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The Plasticity of the Innervation of the Urogenital System

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 30 April 2024 | Viewed by 971

Special Issue Editor


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Guest Editor
Department of Animal Anatomy, University of Warmia and Mazury, Olsztyn, Poland
Interests: neuron; veterinary medicine; neuroscience; immunohistochemistry; immunofluorescence Inflammation; immunocytochemistry; immunohistochemical staining; antibodies; neurology

Special Issue Information

Dear Colleagues,

The urogenital system is innervated by a complex network of nerves that regulate a variety of functions, including bladder control, sexual function, and reproductive processes. These nerves are influenced by a variety of factors, including hormonal changes, mechanical stress, inflammation, and neurotrophic factors. This innervation is critical for the proper functioning of the system, and disruptions or damage to the nerves can lead to a range of urogenital disorders and conditions.

The plasticity of the innervation of the urogenital tract refers to the ability of the nerves in the urogenital system to adapt and change in response to various stimuli and conditions. This plasticity helps to maintain the proper function of the urogenital system in the face of changing physiological and environmental demands, by allowing the nerves to respond to changes in hormone levels, tissue damage, inflammation, and other stimuli that can affect urogenital function. For example, in response to injury or inflammation, the nerves may release different neurotransmitters or alter their firing patterns to compensate for the damage and maintain proper function. This plasticity is important for normal physiological functioning, as well as for the development of certain pathologies.

Research in this field is ongoing, and there is still much to be learned about the mechanisms underlying the plasticity of the innervation of the urogenital tract. However, understanding this plasticity may provide new insights into the pathophysiology of urogenital disorders and may lead to the development of new therapies for these conditions.

Prof. Dr. Zenon Pidsudko
Guest Editor

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Keywords

  • neuronal plasticity
  • urogenital tract
  • innervation
  • nerve growth factors
  • neuropeptides
  • neurotrophins
  • nerve injury
  • nerve regeneration
  • pelvic nerves
  • autonomic nervous system
  • smooth muscle dysfunction
  • bladder hyperactivity
  • erectile dysfunction
  • vaginal atrophy
  • neuromodulation

Published Papers (1 paper)

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Research

13 pages, 6872 KiB  
Article
Bisphenol A Effects on Neurons’ Neurochemical Character in the Urinary Bladder Intramural Ganglia of Domestic Pigs
by Krystyna Makowska, Piotr Lech and Sławomir Gonkowski
Int. J. Mol. Sci. 2023, 24(23), 16792; https://doi.org/10.3390/ijms242316792 - 27 Nov 2023
Viewed by 660
Abstract
Bisphenol A (BPA), a substance globally used to produce plastics, is part of many everyday items, including bottles, food containers, electronic elements, and others. It may penetrate the environment and living organisms, negatively affecting, among others, the nervous, immune, endocrine, and cardiovascular systems. [...] Read more.
Bisphenol A (BPA), a substance globally used to produce plastics, is part of many everyday items, including bottles, food containers, electronic elements, and others. It may penetrate the environment and living organisms, negatively affecting, among others, the nervous, immune, endocrine, and cardiovascular systems. Knowledge of the impact of BPA on the urinary bladder is extremely scarce. This study investigated the influence of two doses of BPA (0.05 mg/kg body weight (b.w.)/day and 0.5 mg/kg b.w./day) given orally for 28 days on the neurons situated in the ganglia located in the urinary bladder trigone using the typical double immunofluorescence method. In the study, an increase in the percentage of neurons containing substance P (SP), galanin (GAL), a neuronal isoform of nitric oxide synthase (nNOS—used as the marker of nitrergic neurons), and/or cocaine- and amphetamine-regulated transcript (CART) peptide was noted after BPA administration. The severity of these changes depended on the dose of BPA and the type of neuronal factors studied. The most visible changes were noted in the cases of SP- and/or GAL-positive neurons after administering a higher dose of BPA. The results have shown that oral exposure to BPA, lasting even for a short time, affects the intramural neurons in the urinary bladder wall, and changes in the neurochemical characterisation of these neurons may be the first signs of BPA-induced pathological processes in this organ. Full article
(This article belongs to the Special Issue The Plasticity of the Innervation of the Urogenital System)
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