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New Advances in Epigenetics and Epigenomics

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 616

Special Issue Editor


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Guest Editor
School of Medicine and Public Health, The University of Newcastle, Newcastle, Australia
Interests: epigenetics; epigenomics; epitranscriptomics

Special Issue Information

Dear Colleagues,

Epigenetic changes have been implicated in various diseases such as cancer, neurodegenerative conditions, autoimmune disease and cardiovascular disease. Epigenetics refers to heritable changes in gene function that do not involve changes to the underlying DNA sequence, and epigenomics is the study of these changes across the entire genome. In recent years, advances in high-throughput sequencing technology, genome editing and multi-omics analysis have facilitated the study of epigenetic changes. This Special Issue will focus on studies utilizing advances in epigenetics and epigenomics including, but not limited to, single-cell epigenomics, CRISPR-based epigenomic editing, DNA methylation and demethylation dynamics, epitranscriptomics and the integration of epigenomic data with other “omics” fields.

Dr. Vicki Maltby
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • epigenetics
  • epigenomics
  • multi-omics
  • epitranscriptomics
  • single cell

Published Papers (1 paper)

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Review

14 pages, 1483 KiB  
Review
Additional Sex Combs-like Family Associated with Epigenetic Regulation
by Nackhyoung Kim, Sukyoung Byun and Soo-Jong Um
Int. J. Mol. Sci. 2024, 25(10), 5119; https://doi.org/10.3390/ijms25105119 - 8 May 2024
Viewed by 351
Abstract
The additional sex combs-like (ASXL) family, a mammalian homolog of the additional sex combs (Asx) of Drosophila, has been implicated in transcriptional regulation via chromatin modifications. Abnormal expression of ASXL family genes leads to myelodysplastic syndromes and various types of [...] Read more.
The additional sex combs-like (ASXL) family, a mammalian homolog of the additional sex combs (Asx) of Drosophila, has been implicated in transcriptional regulation via chromatin modifications. Abnormal expression of ASXL family genes leads to myelodysplastic syndromes and various types of leukemia. De novo mutation of these genes also causes developmental disorders. Genes in this family and their neighbor genes are evolutionary conserved in humans and mice. This review provides a comprehensive summary of epigenetic regulations associated with ASXL family genes. Their expression is commonly regulated by DNA methylation at CpG islands preceding transcription starting sites. Their proteins primarily engage in histone tail modifications through interactions with chromatin regulators (PRC2, TrxG, PR-DUB, SRC1, HP1α, and BET proteins) and with transcription factors, including nuclear hormone receptors (RAR, PPAR, ER, and LXR). Histone modifications associated with these factors include histone H3K9 acetylation and methylation, H3K4 methylation, H3K27 methylation, and H2AK119 deubiquitination. Recently, non-coding RNAs have been identified following mutations in the ASXL1 or ASXL3 gene, along with circular ASXLs and microRNAs that regulate ASXL1 expression. The diverse epigenetic regulations linked to ASXL family genes collectively contribute to tumor suppression and developmental processes. Our understanding of ASXL-regulated epigenetics may provide insights into the development of therapeutic epigenetic drugs. Full article
(This article belongs to the Special Issue New Advances in Epigenetics and Epigenomics)
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