Human Cell Infection and Host-Pathogen Interaction
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".
Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 987
Special Issue Editor
Interests: intensive care medicine; host–pathogen interactions; mycology; immunology; invasive fungal disease
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Microbial infections are one of the biggest threats for critically ill patients. They involve a complex interplay between these microorganisms, the environment, and the host. Several efforts have been made to uncover the underlying mechanisms of these infections and to answer the question as to why commensal bacteria or fungi turn intopathogens. Research often focusses on the pathogen side, identifying genetic prototypes responsible for pathogenicity. This view is probably too narrow, since the host's state of immunity plays a pivotal role for the development of severe microbial infections as well. Commensal fungi, such as Candida spp. or Aspergillus spp., can cause life-threatening invasive infections in immunosuppressed patients, whereas immune-competent patients are able to prevent the invasive growth of these commensals. The reason why immunocompetent hosts become susceptible to a former “apathogenic” microorganism during a state of critical illness is not yet fully understood. Therefore, the communication between the host and microbes as well as the interplay between different kinds of microorganisms has to be considered in more detail.
Advancements in the diagnostic workup of these serious diseases could lead to new treatment options and might potentially improve the still devastating outcomes of this vulnerable patient group. Understanding the development and the course of the disease could lead to an improved diagnostic accuracy.
This Special Issue aims to publish high-quality original research, including case reports, reviews, and short communications, concerning up-to-date microbial diagnostic techniques, biomarkers and future molecular imaging techniques such as omics and extracellular vehicles (EVs). We welcome translational research, including immunogenetic risk profiling and pathomechanisms which influence the course of all sorts of microbial infections in human cells (viral, bacterial, fungal and protozoans) and their host–pathogen interactions.
Dr. Simon Dubler
Guest Editor
Manuscript Submission Information
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Keywords
- immune response
- host–pathogen interactions
- virulence factor
- genome editing
- mycovirus infection
- fungal–host interactions
- new insight
- -omics
- pathogens
- critically ill
- immunosuppression
- cellular signalling
- bacteria
- virus
- host
