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Dr. Rui Jiao

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Department of Food Science and Engineering, Institute of Food Safety and Nutrition, Jinan University, Guangzhou 510632, China
Interests: functional food and nutraceuticals; lipid metabolism; metabolic disease; obesity; hypercholesterolemia

Special Issue Information

Dear Colleagues,

Lipids such as triglycerides, fatty acids, cholesterol and phospholipids play various essential roles in the human body. Dysregulation of lipid metabolism causes dyslipidemia, which is a critical factor in many kinds of human diseases, such as obesity, non-alcoholic fatty liver disease, atherosclerosis, cardiovascular disease, type II diabetes, Alzheimer’s disease, and even COVID-19.

In recent years, nutraceuticals and functional foods have attracted much interest as possible alternative therapies for lipid disorders, especially for hypercholesterolemia, hypertriglyceridemia, mixed hyperlipoproteinemia, and low HDL cholesterol.

Contributions to this Special Issue will provide new insights into the impact of food nutrition in the prevention of lipid disorders and their related diseases. Regulation of lipid-metabolism-related genes and proteins are also discussed in this Special Issue.

Dr. Rui Jiao
Guest Editor

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Keywords

food nutrition
lipid metabolism
cholesterol
triglyceride
functional food
nutraceuticals
dietary patterns
cardiovascular disease
obesity
diabetes
COVID-19
molecular nutrition

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Review

24 pages, 4489 KiB

Open AccessReview

The Effect of Fenugreek in Type 2 Diabetes and Prediabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

by Jiwon Kim, Woojeong Noh, Ahrim Kim, Yoomin Choi and Young-Sik Kim

Int. J. Mol. Sci. 2023, 24(18), 13999; https://doi.org/10.3390/ijms241813999 - 12 Sep 2023

Viewed by 2256

Abstract

Fenugreek is a widely used herbal medicine as a complementary therapy for diabetes mellitus. Lots of clinical trials have proved its beneficial effect on glycemic control parameters and lipid profiles. Thus, we conducted a systematic review and meta-analysis to evaluate the effectiveness and safety of fenugreek as a treatment for type 2 diabetes mellitus. We searched PubMed, Embase, Cochrane, China Knowledge Resource Integrated Database (CNKI), Korean studies Information Service System (KISS), Research Information Sharing Service (RISS), and ScienceON to select RCTs which used fenugreek targeting hyperglycemia with a control group. We used either a random effect model or a fixed model in a meta-analysis of Fasting blood glucose (FBG), 2 h plasma glucose during a 75 g oral glucose tolerance test (OGTT) (2-hPG), homeostatic model assessment for insulin resistance (HOMA-IR), glycosylated hemoglobin (HbA1c)/total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL-C), low density lipoprotein (LDL-C), body mass index (BMI). After screening, a total of 10 studies (706 participants) remained. Fenugreek significantly reduced FBG, 2-hPG, and HbA1c, but it did not significantly decrease HOMA-IR. Moreover, it significantly improved TC, TG, and HDL-C, while there were no significant differences in LDL-C and BMI. Hepatic or renal toxicity was not observed, and there were no severe adverse events associated with fenugreek despite mild gastrointestinal side effects in some studies. In conclusion, fenugreek improves overall glycemic control parameters and lipid profile safely. Full article

(This article belongs to the Special Issue Food Nutrition and Lipid Metabolism)

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