ijms-logo

Journal Browser

Journal Browser

Hypertension and Dyslipidemia: From Pathogenesis to Therapeutic Perspective

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (30 December 2023) | Viewed by 3759

Special Issue Editor


E-Mail Website
Guest Editor
Department of Mechanics and Mathematics, Russian State Social University, Moscow 119992, Russia
Interests: platelets; animal physiology; ontogenesis; cardiology; arterial hypertension; metabolic disorders
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

Recently, among the population of developed countries, arterial hypertension is increasingly common, which is aggravated by dyslipidemia. Isolated arterial hypertension causes many different disorders in the body. In the case of its combination with dyslipidemia, the number of disorders increases even more, and the risk of vascular complications increases many times over. In this condition, the development of atherosclerosis in different vascular regions is intensified, the mechanisms of hemostasis are disrupted, which creates conditions for the occurrence of vascular complications. The active treatment used for arterial hypertension and dyslipidemia is far from being effective in all cases, and these patients often lose their ability to work and become disabled. For this reason, it is important to continue studying aspects of the pathogenesis of the combination of arterial hypertension and dyslipidemia and approaches to its correction.

Dr. Ilya Nikolaevich Medvedev
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • arterial hypertension
  • dyslipidemia
  • complication of the disease
  • vascular disorders
  • hemostasiopathy
  • thrombosis
  • antihypertensive therapy
  • lipid-lowering therapy
  • exercise
  • dietary treatment

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

21 pages, 1563 KiB  
Review
Omega-3 Fatty Acids in Arterial Hypertension: Is There Any Good News?
by Gabriele Brosolo, Andrea Da Porto, Stefano Marcante, Alessandro Picci, Filippo Capilupi, Patrizio Capilupi, Nicole Bertin, Cinzia Vivarelli, Luca Bulfone, Antonio Vacca, Cristiana Catena and Leonardo A. Sechi
Int. J. Mol. Sci. 2023, 24(11), 9520; https://doi.org/10.3390/ijms24119520 - 30 May 2023
Cited by 4 | Viewed by 3287
Abstract
Omega-3 polyunsaturated fatty acids (ω-3 PUFAs), including alpha-linolenic acid (ALA) and its derivatives eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are “essential” fatty acids mainly obtained from diet sources comprising plant oils, marine blue fish, and commercially available fish oil supplements. Many epidemiological [...] Read more.
Omega-3 polyunsaturated fatty acids (ω-3 PUFAs), including alpha-linolenic acid (ALA) and its derivatives eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are “essential” fatty acids mainly obtained from diet sources comprising plant oils, marine blue fish, and commercially available fish oil supplements. Many epidemiological and retrospective studies suggested that ω-3 PUFA consumption decreases the risk of cardiovascular disease, but results of early intervention trials have not consistently confirmed this effect. In recent years, some large-scale randomized controlled trials have shed new light on the potential role of ω-3 PUFAs, particularly high-dose EPA-only formulations, in cardiovascular prevention, making them an attractive tool for the treatment of “residual” cardiovascular risk. ω-3 PUFAs' beneficial effects on cardiovascular outcomes go far beyond the reduction in triglyceride levels and are thought to be mediated by their broadly documented “pleiotropic” actions, most of which are directed to vascular protection. A considerable number of clinical studies and meta-analyses suggest the beneficial effects of ω-3 PUFAs in the regulation of blood pressure in hypertensive and normotensive subjects. These effects occur mostly through regulation of the vascular tone that could be mediated by both endothelium-dependent and independent mechanisms. In this narrative review, we summarize the results of both experimental and clinical studies that evaluated the effect of ω-3 PUFAs on blood pressure, highlighting the mechanisms of their action on the vascular system and their possible impact on hypertension, hypertension-related vascular damage, and, ultimately, cardiovascular outcomes. Full article
Show Figures

Figure 1

Back to TopTop