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Drosophila: A Model System for Human Disease Research

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 197

Special Issue Editor

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Guest Editor
Dipartimento di Medicina Clinica, Sanità Pubblica, Scienze della Vita e dell’Ambiente, Università Dell’Aquila, 67100 L’Aquila, Italy
Interests: cancer genetics; MYC-mediated cell competition; model tumourigenesis
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Special Issue Information

Dear Colleagues,

The fruit fly Drosophila melanogaster has been proven to be a golden model for basic biological research. Over the years, its potential as a tool for deciphering the molecular networks at the basis of human disease has become more and more acknowledged. Uninterrupted efforts of the Drosophila research community have been dedicated to developing new genetic systems aimed at investigating organ, tissue and cellular processes with an increasing level of precision. As a result, the fruit fly now serves as a model not only for basic genetic research, but also for an extraordinarily diverse series of human diseases, from cancer to neurodegeneration and from developmental disorders to drug discovery. As cellular and molecular mechanisms governing organogenesis have been shown to be highly conserved between Drosophila and humans, and given that the fruit fly has functional homologues of most parts of human disease genes, we anticipate that this aspect of Drosophila research will definitely expand in the future.

We invite investigators to contribute original research articles, as well as review articles and opinion papers, that address genetic and molecular mechanisms involved in human disease using the Drosophila model.

Dr. Daniela Grifoni
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • developmental disease

  • metabolic disease
  • organ disease
  • stem cells and regenerative medicine
  • cancer models
  • neurodegeneration
  • drug discovery and screening

Published Papers

This special issue is now open for submission.
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