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Recent Advances in Molecular Materials and Biomedicine

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: 10 June 2024 | Viewed by 1124

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Guest Editor
School of Materials Science and Physics, China University of Mining and Technology, Xuzhou, China
Interests: development and application of new materials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue highlights the growing interest in recent advances in molecular materials and biomedicine. Biomedicine is an important engineering field related to improving the level of medical diagnosis and human health, and is the base of academic research and innovation of biomedical information, gene chip, nanotechnology, new materials, and other technologies. With the development of materials science and molecular technology, various molecular materials have received more and more attention in biomedical fields such as biosensing, medical imaging, tissue engineering, regenerative medicine, and targeted drug delivery, including quantum dots, carbon nanotubes, protein nanostructures, gold nanoshells, various inorganic/organic materials, liposomes, and molecular structure composite materials. Although molecular materials have made great progress in the field of biomedicine, further in-depth and comprehensive exploration is still needed, such as natural biological materials (such as cells, viruses, exosomes, protein molecules and other organisms; or shells, coral, bones, insect wings and other natural mineralized materials), a variety of synthetic molecular materials and so on. We welcome the submission of original article, review, and communication.

This Special issue is supervised by Dr. Shijing Wang, who is assisted by our Topical Advisory Panel Member <wsjwendy2023@163.com> (Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, China).

Dr. Jiangmin Jiang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomaterials
  • biomaterials
  • structural/functional/sensor materials
  • self-assembly/macromolecular materials
  • optoelectronic/magnetic materials
  • soft materials
  • molecular diagnostic techniques/methods
  • potential molecular targets
  • functional biological macromolecules
  • biotechnology macromolecules

Published Papers (2 papers)

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Research

14 pages, 2096 KiB  
Article
Profiling of Early Immune Responses to Vaccination Using THP-1-Derived Dendritic Cells
by Lei Ye, Ping Li, Mingzhe Wang, Feng Wu, Sanyang Han and Lan Ma
Int. J. Mol. Sci. 2024, 25(10), 5509; https://doi.org/10.3390/ijms25105509 - 18 May 2024
Viewed by 343
Abstract
The COVID-19 pandemic has made assessing vaccine efficacy more challenging. Besides neutralizing antibody assays, systems vaccinology studies use omics technology to reveal immune response mechanisms and identify gene signatures in human peripheral blood mononuclear cells (PBMCs). However, due to their low proportion in [...] Read more.
The COVID-19 pandemic has made assessing vaccine efficacy more challenging. Besides neutralizing antibody assays, systems vaccinology studies use omics technology to reveal immune response mechanisms and identify gene signatures in human peripheral blood mononuclear cells (PBMCs). However, due to their low proportion in PBMCs, profiling the immune response signatures of dendritic cells (DCs) is difficult. Here, we develop a predictive model for evaluating early immune responses in dendritic cells. We establish a THP-1-derived dendritic cell (TDDC) model and stimulate their maturation in vitro with an optimal dose of attenuated yellow fever 17D (YF-17D). Transcriptomic analysis reveals that type I interferon (IFN-I)-induced immunity plays a key role in dendritic cells. IFN-I regulatory biomarkers (IRF7, SIGLEC1) and IFN-I-inducible biomarkers (IFI27, IFI44, IFIT1, IFIT3, ISG15, MX1, OAS2, OAS3) are identified and validated in vitro and in vivo. Furthermore, we apply this TDDC approach to various types of vaccines, providing novel insights into their early immune response signatures and their heterogeneity in vaccine recipients. Our findings suggest that a standardizable TDDC model is a promising predictive approach to assessing early immunity in DCs. Further research into vaccine efficacy assessment approaches on various types of immune cells could lead to a systemic regimen for vaccine development in the future. Full article
(This article belongs to the Special Issue Recent Advances in Molecular Materials and Biomedicine)
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12 pages, 5176 KiB  
Article
Development of Detection Antibody Targeting the Linear Epitope in SARS-CoV-2 Nucleocapsid Protein with Ultra-High Sensitivity
by Feng Wu, Yike Jiang, Hongtian Yang and Lan Ma
Int. J. Mol. Sci. 2024, 25(8), 4436; https://doi.org/10.3390/ijms25084436 - 18 Apr 2024
Viewed by 489
Abstract
The COVID-19 pandemic caused by SARS-CoV-2 highlighted the importance of reliable detection methods for disease control and surveillance. Optimizing detection antibodies by rational screening antigens would improve the sensitivity and specificity of antibody-based detection methods such as colloidal gold immunochromatography. In this study, [...] Read more.
The COVID-19 pandemic caused by SARS-CoV-2 highlighted the importance of reliable detection methods for disease control and surveillance. Optimizing detection antibodies by rational screening antigens would improve the sensitivity and specificity of antibody-based detection methods such as colloidal gold immunochromatography. In this study, we screened three peptide antigens with conserved sequences in the N protein of SARS-CoV-2 using bioinformatical and structural biological analyses. Antibodies that specifically recognize these peptides were prepared. The epitope of the peptide that had the highest binding affinity with its antibody was located on the surface of the N protein, which was favorable for antibody binding. Using the optimal antibody that can recognize this epitope, we developed colloidal gold immunochromatography, which can detect the N protein at 10 pg/mL. Importantly, this antibody could effectively recognize both the natural peptide antigen and mutated peptide antigen in the N protein, showing the feasibility of being applied in the large-scale population testing of SARS-CoV-2. Our study provides a platform with reference significance for the rational screening of detection antibodies with high sensitivity, specificity, and reliability for SARS-CoV-2 and other pathogens. Full article
(This article belongs to the Special Issue Recent Advances in Molecular Materials and Biomedicine)
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