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Omics Studies Focused on Fungal Secondary Metabolism
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Omics Studies Focused on Fungal Secondary Metabolism

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Microbial Genetics and Genomics".

Deadline for manuscript submissions: closed (28 February 2020) | Viewed by 18733

Special Issue Editors

Dr. Carlos García-Estrada

E-Mail Website
Guest Editor
1. Instituto de Biotecnología de León (INBIOTEC), León, Spain
2. Departamento de Ciencias Biomédicas, Facultad de Veterinaria, Campus de Vegazana, Universidad de León, 24071 León, Spain
Interests: fungal secondary metabolism; molecular biology; biotechnology; genetic engineering; omics
Special Issues, Collections and Topics in MDPI journals
Dr. Carlos Barreiro

E-Mail Website
Guest Editor
Área de Bioquímica y Biología Molecular, Departamento de Biología Molecular, Universidad de León, 24007 León, Spain
Interests: secondary metabolites; microorganisms; proteomics; plastics; actinobacteria; fungi; carotenoids; steroids; immunosuppressors; antibiotics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Fungi are capable of producing a huge array of molecules of different chemical natures, collectively named as secondary metabolites. Many of these natural products are well known and include from mycotoxins to pharmacologically active compounds, some of which have proven their relevance for human purposes. On the other hand, the fact that many fungal species are still underexplored, together with the presence of cryptic secondary metabolite gene clusters even in well-characterized fungal models, can give an idea about the huge potential of fungi as a natural source of products to be discovered and exploited.

During the last two decades, the incorporation of the “omics” methodologies to fungal secondary metabolism has dramatically increased the existing information about the genes and pathways leading to the biosynthesis of these compounds. Whole sequencing of different fungal genomes has paved the way for complex “omics” analyses aimed at deciphering the mechanisms that control the biosynthesis of secondary metabolites and establishing metabolic models for improved productivities.

This Special Issue welcomes submissions related to “omics” studies focused on fungal secondary metabolism, covering aspects of their biosynthesis and interconnected mechanisms, such as regulation, morphological differentiation, stress response, and biotic interactions.

Dr. Carlos García-Estrada
Dr. Carlos Barreiro
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Fungi
  • Secondary metabolism
  • Morphological differentiation
  • Stress response
  • Omics (genomics, transcriptomics, proteomics, metabolomics, etc.)

Published Papers (3 papers)

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Research

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12 pages, 1686 KiB  
Article
The velvet Regulator VosA Governs Survival and Secondary Metabolism of Sexual Spores in Aspergillus nidulans
by Min-Ju Kim, Mi-Kyung Lee, Huy Quang Pham, Myeong Ju Gu, Bohan Zhu, Sung-Hun Son, Dongyup Hahn, Jae-Ho Shin, Jae-Hyuk Yu, Hee-Soo Park and Kap-Hoon Han
Genes 2020, 11(1), 103; https://doi.org/10.3390/genes11010103 - 16 Jan 2020
Cited by 13 | Viewed by 3932
Abstract
The velvet regulator VosA plays a pivotal role in asexual sporulation in the model filamentous fungus Aspergillus nidulans. In the present study, we characterize the roles of VosA in sexual spores (ascospores) in A. nidulans. During ascospore maturation, the deletion [...] Read more.
The velvet regulator VosA plays a pivotal role in asexual sporulation in the model filamentous fungus Aspergillus nidulans. In the present study, we characterize the roles of VosA in sexual spores (ascospores) in A. nidulans. During ascospore maturation, the deletion of vosA causes a rapid decrease in spore viability. The absence of vosA also results in a lack of trehalose biogenesis and decreased tolerance of ascospores to thermal and oxidative stresses. RNA-seq-based genome-wide expression analysis demonstrated that the loss of vosA leads to elevated expression of sterigmatocystin (ST) biosynthetic genes and a slight increase in ST production in ascospores. Moreover, the deletion of vosA causes upregulation of additional gene clusters associated with the biosynthesis of other secondary metabolites, including asperthecin, microperfuranone, and monodictyphenone. On the other hand, the lack of vosA results in the downregulation of various genes involved in primary metabolism. In addition, vosA deletion alters mRNA levels of genes associated with the cell wall integrity and trehalose biosynthesis. Overall, these results demonstrate that the velvet regulator VosA plays a key role in the maturation and the cellular and metabolic integrity of sexual spores in A. nidulans. Full article
(This article belongs to the Special Issue Omics Studies Focused on Fungal Secondary Metabolism)
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Review

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26 pages, 2765 KiB  
Review
Omics Approaches Applied to Penicillium chrysogenum and Penicillin Production: Revealing the Secrets of Improved Productivity
by Carlos García-Estrada, Juan F. Martín, Laura Cueto and Carlos Barreiro
Genes 2020, 11(6), 712; https://doi.org/10.3390/genes11060712 - 26 Jun 2020
Cited by 20 | Viewed by 7218
Abstract
Penicillin biosynthesis by Penicillium chrysogenum is one of the best-characterized biological processes from the genetic, molecular, biochemical, and subcellular points of view. Several omics studies have been carried out in this filamentous fungus during the last decade, which have contributed to gathering a [...] Read more.
Penicillin biosynthesis by Penicillium chrysogenum is one of the best-characterized biological processes from the genetic, molecular, biochemical, and subcellular points of view. Several omics studies have been carried out in this filamentous fungus during the last decade, which have contributed to gathering a deep knowledge about the molecular mechanisms underlying improved productivity in industrial strains. The information provided by these studies is extremely useful for enhancing the production of penicillin or other bioactive secondary metabolites by means of Biotechnology or Synthetic Biology. Full article
(This article belongs to the Special Issue Omics Studies Focused on Fungal Secondary Metabolism)
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15 pages, 1883 KiB  
Review
Farnesol and Tyrosol: Secondary Metabolites with a Crucial quorum-sensing Role in Candida Biofilm Development
by Célia F. Rodrigues and Lucia Černáková
Genes 2020, 11(4), 444; https://doi.org/10.3390/genes11040444 - 18 Apr 2020
Cited by 55 | Viewed by 7045
Abstract
When living in biological and interactive communities, microorganisms use quorum-sensing mechanisms for their communication. According to cell density, bacteria and fungi can produce signaling molecules (e.g., secondary metabolites), which participate, for example, in the regulation of gene expression and coordination of collective behavior [...] Read more.
When living in biological and interactive communities, microorganisms use quorum-sensing mechanisms for their communication. According to cell density, bacteria and fungi can produce signaling molecules (e.g., secondary metabolites), which participate, for example, in the regulation of gene expression and coordination of collective behavior in their natural niche. The existence of these secondary metabolites plays a main role in competence, colonization of host tissues and surfaces, morphogenesis, and biofilm development. Therefore, for the design of new antibacterials or antifungals and understanding on how these mechanisms occur, to inhibit the secretion of quorum-sensing (e.g., farnesol and tyrosol) molecules leading the progress of microbial infections seems to be an interesting option. In yeasts, farnesol has a main role in the morphological transition, inhibiting hyphae production in a concentration-dependent manner, while tyrosol has a contrary function, stimulating transition from spherical cells to germ tube form. It is beyond doubt that secretion of both molecules by fungi has not been fully described, but specific meaning for their existence has been found. This brief review summarizes the important function of these two compounds as signaling chemicals participating mainly in Candida morphogenesis and regulatory mechanisms. Full article
(This article belongs to the Special Issue Omics Studies Focused on Fungal Secondary Metabolism)
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