G Protein-Coupled Receptor Signaling in Molecular and Cellular Physiology
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (20 April 2024) | Viewed by 3634
Special Issue Editor
Interests: cardiovascular G protein-coupled receptors (GPCRs); heart failure; autonomic control of the circulation; adrenal physiology and pharmacology; adrenergic receptors; angiotensin receptors; signal transduction; gene therapy; aldosterone pharmacology; GPCR-Kinases; arrestins; G protein signaling
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
G protein-coupled receptors (GPCRs), also known as heptahelical or seven transmembrane-spanning receptors, reside in the plasma membrane and enable various hormones and neurotransmitters to exert their actions on mammalian cells. These receptors are essential for the homeostasis of every mammalian multi-cellular organism because they mediate extracellular signals that are not lipophilic enough to pass through cell membranes to reach their intracellular targets. Therefore, it is not surprising that GPCRs constitute the single largest pharmaceutical target class, modulating various aspects of cellular and tissue physiology, but also playing important roles in pathological situations/human diseases that arise from perturbations in cellular physiology. The greatest testament to the significance of these receptors for human physiology and disease is the fact that more than one third of all drugs currently used in clinical practice are direct ligands (agonists, antagonists and inverse agonists) of this class of receptors.
This Special Issue of “Int. J. Mol. Sci.” is inviting articles that discuss the most recent advances in various specific topics related to the roles of GPCRs in human physiology and disease at the molecular, cellular, and/or organ/system levels.
The specific topics include (but are not limited to) the following:
- GPCR signal transduction;
- GPCR signaling regulation or termination;
- GPCRs and cell nucleus (DNA transcription, cell cycle and division; DNA damage response);
- GPCRs in adipose tissue (fat) cells;
- GPCRs in astrocytes and microglia;
- GPCRs in cardiac myocytes;
- GPCRs in endocrine glands (pituitary, thyroid, parathyroid, adrenals and pancreas);
- GPCRs in cells of the GI tract;
- GPCRs in cells of the respiratory apparatus (bronchi; lungs);
- GPCRs in cellular aging;
- GPCRs in cellular energetics/mitochondrial metabolism;
- GPCRs in cellular oxidative stress;
- GPCRs in female reproductive organ cells (uterus; ovaries);
- GPCRs in fibroblasts;
- GPCRs in immune and inflammatory cells;
- GPCRs in male reproductive organ cells (testes, prostate; urinary bladder);
- GPCRs in malignant cells/cancer;
- GPCRs in neurons of the autonomic nervous system;
- GPCRs in neurons of the central nervous system (CNS)/brain;
- GPCRs in the liver ;
- GPCRs in renal cells;
- GPCRs in stem cell physiology;
- GPCRs in vascular endothelial cells;
- GPCRs in vascular smooth muscle cells;
- Sex differences in GPCR function/physiology.
Dr. Anastasios Lymperopoulos
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Keywords
- GPCR
- signal transduction
- molecular physiology
- disease
- cellular pathophysiology
