Pathways Regulating Macrophage Phagocytosis of Tumor Cells
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (15 December 2023) | Viewed by 4639
Special Issue Editor
Interests: cancer; glioblastoma; invasion; macrophages; microenvironment; microglia; chemokines; metastasis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cancer immunotherapy has yielded exciting results in the clinic. Thus far the majority of approaches has been focused on stimulating the cytotoxic T lymphocyte (CTL) response to cancer cells by either targeting immune checkpoints (PD-L1 and CTLA4) or by genetic manipulation of the patient’s T cells with chimeric antigen receptors (CAR-T). However, recruiting macrophages in the fight against cancer has been gaining more attention recently. In particular, antibody-mediated blockade of the CD47 “don’t eat me” receptor to stimulate phagocytosis of tumor cells has been experimentally validated in animal models and is currently undergoing clinical trials. In addition, genetic engineering and modification of patient monocyte/macrophages ex-vivo using CAR-M therapy is an emerging approach which holds great promise as an effective strategy for attacking solid tumors. The regulation and mechanism of macrophage phagocytosis of cancer cells however is complex and likely involves many cell-surface receptors and signaling pathways. This special edition focuses on the juxtacrine interactions between tumor associated macrophages and cancer cells which can promote phagocytosis and potentially be harnessed for therapeutic application.
Dr. Salvatore Coniglio
Guest Editor
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