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Molecular and Morphological Research on the Toxicity of Pollutants 2.0
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Molecular and Morphological Research on the Toxicity of Pollutants 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".

Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 1887

Special Issue Editor

Prof. Dr. Elvira Brunelli

E-Mail Website
Guest Editor
Department of Biology, Ecology and Earth Science, University of Calabria, 87036 Rende, Italy
Interests: diseases in animals especially in vertebrates; organic and inorganic pollutants; reproduction and development; innovative methods for eco-toxicology; in vivo models; use and development of molecular and morpho-functional approaches in toxicological studies; respiratory organs, their diseases and early stage of development and alterations
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The widespread use of chemicals for industrial, domestic, and agricultural purposes leads to a large discharge into different environmental compartments. Nowadays, pollution is an issue of great concern.

Morpho-functional analysis and molecular biochemical approaches are commonly used to study the toxic effects and mechanisms of environmental pollutants, and they provide a valuable tool for quickly assessing the health of organisms.  Linking the organismal dysfunction with the presence of pollutants should be based on sound scientific evidence.

The special issue focuses on molecular and morphological research on the toxicity of pollutants. We seek manuscripts (e.g., reviews, original research articles) that found evidence of a link between the morphological and functional response of the organism to environmental disturbance.

Prof. Dr. Elvira Brunelli
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pollutants
  • toxicity
  • organismal dysfunction
  • functional response
  • toxicity effect
  • toxicity mechanism

Published Papers (1 paper)

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Research

18 pages, 11936 KiB  
Article
First In Vivo Insights on the Effects of Tempol-Methoxycinnamate, a New UV Filter, as Alternative to Octyl Methoxycinnamate, on Zebrafish Early Development
by Elisabetta Damiani, Fiorenza Sella, Paola Astolfi, Roberta Galeazzi, Oliana Carnevali and Francesca Maradonna
Int. J. Mol. Sci. 2023, 24(7), 6767; https://doi.org/10.3390/ijms24076767 - 05 Apr 2023
Cited by 2 | Viewed by 1565
Abstract
The demand for organic UV filters as active components in sunscreen products has rapidly risen over the last century, as people have gradually realized the hazards of overexposure to UV radiation. Their extensive usage has resulted in their ubiquitous presence in different aquatic [...] Read more.
The demand for organic UV filters as active components in sunscreen products has rapidly risen over the last century, as people have gradually realized the hazards of overexposure to UV radiation. Their extensive usage has resulted in their ubiquitous presence in different aquatic matrices, representing a potential threat to living organisms. In this context, the need to replace classic UV filters such as octyl methoxycinnamate (OMC), one of the most popular UV filters reported to be a potential pollutant of aquatic ecosystems, with more environmentally friendly ones has emerged. In this study, using zebrafish, the first in vivo results regarding the effect of exposure to tempol-methoxycinnamate (TMC), a derivative of OMC, are reported. A comparative study between TMC and OMC was performed, analyzing embryos exposed to similar TMC and OMC concentrations, focusing on morphological and molecular changes. While both compounds seemed not to affect hatching and embryogenesis, OMC exposure caused an increase in endoplasmic reticulum (ER) stress response genes, according to increased eif2ak3, ddit3, nrf2, and nkap mRNA levels and in oxidative stress genes, as observed from modulation of the sod1, sod2, gpr, and trx mRNA levels. On the contrary, exposure to TMC led to reduced toxicity, probably due to the presence of the nitroxide group in the compound’s molecular structure responsible for antioxidant activity. In addition, both UV filters were docked with estrogen and androgen receptors where they acted differently, in agreement with the molecular analysis that showed a hormone-like activity for OMC but not for TMC. Overall, the results indicate the suitability of TMC as an alternative, environmentally safer UV filter. Full article
(This article belongs to the Special Issue Molecular and Morphological Research on the Toxicity of Pollutants 2.0)
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