Sex Determination Mechanisms and Disease 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 2766
Special Issue Editor
Interests: sex determination; disorderes of sexual development – DSD; germ cells; posttrancriptional gene regulation – PTGR; RNA-binidng proteins – RBPs; 3’Utranslated region – 3’UTR
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Sex determination is one of the major developmental fate decisions that occur early in embryos by imposing male or female phenotypic sex on the whole individual; this process is critical especially in the context of frequent congenital sex development disorders/differences (DSD). These conditions are linked with several serious health and social problems from sex assignment at birth and trobles in pubertal development to infertility, increased susceptibility to testicular or ovarian cancer and bone health in adulthood. Albeit the molecular basis of DSD is only partially known, the advances in molecular biology permitt day-to-day discovery of new genes regulating sex determination and differentiation. The proposed Special Issue is focused on two main points. The first one is identification of novel genes which are involved in sex development and genomic mutations underlying the various phenotypes. The second point is to uncover roles of these novel genes and their functional relationship in the processes governing human sex development. Endocrynological aspects as well as any other topics related to sex development, DSD and their clinical managent through lifespan are welcome.
Dr. Jadwiga Jaruzelska
Guest Editor
Manuscript Submission Information
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Keywords
- sex determination
- disorders of sex development
- sex ambiguity
- gonadal development
- endocrinology of sex development
