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Roles of Inflammasomes in Inflammatory Responses and Human Diseases
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Roles of Inflammasomes in Inflammatory Responses and Human Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 25 May 2024 | Viewed by 1232

Special Issue Editor

Dr. Young-Su Yi

E-Mail Website
Guest Editor
Department of Life Sciences, Kyonggi University, Suwon 16227, Republic of Korea
Interests: inflammation; inflammatory/autoimmune diseases; non-canonical inflammasomes; macrophage; anti-inflammatory therapeutics, signaling transduction; immunology; molecular biology; biochemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Inflammation is an innate immune defense that protects our body tissues from pathogens and cellular dangers; however, repeated and prolonged inflammation known as chronic inflammation has been considered as a key risk factor for a variety of human diseases, including inflammatory, autoimmune, infectious diseases, and even cancers. An inflammatory response is initiated when the pathogen recognition receptors (PRRs) of the inflammatory cells recognize the pathogen-associated molecular patterns (PAMPs) or danger-associated molecular patterns (DAMPs), which results in the activation of multiple inflammatory signaling pathways. An inflammatory response consists of two successive steps, priming and triggering. Priming is the step to prepare inflammatory responses by upregulating inflammatory genes, while triggering is the step to activate and boost inflammatory responses by activating inflammasomes and intracellular multiprotein complexes responsible for the stimulation of inflammatory responses. Therefore, inflammasome activation has been regarded as a key determinant for the induction of inflammatory responses and the progression of various human diseases, and the inhibition of inflammatory responses by selective targeting of inflammasomes has been suggested as a promising strategy to develop novel therapeutics for the treatment of these human diseases. However, the roles of inflammasomes and their dysregulation during inflammatory responses and human diseases are still largely unknown and remain to be investigated.

This Special Issue welcomes studies exploring but not limited to the “Roles of Inflammasomes in Inflammatory Responses and Human Diseases”, identifying and validating novel targets regulating inflammasome functions, evaluating anti-inflammatory effects by targeting inflammasomes, and developing potential inflammasome-targeted therapeutics.

Dr. Young-Su Yi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • inflammasome
  • inflammatory responses
  • human diseases
  • anti-inflammatory therapeutics

Published Papers (1 paper)

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Review

17 pages, 1959 KiB  
Review
Roles of the Caspase-11 Non-Canonical Inflammasome in Rheumatic Diseases
by Young-Su Yi
Int. J. Mol. Sci. 2024, 25(4), 2091; https://doi.org/10.3390/ijms25042091 - 08 Feb 2024
Viewed by 908
Abstract
Inflammasomes are intracellular multiprotein complexes that activate inflammatory signaling pathways. Inflammasomes comprise two major classes: canonical inflammasomes, which were discovered first and are activated in response to a variety of pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs), and non-canonical inflammasomes, which [...] Read more.
Inflammasomes are intracellular multiprotein complexes that activate inflammatory signaling pathways. Inflammasomes comprise two major classes: canonical inflammasomes, which were discovered first and are activated in response to a variety of pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs), and non-canonical inflammasomes, which were discovered recently and are only activated in response to intracellular lipopolysaccharide (LPS). Although a larger number of studies have successfully demonstrated that canonical inflammasomes, particularly the NLRP3 inflammasome, play roles in various rheumatic diseases, including rheumatoid arthritis (RA), infectious arthritis (IR), gouty arthritis (GA), osteoarthritis (OA), systemic lupus erythematosus (SLE), psoriatic arthritis (PA), ankylosing spondylitis (AS), and Sjögren’s syndrome (SjS), the regulatory roles of non-canonical inflammasomes, such as mouse caspase-11 and human caspase-4 non-canonical inflammasomes, in these diseases are still largely unknown. Interestingly, an increasing number of studies have reported possible roles for non-canonical inflammasomes in the pathogenesis of various mouse models of rheumatic disease. This review comprehensively summarizes and discusses recent emerging studies demonstrating the regulatory roles of non-canonical inflammasomes, particularly focusing on the caspase-11 non-canonical inflammasome, in the pathogenesis and progression of various types of rheumatic diseases and provides new insights into strategies for developing potential therapeutics to prevent and treat rheumatic diseases as well as associated diseases by targeting non-canonical inflammasomes. Full article
(This article belongs to the Special Issue Roles of Inflammasomes in Inflammatory Responses and Human Diseases)
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