Centrosomes and Microtubule-Organizing Centers
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 2090
Special Issue Editors
Interests: centrosomes; centrioles; protein kinases; stress RNP granules; Golgi apparatus; microtubules; intermediate filaments
Special Issue Information
Dear Colleagues,
Microtubules in cells usually emerge from special seeds, with which they remain connected by minus ends. The seed is usually a γ-tubulin ring complex (γTuRC), but microtubules may also form. The seeds are usually assembled into compact structures in the cells called microtubule-organizing centers (MTOCs). In animal cells, the most developed MTOC is the centrosome. The centrosome consists of centrioles surrounded by fibro-granular pericentriolar material to which the γTuRCs are attached. In addition to organizing the pericentriolar material, centrioles are required for the formation of cilia and flagella. It is not uncommon for cells to form additional MTOCs when γTuRCs accumulate on the Golgi apparatus, the nuclear envelope, or near the plasmalemma. Many fungi and algae do not have a centrosome, but they have a spindle pole body or similar structure, a protein aggregate that also accumulates γTuRC and serves as an MTOC. Despite intensive research, details about the formation of MTOC remain unclear. Thus, out understanding of γTuRC attachment to the pericentriolar material and other cell contents, γTuRC activation, and the mechanisms of the accumulation of pericentriolar material around the centrioles are unclear. The assembly process of centrioles at the molecular level remains largely enigmatic. Disturbances in MTOC formation can lead to spindle dysfunction and chromosomal abnormalities in mitosis or to cilia/flagella abnormity in the interphase.
This Special Issue of IJMS aims to provide our current understanding of MTOC and centrosome formation and functioning at the molecular level. We are seeking original research papers and review articles related to this aspect of the microtubular part of cytoskeleton organization.
Prof. Dr. Elena S. Nadezhdina
Dr. Anton V. Burakov
Guest Editors
Manuscript Submission Information
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Keywords
- centrosome
- centriole
- pericentriolar material
- microtubule-organizing center
- MTOC
- γTuRC
- spindle pole body
- microtubule anchoring
