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Metal-Based Drugs and Research on Mechanisms of Action
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Metal-Based Drugs and Research on Mechanisms of Action

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".

Deadline for manuscript submissions: closed (15 April 2024) | Viewed by 5354

Special Issue Editor

Prof. Dr. Elena K. Beloglazkina

E-Mail Website
Guest Editor
Department of Chemistry, M. V. Lomonosov Moscow State University, Leninskie Gory, 1-3, 119991 Moscow, Russia
Interests: cycloaddition reactions; organic ligands; medicinal chemistry; functional organic-inorganic materials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Metal-based drugs and imaging agents used for the treatment and diagnosis of cancers, diabetes, ulcers, rheumatoid arthritis, inflammatory and cardiovascular diseases, and bacterial infections have proven to be highly effective in clinics. The unique electronic structure of transition metals makes it possible to fine-tune the redox properties of molecules. Due to the wide variety of coordination spheres and ligand structures, coordination and organometallic compounds are able to exhibit high activity levels towards biological receptors. The mechanisms of the biological actions of metal complexes include enzyme inhibition, interactions with intracellular biomolecules, increased lipophilicity, changes in the functions of cell membranes, and cell cycle arrest.

The present Special Issue of the International Journal of Molecular Sciences will focus on recent “Metal-Based Drugs and Research on Mechanisms of Action”, including the development of new general and universal synthetic approaches to metal-containing compounds, the determination of their structure, and biological testing, establishing the mechanisms of their action and structure–activity ratio. Novel strategies intended to improve delivery methods can also be discussed in the research.

 Suitable topics include, but are not limited to, the following areas:

  • Synthesis of metal-based compounds;
  • Structural and biological investigation of metal-based compounds;
  • Establishing mechanisms of biological action;
  • Metal-based imaging agents.

Prof. Dr. Elena K. Beloglazkina
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • transition metals
  • metal complexes
  • metallodrugs
  • drug development
  • synthesis
  • imaging agents
  • structure–activity ratio

Published Papers (3 papers)

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Research

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16 pages, 1657 KiB  
Article
The Synthesis and Biological Activity of Organotin Complexes with Thio-Schiff Bases Bearing Phenol Fragments
by Ivan V. Smolyaninov, Andrey I. Poddel’sky, Daria A. Burmistrova, Yulia K. Voronina, Nadezhda P. Pomortseva, Maria A. Polovinkina, Nailya R. Almyasheva, Maria A. Zamkova, Nadezhda T. Berberova and Igor L. Eremenko
Int. J. Mol. Sci. 2023, 24(9), 8319; https://doi.org/10.3390/ijms24098319 - 05 May 2023
Cited by 4 | Viewed by 1679
Abstract
A number of novel di- and triorganotin(IV) complexes 1–5 (Ph2SnL1, Ph2SnL2, Et2SnL2, Ph3SnL3, Ph3SnL4) with mono- or dianionic forms of thio-Schiff [...] Read more.
A number of novel di- and triorganotin(IV) complexes 1–5 (Ph2SnL1, Ph2SnL2, Et2SnL2, Ph3SnL3, Ph3SnL4) with mono- or dianionic forms of thio-Schiff bases containing antioxidant sterically hindered phenol or catechol fragments were synthesized. Compounds 1–5 were characterized by 1H, 13C NMR, IR spectroscopy, and elemental analysis. The molecular structures of complexes 1 and 2 in the crystal state were established by single-crystal X-ray analysis. The antioxidant activity of new complexes as radical scavengers was estimated in DPPH and ABTS assays. It was found that compounds 4 and 5 with free phenol or catechol fragments are more active in these tests than complexes 1–3 with tridentate O,N,S-coordinated ligands. The effect of compounds 1–5 on the promoted oxidative damage of the DNA by 2,2’-azobis(2-amidinopropane) dihydrochloride and in the process of rat liver (Wistar) homogenate lipid peroxidation in vitro was determined. Complexes 4 and 5 were characterized by more pronounced antioxidant activity in the reaction of lipid peroxidation in vitro than compounds 1–3. The antiproliferative activity of compounds 1–5 was investigated against MCF-7, HTC-116, and A-549 cell lines by an MTT test. The values of IC50 are significantly affected by the presence of free antioxidant fragments and the coordination site for binding. Full article
(This article belongs to the Special Issue Metal-Based Drugs and Research on Mechanisms of Action)
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17 pages, 2694 KiB  
Article
New Titanocene (IV) Dicarboxylates with Potential Cytotoxicity: Synthesis, Structure, Stability and Electrochemistry
by Dmitry A. Guk, Karina R. Gibadullina, Roman O. Burlutskiy, Kirill G. Pavlov, Anna A. Moiseeva, Viktor A. Tafeenko, Konstantin A. Lyssenko, Erik R. Gandalipov, Alexander A. Shtil and Elena K. Beloglazkina
Int. J. Mol. Sci. 2023, 24(4), 3340; https://doi.org/10.3390/ijms24043340 - 07 Feb 2023
Cited by 3 | Viewed by 1422
Abstract
The search for new anticancer drugs based on biogenic metals, which have weaker side effects compared to platinum-based drugs, remains an urgent task in medicinal chemistry. Titanocene dichloride, a coordination compound of fully biocompatible titanium, has failed in pre-clinical trials but continues to [...] Read more.
The search for new anticancer drugs based on biogenic metals, which have weaker side effects compared to platinum-based drugs, remains an urgent task in medicinal chemistry. Titanocene dichloride, a coordination compound of fully biocompatible titanium, has failed in pre-clinical trials but continues to attract the attention of researchers as a structural framework for the development of new cytotoxic compounds. In this study, a series of titanocene (IV) carboxylate complexes, both new and those known from the literature, was synthesized, and their structures were confirmed by a complex of physicochemical methods and X-ray diffraction analysis (including one previously unknown structure based on perfluorinated benzoic acid). The comprehensive comparison of three approaches for the synthesis of titanocene derivatives known from the literature (the nucleophilic substitution of chloride anions of titanocene dichloride with sodium and silver salts of carboxylic acids as well as the reaction of dimethyltitanocene with carboxylic acids themselves) made it possible to optimize these methods to obtain higher yields of individual target compounds, generalize the advantages and disadvantages of these techniques, and determine the substrate frames of each method. The redox potentials of all obtained titanocene derivatives were determined by cyclic voltammetry. The relationship between the structure of ligands, the reduction potentials of titanocene (IV), and their relative stability in redox processes, as obtained in this work, can be used for the design and synthesis of new effective cytotoxic titanocene complexes. The study of the stability of the carboxylate-containing derivatives of titanocene obtained in the work in aqueous media showed that they were more resistant to hydrolysis than titanocene dichloride. Preliminary tests of the cytotoxicity of the synthesised titanocene dicarboxilates on MCF7 and MCF7-10A cell lines demonstrated an IC50 ≥ 100 μM for all the obtained compounds. Full article
(This article belongs to the Special Issue Metal-Based Drugs and Research on Mechanisms of Action)
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Review

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26 pages, 1862 KiB  
Review
Metal Nanomaterials and Hydrolytic Enzyme-Based Formulations for Improved Antifungal Activity
by Ilya Lyagin, Aysel Aslanli, Maksim Domnin, Nikolay Stepanov, Olga Senko, Olga Maslova and Elena Efremenko
Int. J. Mol. Sci. 2023, 24(14), 11359; https://doi.org/10.3390/ijms241411359 - 12 Jul 2023
Cited by 5 | Viewed by 1599
Abstract
Active research of metal-containing compounds and enzymes as effective antifungal agents is currently being conducted due to the growing antifungal resistance problem. Metals are attracting special attention due to the wide variety of ligands that can be used for them, including chemically synthesized [...] Read more.
Active research of metal-containing compounds and enzymes as effective antifungal agents is currently being conducted due to the growing antifungal resistance problem. Metals are attracting special attention due to the wide variety of ligands that can be used for them, including chemically synthesized and naturally obtained variants as a result of the so-called “green synthesis”. The main mechanism of the antifungal action of metals is the triggering of the generation and accumulation of reactive oxygen species (ROS). Further action of ROS on various biomolecules is nonspecific. Various hydrolytic enzymes (glucanases and proteases), in turn, exhibit antifungal properties by affecting the structural elements of fungal cells (cell walls, membranes), fungal quorum sensing molecules, fungal own protective agents (mycotoxins and antibiotics), and proteins responsible for the adhesion and formation of stable, highly concentrated populations in the form of biofilms. A wide substrate range of enzymes allows the use of various mechanisms of their antifungal actions. In this review, we discuss the prospects of combining two different types of antifungal agents (metals and enzymes) against mycelial fungi and yeast cells. Special attention is paid to the possible influence of metals on the activity of the enzymes and the possible effects of proteins on the antifungal activity of metal-containing compounds. Full article
(This article belongs to the Special Issue Metal-Based Drugs and Research on Mechanisms of Action)
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