Demyelinating Diseases: From Molecular Mechanisms to, Therapeutic Strategies 3.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 31 July 2024 | Viewed by 2194
Special Issue Editor
Interests: neuroscience; neurodegenerative disease; myelination and remyelination; oligodendrocytes; signal transduction
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This is the third Special Issue in the continued series focused on the hot topic of demyelinating diseases. We have already launched two successful Special Issues which received interesting contributions and discussions (https://www.mdpi.com/journal/ijms/special_issue/demyelinating_diseases; https://www.mdpi.com/journal/ijms/special_issues/HZ6L4ZMBB7).
Demyelinating diseases are a group of pathologies characterized by the alteration of myelin, that is, the coating that wraps most of the nerve fibers of the central and peripheral nervous system, whose goal is to improve nerve conduction and the preservation of energy spent during action potential propagation. They are very disabling diseases, affecting millions of people worldwide. There are different types of demyelinating disorders, each characterized by peculiar characteristics that allow for their classification. A broad classification of demyelinating diseases is drawn according to their pathogenesis, including the following categories: due to immune-mediated inflammatory processes, infectious diseases, caused by metabolic disorders, and hypoxic-ischaemic forms. The myelin produced by oligodendrocytes in the central nervous system (CNS) differs in terms of chemical and immunological features from that provided in the peripheral nervous system (PNS) by Schwann cells. Accordingly, some demyelinating diseases mainly affect the peripheral nerves, while others primarily affect the CNS. In most cases, however, there is no effective pharmacological treatment capable of completely restoring the normal functionality of myelin and nerve conduction.
The aim of this Special Issue, entitled “Demyelinating Diseases: From Molecular Mechanisms to, Therapeutic Strategies 3.0”, is dual: to offer an overview on the landscape of research devoted to deepening knowledge on the pathogenic mechanisms involved in demyelinating diseases and to gather an ensemble of the efforts aimed at the identification and pre-clinical validation of targets for therapeutic approaches to be utilized in preventive or curing strategies to improve the quality of life of patients suffering from these severe pathologies. Experimental papers on in vitro or ex vivo models, up-to-date review articles, and commentaries are all welcome.
Dr. Antonietta Bernardo
Guest Editor
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Keywords
- biomarkers
- cellular and molecular biology
- cell differentiation
- cellular metabolism
- demyelinating diseases
- drug developing strategies and drug repositioning
- glia cell (oligodendrocytes, astrocytes and microglia)
- inflammation
- lipid metabolism
- mitochondria
- myelination and remyelination nuclear receptors
- nutraceuticals
- signal transduction mechanisms
- target identification
