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Cell Death in Biology and Diseases 3.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 20 May 2024 | Viewed by 1261

Special Issue Editors


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Guest Editor
Gravitational Biology Group, Department of Biology, Cell Biology Division, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91058 Erlangen, Germany
Interests: cell biology; plant physiology; photodynamic therapy
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Environmental Cell Biology Group, Department of Microgravity and Translational Regenerative Medicine, Otto von Guericke University, 39106 Magdeburg, Germany
Interests: cell biology; cancer biology; environmental influences; microgravity; cellular communication; photodynamic therapy; cancer treatment; antimicrobial resistance; tumor microbiome
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cell death is a major biological phenomenon. Like other cellular processes (e.g., cell proliferation or cell differentiation), cell death is a choice that a cell has to make—sometimes voluntarily, other times accidentally. Cell death serves a purpose in the biology of multicellular organisms. However, the machinery for cell death is evolutionarily conserved, and the elements can also be found in single-celled organisms. The molecular mechanisms of cell death (or conversely cell survival) are complex and often closely connected to other cellular processes, such as cell proliferation or differentiation, and are thus part of a broad signaling network. The disruption of these mechanisms often causes developmental abnormalities, and factors that trigger cell death can directly contribute to the pathogenesis of many diseases, including cancer, neurodegenerative diseases, and tissue injury. Additionally, in plants, programmed cell death plays an important role in the formation of sclerenchyma and xylem (water and mineral transport).

This Special Issue will focus on the exploration of the role of cell death in disease development and the modulation of cell death for the treatment of diseases, as it is important that our knowledge in this field is constantly updated. This Special Issue highly welcomes original research articles, short communications, and review manuscripts. Interdisciplinary contributions will help to get a detailed overview of this exciting research field in medicine, pest control, and other areas, providing great opportunities for new discoveries and applications in life science.

Dr. Peter Richter
Dr. Marcus Krüger
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • programmed cell death
  • apoptosis
  • necrosis
  • autoimmune diseases
  • cancer research
  • pharmacognosy
  • photodynamic therapy
  • immune system

Published Papers (1 paper)

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Research

19 pages, 3752 KiB  
Article
Photodynamic Activity of Chlorophyllin and Polyethylenimine on Pseudomonas aeruginosa Planktonic, Biofilm and Persister Cells
by Mona Mahmoud, Peter Richter, Michael Lebert and Andreas Burkovski
Int. J. Mol. Sci. 2023, 24(15), 12098; https://doi.org/10.3390/ijms241512098 - 28 Jul 2023
Viewed by 867
Abstract
Antimicrobial photodynamic inactivation is considered a promising antimicrobial approach that may not develop resistance in the near future. Here, we investigate the influence of the photosensitizer chlorophyllin (CHL) and the cationic permeabilizer polyethylenimine (PEI), exposed to a red light-emitting diode, on the human [...] Read more.
Antimicrobial photodynamic inactivation is considered a promising antimicrobial approach that may not develop resistance in the near future. Here, we investigate the influence of the photosensitizer chlorophyllin (CHL) and the cationic permeabilizer polyethylenimine (PEI), exposed to a red light-emitting diode, on the human pathogen Pseudomonas aeruginosa free-living planktonic cells, the sessile biofilm and persister cells. The broth microdilution checkerboard method was used to test antimicrobial susceptibility. As a substrate for biofilms, the Calgary biofilm device was used, and the quantification of the biofilm biomass was carried out using a crystal violet assay. Serine hydroxamate was used for the induction of persisters. Our findings reveal that PEI ameliorates the antimicrobial activity of CHL against P. aeruginosa planktonic and biofilm states, and the concentration required to eradicate the bacteria in the biofilm is more than fourfold that is required to eradicate planktonic cells. Interestingly, the persister cells are more susceptible to CHL/PEI (31.25/100 µg mL−1) than the growing cells by 1.7 ± 0.12 and 0.4 ± 0.1 log10 reduction, respectively, after 15 min of illumination. These data demonstrate that CHL excited with red light together with PEI is promising for the eradication of P. aeruginosa, and the susceptibility of P. aeruginosa to CHL/PEI is influenced by the concentrations and the exposure time. Full article
(This article belongs to the Special Issue Cell Death in Biology and Diseases 3.0)
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