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Oxidative Stress: Cell Biology and Signal Transduction

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 15 May 2024 | Viewed by 802

Special Issue Editors


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Guest Editor
Department of Anatomy, Cell Biology and Zoology, Science Faculty, University of Extremadura, 06006 Badajoz, Spain
Interests: oxidative stress; apoptosis; biophysics; calcium signalling; cell biology; developmental biology

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Guest Editor
Grupo de Investigación Neuroinmunofisiología y Crononutrición, Departamento de Fisiología, Facultad de Ciencias, Universidad de Extremadura, Avenida de Elvas s/n, 06006 Badajoz, Spain
Interests: cancer biology; antioxidants; reactive oxygen species; molecular biology; mitochondria; cancer therapy
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Special Issue Information

Dear Colleagues,

Oxidative stress is a process of high interest for researchers around the world. Diverse signal recognition receptors and signal transduction pathways have been defined that regulate mitochondrial functions, apoptosis, and development. A perturbation of the equilibrium between reactive oxygen species (ROS) and antioxidant molecules in the cell leads to signalling pathways that cause pathophysiological processes and diseases. Therefore, the understanding of the diverse signalling molecules, signal recognition mechanisms, and signal transduction pathways is fundamental for gaining insight into physiological and pathophysiological processes. This open access Special Issue will combine original research and review articles on oxidative stress. It highlights discoveries, approaches, and technical developments in oxidative stress research with a special interest in molecular data. The main feature of this Special Issue is to advance our understanding of oxidative stress processes in several diseases, which may lead to the discovery of novel molecular diagnostic technologies and targeted therapeutics.

Therefore, authors are invited to submit original research and review articles that address the progress and current standing of cellular signalling processes.

Topics of this Special Issue include, but are not limited to:

  • Key biological processes such as cell cycle, DNA repair, apoptosis, autophagy, angiogenesis, invasion and metastasis.
  • Mitochondrial mechanisms.
  • Degenerative diseases.
  • Cancer epidemiology and prevention.
  • Oxidative agents and their molecular effects.
  • Antioxidant therapy: target discovery, drug design, nutrition, targeted therapy, nanomaterials, personalized medicine.

Dr. David González-Flores
Dr. Javier Espino
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

 

Keywords

  • signalling molecules
  • reactive oxygen species
  • apoptosis
  • signal transduction
  • signalling network
  • second messenger
  • antioxidant molecules
  • oxidant agents

Published Papers (1 paper)

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Review

21 pages, 838 KiB  
Review
Oxidative Effects in Early Stages of Embryo Development Due to Alcohol Consumption
by David González-Flores, Antonia Márquez and Ilda Casimiro
Int. J. Mol. Sci. 2024, 25(7), 4100; https://doi.org/10.3390/ijms25074100 - 07 Apr 2024
Viewed by 650
Abstract
Alcohol, a widely consumed drug, exerts significant toxic effects on the human organism. This review focuses on its impact during fetal development, when it leads to a spectrum of disorders collectively termed Fetal Alcohol Spectrum Disorders (FASD). Children afflicted by FASD exhibit distinct [...] Read more.
Alcohol, a widely consumed drug, exerts significant toxic effects on the human organism. This review focuses on its impact during fetal development, when it leads to a spectrum of disorders collectively termed Fetal Alcohol Spectrum Disorders (FASD). Children afflicted by FASD exhibit distinct clinical manifestations, including facial dysmorphism, delayed growth, and neurological and behavioral disorders. These behavioral issues encompass diminished intellectual capacity, memory impairment, and heightened impulsiveness. While the precise mechanisms underlying alcohol-induced fetal damage remain incompletely understood, research indicates a pivotal role for reactive oxygen species (ROS) that are released during alcohol metabolism, inciting inflammation at the cerebral level. Ethanol metabolism amplifies the generation of oxidant molecules, inducing through alterations in enzymatic and non-enzymatic systems responsible for cellular homeostasis. Alcohol consumption disrupts endogenous enzyme activity and fosters lipid peroxidation in consumers, potentially affecting the developing fetus. Addressing this concern, administration of metformin during the prenatal period, corresponding to the third trimester of human pregnancy, emerges as a potential therapeutic intervention for mitigating FASD. This proposed approach holds promise for ameliorating the adverse effects of alcohol exposure on fetal development and warrants further investigation. Full article
(This article belongs to the Special Issue Oxidative Stress: Cell Biology and Signal Transduction)
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