The NLRP3-Inflammasome in Health and Disease 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 31 May 2024 | Viewed by 2419
Special Issue Editor
Interests: cancer endocrinology; molecular biology; signal transduction; p75NTR-signaling; apoptosis; autophagy; EMT; renal and peritoneal fibrosis; inflammation; biological activity of natural compounds in cancer and chronic diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
NLRP3 inflammasome is a key component of the innate immune system, which is activated by a wide range of pathogen-, host-, and environment-derived molecules. NLRP3 inflammasome activation occurs through a canonical and non-canonical pathway. In this, the culminant event is the production of active caspase-1, which is able to process pro-IL-1β into its mature protein, IL-1β, that, in turn, is considered a crucial mediator of inflammation. However, the physiological role of NLRP3 in healthy individuals remains incompletely understood.
In the last decades, many in vitro and in vivo studies have demonstrated that the aberrant NLRP3 activation is strongly involved in the pathogenesis of prevalent diseases, including inflammatory bowel disease, coronary heart disease, chronic kidney disease, autoimmune diseases, neurodegenerative diseases, and cancer. Furthermore, genetic studies uncovered mutations or genetic variants in NLRP3 inflammasome components, conferring the susceptibility for diseases, such as diabetes and systemic inflammation. Recently, it has been proposed that dysregulated epigenetic mechanisms may contribute to the clinical manifestations of autoinflammatory syndromes by upregulating the expression of inflammasome components.
Therefore, it is our pleasure to invite investigators to contribute to this Special Issue with original research articles, aimed to better elucidate the current knowledge of the physiological and pathophysiological mechanisms of NLRP3 inflammasome activation in health and diseases and to propose new therapeutic approaches targeting the NLRP3 inflammasome.
Dr. Anna Perri
Guest Editor
Manuscript Submission Information
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Keywords
- NLRP3-inflammasome
- mitochondrial dysfunction
- oxidative stress
- IL-1β – IL-18
- genetic variants of NLRP3 inflammasome
