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Metabolic Diseases and Complications in Association with Organ Cross-Talk
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Metabolic Diseases and Complications in Association with Organ Cross-Talk

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 2425

Special Issue Editor

Prof. Dr. Sang Geon Kim

E-Mail Website
Guest Editor
College of Pharmacy, Dongguk University-Seoul, Goyang 10326, Kyeonggi-do, Republic of Korea
Interests: diabetes; complications; NASH; fibrosis; new drug development; metabolic diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Metabolic diseases represent a complex and diverse group of disorders that significantly impact the overall health and quality of life for millions of individuals worldwide. These conditions encompass a wide range of disorders involving disruptions in energy metabolism, nutrient utilization, and hormonal regulation, contributing to a myriad of adverse health outcomes. This Special Issue on “Metabolic Diseases and Complications in Association with Organ Cross-talk" aims to provide a comprehensive platform for the dissemination of cutting-edge research, breakthroughs, and insights in the field of metabolic diseases.

The goal of this Special Issue is to showcase the latest advancements in the understanding, basis and applications for the treatment of metabolic diseases, fostering interdisciplinary collaboration and knowledge exchange among researchers and experts in various related fields.

  1. Molecular Mechanisms: Investigating the intricate molecular and cellular mechanisms underlying metabolic diseases, including metabolic syndrome, diabetes, obesity, and lipid disorders. Papers exploring genetic and epigenetic factors, signaling pathways, and molecular targets are encouraged.
  2. Therapeutic Innovations: Showcasing breakthrough therapeutic strategies for the management and treatment of metabolic diseases. This includes pharmacological interventions and nutritional approaches.
  3. Gut biology and Metabolism: Exploring the intricate relationship between the gut microbiome, metabolic pathways, and their influence on metabolic health.
  4. Metabolic Complications: Addressing the complex interplay between metabolic diseases and associated complications, such as cardiovascular diseases, renal disorders, and neurodegenerative conditions.
  5. Translational Research: Bridging the gap between basic research and clinical application by featuring studies that translate laboratory findings into real-world solutions for patients with metabolic disorders.

We encourage researchers and experts from various disciplines to contribute their valuable insights to collectively advance the field and improve the lives of individuals affected by metabolic diseases.

Prof. Dr. Sang Geon Kim
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolic syndrome
  • diabetes
  • obesity
  • lipid disorders
  • gut biology and metabolism
  • therapeutic innovations
  • metabolic complications
  • translational research

Published Papers (2 papers)

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Research

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17 pages, 3114 KiB  
Article
Lipidomics Reveals Myocardial Lipid Composition in a Murine Model of Insulin Resistance Induced by a High-Fat Diet
by Josefa Girona, Oria Soler, Sara Samino, Alexandra Junza, Neus Martínez-Micaelo, María García-Altares, Pere Ràfols, Yaiza Esteban, Oscar Yanes, Xavier Correig, Lluís Masana and Ricardo Rodríguez-Calvo
Int. J. Mol. Sci. 2024, 25(5), 2702; https://doi.org/10.3390/ijms25052702 - 26 Feb 2024
Viewed by 683
Abstract
Ectopic fat accumulation in non-adipose tissues is closely related to diabetes-related myocardial dysfunction. Nevertheless, the complete picture of the lipid metabolites involved in the metabolic-related myocardial alterations is not fully characterized. The aim of this study was to characterize the specific lipid profile [...] Read more.
Ectopic fat accumulation in non-adipose tissues is closely related to diabetes-related myocardial dysfunction. Nevertheless, the complete picture of the lipid metabolites involved in the metabolic-related myocardial alterations is not fully characterized. The aim of this study was to characterize the specific lipid profile in hearts in an animal model of obesity/insulin resistance induced by a high-fat diet (HFD). The cardiac lipidome profiles were assessed via liquid chromatography–mass spectrometry (LC–MS)/MS-MS and laser desorption/ionization–mass spectrometry (LDI–MS) tissue imaging in hearts from C57BL/6J mice fed with an HFD or standard-diet (STD) for 12 weeks. Targeted lipidome analysis identified a total of 63 lipids (i.e., 48 triacylglycerols (TG), 5 diacylglycerols (DG), 1 sphingomyelin (SM), 3 phosphatidylcholines (PC), 1 DihydroPC, and 5 carnitines) modified in hearts from HFD-fed mice compared to animals fed with STD. Whereas most of the TG were up-regulated in hearts from animals fed with an HFD, most of the carnitines were down-regulated, thereby suggesting a reduction in the mitochondrial β-oxidation. Roughly 30% of the identified metabolites were oxidated, pointing to an increase in lipid peroxidation. Cardiac lipidome was associated with a specific biochemical profile and a specific liver TG pattern. Overall, our study reveals a specific cardiac lipid fingerprint associated with metabolic alterations induced by HFD. Full article
(This article belongs to the Special Issue Metabolic Diseases and Complications in Association with Organ Cross-Talk)
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Review

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25 pages, 2489 KiB  
Review
Intestinal Inflammation and Regeneration–Interdigitating Processes Controlled by Dietary Lipids in Inflammatory Bowel Disease
by Soon Jae Kwon, Muhammad Sohaib Khan and Sang Geon Kim
Int. J. Mol. Sci. 2024, 25(2), 1311; https://doi.org/10.3390/ijms25021311 - 21 Jan 2024
Viewed by 1418
Abstract
Inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, is a disease of chronic inflammatory conditions of the intestinal tract due to disturbance of the inflammation and immune system. Symptoms of IBD include abdominal pain, diarrhea, bleeding, reduced weight, and fatigue. In [...] Read more.
Inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, is a disease of chronic inflammatory conditions of the intestinal tract due to disturbance of the inflammation and immune system. Symptoms of IBD include abdominal pain, diarrhea, bleeding, reduced weight, and fatigue. In IBD, the immune system attacks the intestinal tract’s inner wall, causing chronic inflammation and tissue damage. In particular, interlukin-6 and interlukin-17 act on immune cells, including T cells and macrophages, to amplify the immune responses so that tissue damage and morphological changes occur. Of note, excessive calorie intake and obesity also affect the immune system due to inflammation caused by lipotoxicity and changes in lipids supply. Similarly, individuals with IBD have alterations in liver function after sustained high-fat diet feeding. In addition, excess dietary fat intake, along with alterations in primary and secondary bile acids in the colon, can affect the onset and progression of IBD because inflammatory cytokines contribute to insulin resistance; the factors include the release of inflammatory cytokines, oxidative stress, and changes in intestinal microflora, which may also contribute to disease progression. However, interfering with de novo fatty acid synthase by deleting the enzyme acetyl-CoA-carboxylase 1 in intestinal epithelial cells (IEC) leads to the deficiency of epithelial crypt structures and tissue regeneration, which seems to be due to Lgr5+ intestinal stem cell function. Thus, conflicting reports exist regarding high-fat diet effects on IBD animal models. This review will focus on the pathological basis of the link between dietary lipids intake and IBD and will cover the currently available pharmacological approaches. Full article
(This article belongs to the Special Issue Metabolic Diseases and Complications in Association with Organ Cross-Talk)
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