Cell Transduction Mechanisms 2.0)
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24 pages, 4024 KiB  
Article
IVM Advances for Early Antral Follicle-Enclosed Oocytes Coupling Reproductive Tissue Engineering to Inductive Influences of Human Chorionic Gonadotropin and Ovarian Surface Epithelium Coculture
by Alessia Peserico, Chiara Di Berardino, Giulia Capacchietti, Chiara Camerano Spelta Rapini, Liliana Liverani, Aldo Roberto Boccaccini, Valentina Russo, Annunziata Mauro and Barbara Barboni
Int. J. Mol. Sci. 2023, 24(7), 6626; https://doi.org/10.3390/ijms24076626 - 01 Apr 2023
Cited by 2 | Viewed by 1550
Abstract
In vitro maturation (IVM) is not a routine assisted reproductive technology (ART) for oocytes collected from early antral (EA) follicles, a large source of potentially available gametes. Despite substantial improvements in IVM in the past decade, the outcomes remain low for EA-derived oocytes [...] Read more.
In vitro maturation (IVM) is not a routine assisted reproductive technology (ART) for oocytes collected from early antral (EA) follicles, a large source of potentially available gametes. Despite substantial improvements in IVM in the past decade, the outcomes remain low for EA-derived oocytes due to their reduced developmental competences. To optimize IVM for ovine EA-derived oocytes, a three-dimensional (3D) scaffold-mediated follicle-enclosed oocytes (FEO) system was compared with a validated cumulus-oocyte complex (COC) protocol. Gonadotropin stimulation (eCG and/or hCG) and/or somatic cell coculture (ovarian vs. extraovarian-cell source) were supplied to both systems. The maturation rate and parthenogenetic activation were significantly improved by combining hCG stimulation with ovarian surface epithelium (OSE) cells coculture exclusively on the FEO system. Based on the data, the paracrine factors released specifically from OSE enhanced the hCG-triggering of oocyte maturation mechanisms by acting through the mural compartment (positive effect on FEO and not on COC) by stimulating the EGFR signaling. Overall, the FEO system performed on a developed reproductive scaffold proved feasible and reliable in promoting a synergic cytoplasmatic and nuclear maturation, offering a novel cultural strategy to widen the availability of mature gametes for ART. Full article
(This article belongs to the Special Issue Gonadotropin Cell Transduction Mechanisms 2.0)
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