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Gels
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Advances in Gels for Wound Treatment
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Advances in Gels for Wound Treatment

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Applications".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 4496

Special Issue Editors

Dr. Md Shaifur Rahman

E-Mail Website
Guest Editor
Institute of Tissue Banking and Biomaterial Research, Atomic Energy Research Establishment, Dhaka 1349, Bangladesh
Interests: stem cells; developmental biology; signaling pathways; tissue engineering; regenerative medicine
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Pasquale Del Gaudio

E-Mail Website
Guest Editor
Department of Pharmacy, University of Salerno, 84084 Fisciano, Italy
Interests: hydrogels; aerogels; controlled drug delivery; wound healing; carbohydrate polymers; microparticles; nanoparticles; nanocomposite; 3D printing
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Gel materials have gained significant attention in recent years due to their unique properties and versatile applications in the biomedical field. These materials, characterized by their ability to swell and retain large amounts of water within their network, offer numerous advantages for various bioengineering applications, including drug delivery, tissue engineering, regenerative medicine, and biosensing. This Special Issue highlights the use of gels as carriers for bioactive agents, including growth factors, antimicrobials, and extracellular matrix components, to promote tissue regeneration, wound healing, and antimicrobial activity. Furthermore, this Special Issue discusses the clinical applications of gel-based wound treatments, such as developing gel-based wound dressings and topical formulations. It evaluates their effectiveness in various wound types, including chronic wounds, burns, and surgical incisions.

This Special Issue provides an excellent platform to present and discuss the design, synthesis, characterization, and utilization of hydrogels and biopolymeric gels and formulation strategies to enhance their properties and effectiveness in wound healing.

This Special Issue comprises original research articles as well as comprehensive reviews, communications, and perspectives and aims to provide a platform to guide future work in this subject matter.

Dr. Md Shaifur Rahman
Prof. Dr. Pasquale Del Gaudio
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • wound treatment
  • wound healing
  • gel biomaterials
  • drug delivery
  • formulation strategies
  • bioactive agents
  • tissue regeneration
  • wound dressings
  • clinical applications

Published Papers (2 papers)

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Research

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20 pages, 4722 KiB  
Article
Human Mesenchymal Stem Cells on Size-Sorted Gelatin Hydrogel Microparticles Show Enhanced In Vitro Wound Healing Activities
by Derya Ozhava, Cemile Bektas, Kathleen Lee, Anisha Jackson and Yong Mao
Gels 2024, 10(2), 97; https://doi.org/10.3390/gels10020097 - 26 Jan 2024
Viewed by 1098
Abstract
The demand for innovative therapeutic interventions to expedite wound healing, particularly in vulnerable populations such as aging and diabetic patients, has prompted the exploration of novel strategies. Mesenchymal stem cell (MSC)-based therapy emerges as a promising avenue for treating acute and chronic wounds. [...] Read more.
The demand for innovative therapeutic interventions to expedite wound healing, particularly in vulnerable populations such as aging and diabetic patients, has prompted the exploration of novel strategies. Mesenchymal stem cell (MSC)-based therapy emerges as a promising avenue for treating acute and chronic wounds. However, its clinical application faces persistent challenges, notably the low survivability and limited retention time of engraftment in wound environments. Addressing this, a strategy to sustain the viability and functionality of human MSCs (hMSCs) in a graft-able format has been identified as crucial for advanced wound care. Hydrogel microparticles (HMPs) emerge as promising entities in the field of wound healing, showcasing versatile capabilities in delivering both cells and bioactive molecules/drugs. In this study, gelatin HMPs (GelMPs) were synthesized via an optimized mild processing method. GelMPs with distinct diameter sizes were sorted and characterized. The growth of hMSCs on GelMPs with various sizes was evaluated. The release of wound healing promoting factors from hMSCs cultured on different GelMPs were assessed using scratch wound assays and gene expression analysis. GelMPs with a size smaller than 100 microns supported better cell growth and cell migration compared to larger sizes (100 microns or 200 microns). While encapsulation of hMSCs in hydrogels has been a common route for delivering viable hMSCs, we hypothesized that hMSCs cultured on GelMPs are more robust than those encapsulated in hydrogels. To test this hypothesis, hMSCs were cultured on GelMPs or in the cross-linked methacrylated gelatin hydrogel (GelMA). Comparative analysis of growth and wound healing effects revealed that hMSCs cultured on GelMPs exhibited higher viability and released more wound healing activities in vitro. This observation highlights the potential of GelMPs, especially those with a size smaller than 100 microns, as a promising carrier for delivering hMSCs in wound healing applications, providing valuable insights for the optimization of advanced therapeutic strategies. Full article
(This article belongs to the Special Issue Advances in Gels for Wound Treatment)
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Review

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21 pages, 3396 KiB  
Review
Hydrogels and Wound Healing: Current and Future Prospects
by Varshan Gounden and Moganavelli Singh
Gels 2024, 10(1), 43; https://doi.org/10.3390/gels10010043 - 05 Jan 2024
Viewed by 2300
Abstract
The care and rehabilitation of acute and chronic wounds have a significant social and economic impact on patients and global health. This burden is primarily due to the adverse effects of infections, prolonged recovery, and the associated treatment costs. Chronic wounds can be [...] Read more.
The care and rehabilitation of acute and chronic wounds have a significant social and economic impact on patients and global health. This burden is primarily due to the adverse effects of infections, prolonged recovery, and the associated treatment costs. Chronic wounds can be treated with a variety of approaches, which include surgery, negative pressure wound therapy, wound dressings, and hyperbaric oxygen therapy. However, each of these strategies has an array of limitations. The existing dry wound dressings lack functionality in promoting wound healing and exacerbating pain by adhering to the wound. Hydrogels, which are commonly polymer-based and swell in water, have been proposed as potential remedies due to their ability to provide a moist environment that facilitates wound healing. Their unique composition enables them to absorb wound exudates, exhibit shape adaptability, and be modified to incorporate active compounds such as growth factors and antibacterial compounds. This review provides an updated discussion of the leading natural and synthetic hydrogels utilized in wound healing, details the latest advancements in hydrogel technology, and explores alternate approaches in this field. Search engines Scopus, PubMed, Science Direct, and Web of Science were utilized to review the advances in hydrogel applications over the last fifteen years. Full article
(This article belongs to the Special Issue Advances in Gels for Wound Treatment)
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