Stimuli-Responsive Biomedical Hydrogels

A special issue of Gels (ISSN 2310-2861).

Deadline for manuscript submissions: closed (30 April 2022) | Viewed by 16284

Special Issue Editors

School of Materials Science and Engineering, Xi'an Jiaotong University, Xi'an 710049, China
Interests: biomedical hydrogels; tissue engineering; conductive scaffold; wound healing
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Guest Editor
School of Basic Medical Science, Southern Medical University, Guangzhou, China
Interests: tissue engineering; hydrogel; 3D printing; electrospinning

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Guest Editor
Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, China
Interests: hydrogels; wound healing; hemostatic agents; soft tissue repair

Special Issue Information

Dear Colleagues,

Since the pioneering work of Wichterle and Lim in 1960 on crosslinked hydroxyethyl methacrylate hydrogels, and because of their hydrophilic character and potential to be biocompatible, hydrogels have been of great interest to biomaterial scientists for many years. Stimuli-responsive hydrogels, responding to physical (temperature, electric field, light, pressure, and magnetic field), chemical (pH and ion) or biological/biochemical stimuli, have been especially impactful, allowing for unprecedented levels of control over material properties in response to external cues. This enhanced control has enabled groundbreaking advances in healthcare, leading to more effective treatment of a vast array of diseases and improved approaches for tissue engineering and wound healing. However, this puts forward higher requirements for its polymer component design, hydrogel network cross-linking method, micro-configuration, and so on. This Special Issue on “Stimuli-Responsive Biomedical Hydrogels” is dedicated to introducing the latest developments in the synthesis, characterization, and biomedical applications of stimuli-responsive hydrogels. In this context, a wide range of topics will be discussed, including novel cross-linking mechanisms, biological effects, and biomedical applications. Although biomedical hydrogels have made important progress in drug/cell delivery, 3D cell culture, 3D bioprinting, tissue engineering, wound healing, and physiological signal monitoring, their research involves multiple disciplines, and scholars with different disciplinary backgrounds need to cooperate closely to promote their application in disease diagnosis, monitoring, and treatment. At present, the development of novel stimuli-responsive hydrogel systems, new characterization methods, and the expansion of biomedical applications still need further exploration and research. Because it is impossible to cover all aspects of stimuli-responsive biomedical hydrogels in one issue, this Special Issue will mainly discuss their new progress in several widely studied application areas to promote the advances of stimuli-responsive hydrogels with a wide range of ideal biological properties. It is hoped that these themes can stimulate new research and discoveries in the field of stimuli-responsive biomedical hydrogels.

Dr. Xin Zhao
Prof. Dr. Yaobin Wu
Dr. Yongping Liang
Guest Editors

Manuscript Submission Information

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Keywords

  • stimuli-responsive biomedical hydrogels
  • novel hydrogel system and characterization techniques
  • tissue repair or tissue engineering
  • drug/cell delivery
  • physiological signal monitoring

Published Papers (5 papers)

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Research

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12 pages, 5077 KiB  
Article
Dual-Responsive Photonic Crystal Sensors Based on Physical Crossing-Linking SF-PNIPAM Dual-Crosslinked Hydrogel
by Wenxiang Zheng, Xiaolu Cai, Dan Yan, Ghulam Murtaza, Zihui Meng and Lili Qiu
Gels 2022, 8(6), 339; https://doi.org/10.3390/gels8060339 - 30 May 2022
Cited by 7 | Viewed by 2326
Abstract
Flexible wearable materials have frequently been used in drug delivery, healthcare monitoring, and wearable sensors for decades. As a novel type of artificially designed functional material, photonic crystals (PCs) are sensitive to the changes in the external environment and stimuli signals. However, the [...] Read more.
Flexible wearable materials have frequently been used in drug delivery, healthcare monitoring, and wearable sensors for decades. As a novel type of artificially designed functional material, photonic crystals (PCs) are sensitive to the changes in the external environment and stimuli signals. However, the rigidity of the PCs limits their application in the field of biometric and optical sensors. This study selects silk fibroin (SF) and poly-N-isopropylacrylamide (PNIPAM) as principal components to prepare the hydrogel with the physical crosslinking agent lithium silicate (LMSH) and is then integrated with PCs to obtain the SF-PNIPAM dual-crosslinked nanocomposite for temperature and strain sensing. The structural colors of the PCs change from blue to orange-red by the variation in temperature or strain. The visual temperature-sensing and adhesion properties enable the SF-PNIPAM dual-crosslinked nanocomposite to be directly attached to the skin in order to monitor the real-time dynamic of human temperature. Based on its excellent optical properties and biocompatibility, the SF-PNIPAM dual-crosslinked nanocomposite can be applied to the field of visual biosensing, wearable display devices, and wound dressing materials. Full article
(This article belongs to the Special Issue Stimuli-Responsive Biomedical Hydrogels)
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13 pages, 2371 KiB  
Article
Metal Complexation of Arabinoxylan Engenders a Smart Material Offering pH, Solvents, and Salt Responsive On–Off Swelling with the Potential for Sustained Drug Delivery
by Syed Nasir Abbas Bukhari, Muhammad Ajaz Hussain, Muhammad Tahir Haseeb, Abdul Wahid, Naveed Ahmad, Syed Zajif Hussain, Rizwan Nasir Paracha, Muhammad Usman Munir and Mervat A. Elsherif
Gels 2022, 8(5), 283; https://doi.org/10.3390/gels8050283 - 2 May 2022
Cited by 4 | Viewed by 2008
Abstract
The present study aimed to develop a stable interconnected matrix as a sustained release drug delivery material. Arabinoxylan (AX) was extracted from ispaghula husk and then crosslinked with different concentrations, i.e., 0.5, 1.0, and 1.5 g of CaCl2 per 0.25 g of [...] Read more.
The present study aimed to develop a stable interconnected matrix as a sustained release drug delivery material. Arabinoxylan (AX) was extracted from ispaghula husk and then crosslinked with different concentrations, i.e., 0.5, 1.0, and 1.5 g of CaCl2 per 0.25 g of AX. The crosslinking was confirmed through Fourier transform infrared spectroscopy. The swelling capacity of crosslinked AX (CL-AX) was evaluated against buffer solutions of pH 1.2, 6.8, 7.4, and water. The swelling capacity increased from pH 1.2 to pH 7.4 and followed the second order swelling kinetics. The swelling study also revealed that CL-AX with 1.0 g CaCl2 showed maximum swelling capacity. The swelling–deswelling (on–off switching) behavior of CL-AX was evaluated in water–ethanol, water–0.9% NaCl solution, and buffer solutions of pH 7.4–1.2 and showed responsive swelling–deswelling behavior. Scanning electron microscopy revealed a highly porous nature of CL-AX with a mesh of thin fibrous networking. Hemocompatibility studies of CL-AX revealed its non-thrombogenic and nonhemolytic attributes. The CL-AX matrix tablet prolonged the release of enalapril maleate for 24 h, and the drug release followed the zero order kinetics and super case-II transport mechanism. Therefore, CL-AX can be recognized as a stimuli responsive and hemocompatible biomaterial with sustained drug release potential. Full article
(This article belongs to the Special Issue Stimuli-Responsive Biomedical Hydrogels)
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14 pages, 4423 KiB  
Article
Super-Adsorptive Biodegradable Hydrogel from Simply Treated Sugarcane Bagasse
by Md. Ibrahim H. Mondal, Md. Obaidul Haque, Firoz Ahmed, Md. Nahid Pervez, Vincenzo Naddeo and Mohammad Boshir Ahmed
Gels 2022, 8(3), 177; https://doi.org/10.3390/gels8030177 - 14 Mar 2022
Cited by 6 | Viewed by 3239
Abstract
There is a great demand for biodegradable hydrogel, and cellulose enriched wastes materials are widely used to serve this purpose for various advance applications (e.g., biomedical and environmental). Sugarcane bagasse is cellulose-enriched agro-waste, abundantly grown in Bangladesh. This study aimed to treat sugarcane [...] Read more.
There is a great demand for biodegradable hydrogel, and cellulose enriched wastes materials are widely used to serve this purpose for various advance applications (e.g., biomedical and environmental). Sugarcane bagasse is cellulose-enriched agro-waste, abundantly grown in Bangladesh. This study aimed to treat sugarcane bagasse-based agro-waste using a sustainable and ecofriendly approach to produce hydrogel with super-swelling capacity for adsorption of copper, chromium, iron ions, methylene blue and drimaren red dyes. To increase the swelling property of hydrogels, copolymerization of hydrophilic monomers is an effective technique. Therefore, this study aimed to prepare hydrogel via free radical graft-copolymerization reaction among acrylamide, methyl methacrylate and treated bagasse in the presence of N,N-methylene-bis-acrylamide as a crosslinker and potassium persulphate as an initiator. To obtain maximum yield, reaction conditions were optimized. It was found that hydrogel obtained from chemically treated sugarcane bagasse showed maximum water absorption capacity of 228.0 g/g, whereas untreated bagassebased hydrogel could absorb ~50 g/g of water. Maximum adsorption capacity of 247.0 mg/g was found for copper ion. In addition, organic pollutant removal from industrial effluent also showed good performance, removing >90% of methylene blue and 62% of drimaren red dye, with shorter kinetics. The biodegradability study showed that after 90 days of exposure, the hydrogels degraded to about 43% of their own mass. Therefore, the produced hydrogel could be an alternative adsorbent to remove pollutants and also for other potential applications. Full article
(This article belongs to the Special Issue Stimuli-Responsive Biomedical Hydrogels)
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Review

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23 pages, 2578 KiB  
Review
Recent Research on Hybrid Hydrogels for Infection Treatment and Bone Repair
by Mengjiao Cao, Chengcheng Liu, Mengxin Li, Xu Zhang, Li Peng, Lijia Liu, Jinfeng Liao and Jing Yang
Gels 2022, 8(5), 306; https://doi.org/10.3390/gels8050306 - 16 May 2022
Cited by 5 | Viewed by 3459
Abstract
The repair of infected bone defects (IBDs) is still a great challenge in clinic. A successful treatment for IBDs should simultaneously resolve both infection control and bone defect repair. Hydrogels are water-swollen hydrophilic materials that maintain a distinct three-dimensional structure, helping load various [...] Read more.
The repair of infected bone defects (IBDs) is still a great challenge in clinic. A successful treatment for IBDs should simultaneously resolve both infection control and bone defect repair. Hydrogels are water-swollen hydrophilic materials that maintain a distinct three-dimensional structure, helping load various antibacterial drugs and biomolecules. Hybrid hydrogels may potentially possess antibacterial ability and osteogenic activity. This review summarizes the recent progress of different kinds of antibacterial agents (including inorganic, organic, and natural) encapsulated in hydrogels. Several representative hydrogels of each category and their antibacterial mechanism and effect on bone repair are presented. Moreover, the advantages and disadvantages of antibacterial agent hybrid hydrogels are discussed. The challenge and future research directions are further prospected. Full article
(This article belongs to the Special Issue Stimuli-Responsive Biomedical Hydrogels)
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26 pages, 7915 KiB  
Review
Poly(N-Isopropylacrylamide) Based Electrically Conductive Hydrogels and Their Applications
by Zexing Deng, Yi Guo, Xin Zhao, Tianming Du, Junxiong Zhu, Youlong Xie, Fashuai Wu, Yuheng Wang and Ming Guan
Gels 2022, 8(5), 280; https://doi.org/10.3390/gels8050280 - 1 May 2022
Cited by 12 | Viewed by 4338
Abstract
Poly(N-isopropylacrylamide) (PNIPAM) based electrically conductive hydrogels (PNIPAM-ECHs) have been extensively studied in recent decades due to their thermal-responsive (leading to the volume change of hydrogels) and electrically conductive performance. The incorporation of conductive components into the PNIPAM hydrogel network makes it become conductive [...] Read more.
Poly(N-isopropylacrylamide) (PNIPAM) based electrically conductive hydrogels (PNIPAM-ECHs) have been extensively studied in recent decades due to their thermal-responsive (leading to the volume change of hydrogels) and electrically conductive performance. The incorporation of conductive components into the PNIPAM hydrogel network makes it become conductive hydrogel, and as a result, the PNIPAM hydrogel could become sensitive to an electrical signal, greatly expanding its application. In addition, conductive components usually bring new stimuli-responsive properties of PNIPAM-based hydrogels, such as near-infrared light and stress/strain responsive properties. PNIPAM-ECHs display a wide range of applications in human motion detection, actuators, controlled drug release, wound dressings, etc. To summarize recent research advances and achievements related to PNIPAM-ECHs, this manuscript first reviews the design and structure of representative PNIPAM-ECHs according to their conductive components. Then, the applications of PNIPAM-ECHs have been classified and discussed. Finally, the remaining problems related to PNIPAM-ECHs have been summarized and a future research direction is proposed which is to fabricate PNIPAM-ECHs with integrated multifunctionality. Full article
(This article belongs to the Special Issue Stimuli-Responsive Biomedical Hydrogels)
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