Drosophila: A Model System for Human Disease Research
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 161
Special Issue Editor
Interests: cancer genetics; MYC-mediated cell competition; model tumourigenesis
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Special Issue Information
Dear Colleagues,
The fruit fly Drosophila melanogaster has been proven to be a golden model for basic biological research. Over the years, its potential as a tool for deciphering the molecular networks at the basis of human disease has become more and more acknowledged. Uninterrupted efforts of the Drosophila research community have been dedicated to developing new genetic systems aimed at investigating organ, tissue and cellular processes with an increasing level of precision. As a result, the fruit fly now serves as a model not only for basic genetic research, but also for an extraordinarily diverse series of human diseases, from cancer to neurodegeneration and from developmental disorders to drug discovery. As cellular and molecular mechanisms governing organogenesis have been shown to be highly conserved between Drosophila and humans, and given that the fruit fly has functional homologues of most parts of human disease genes, we anticipate that this aspect of Drosophila research will definitely expand in the future.
We invite investigators to contribute original research articles, as well as review articles and opinion papers, that address genetic and molecular mechanisms involved in human disease using the Drosophila model.
Dr. Daniela Grifoni
Guest Editor
Manuscript Submission Information
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Keywords
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developmental disease
- metabolic disease
- organ disease
- stem cells and regenerative medicine
- cancer models
- neurodegeneration
- drug discovery and screening
