Regulation of Ubiquitin Family Signaling in Disease 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 20 May 2024 | Viewed by 1054
Special Issue Editor
Interests: HERC; HECT; ubiquitin; MAPK; RAF; p53; NEURL4; ubiquitylation and cell signaling
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
We are organizing a Special Issue of the International Journal of Molecular Sciences (IJMS) (Impact Factor: 5.923 (2020 JCR), Q1 in "Biochemistry & Molecular Biology") focused on the “Regulation of Ubiquitin Family Signaling in Disease 2.0”.
Proteins are regulated by the conjugation of ubiquitin or ubiquitin-like proteins. While a synchronized cascade of three enzyme classes (E1, E2, and E3) is responsible for conjugation, deubiquitinating enzymes (DUBs) are the proteases that remove ubiquitin or ubiquitin-like molecules. This post-translational modification marks proteins by regulating their cellular functions, including their degradation, through the proteasome or the autophagy/lysosome pathway. Thus, ubiquitination/ubiquitin-like modifications have been involved in the regulation of important cellular processes such as cell proliferation, cell differentiation, DNA damage repair, cell cycle, apoptosis, signal transduction, and vesicle traffic, among others. Dysregulation of the conjugation process has been associated with multiple diseases such as neurodegeneration, cancer, viral infections, and inflammation. Understanding the molecular mechanisms involved in all these processes and their regulation is crucial to identify potential targets for the therapeutic treatment of associated diseases.
As volume 1 of the Special Issue “Regulation of Ubiquitin Family Signaling in Disease” has been successful, we will continue to explore updates of the knowledge in the field of ubiquitin family regulation and its association with diseases. As leading researchers in this field, we would like your participation.
We would like to invite you to submit an original research article or a review paper for this Special Issue.
We appreciate your consideration and sincerely hope you will accept our invitation.
Thank you very much.
Prof. Dr. Jose Luis Rosa
Guest Editor
Manuscript Submission Information
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Keywords
- ubiquitin
- SUMO
- NEDD8
- ISG15
- FAT10
- ubiquitin-like proteins
- autophagy
- proteasome
