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Gels
Special Issues
Hydrogel and Membrane Dressings for Antibacterial Applications
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Hydrogel and Membrane Dressings for Antibacterial Applications

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Applications".

Deadline for manuscript submissions: 30 April 2024 | Viewed by 1901

Special Issue Editors

Dr. Chao Zhou

E-Mail Website
Guest Editor
School of Medical and Health Engineering, Changzhou University, Changzhou 213164, China
Interests: gels; antibacterial activity; anti-infection; wound healing; anti-inflammatory
Special Issues, Collections and Topics in MDPI journals
Dr. Yang Liu

E-Mail Website
Guest Editor
School of Medical and Health Engineering, Changzhou University, Changzhou 213164, China
Interests: biomaterials; tissue engineering; surface modification
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Xiubo Zhao

E-Mail Website
Guest Editor
School of Pharmacy & School of Biological and Food Engineering, Changzhou University, Changzhou 213164, China
Interests: antibacterial peptides; drug delivery; bioprinting; biosensors

Special Issue Information

Dear Colleagues,

Skin plays important roles in homeostasis and protects the body from microbial invasion. However, it is highly vulnerable to external damage caused by accident or surgery. Bacterial infections on skin wounds cause significant pains and health issues. Although skin wounds can naturally heal via a four-stage process (hemostasis, inflammation, proliferation, and remodeling), wound treatments are recommended immediately after injury to facilitate wound closure and repair. A wound dressing is commonly used to prevent bacterial infections and promote wound healing. An ideal wound dressing material should be biocompatible, can absorb fluid released from the wound, release various growth factors required for wound healing, and can act as a barrier to prevent further invasions by foreign microorganisms. Antimicrobial hydrogels and membranes are the most popular dressings, and have been widely used in clinical applications. This Special Issue on “Hydrogel and Membrane Dressings for Antibacterial Applications” is dedicated to the recent developments of hydrogels or membrane dressings for wound healing. A broad range of subjects, including the structure of antibacterial dressings, the antibacterial behavior and antibacterial mechanisms of dressings, anti-inflammatory activity of dressings and effect of wound healing, will be discussed. Papers and reviews ranging from theoretical and fundamental aspects to fabrication, characterization, and applications are all welcome. It is hoped that the topics will stimulate new research and discoveries in the field of antimicrobial dressings for wound healing.

Dr. Chao Zhou
Dr. Yang Liu
Prof. Dr. Xiubo Zhao
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hydrogel
  • electrospinning
  • membrane
  • antibacterial activity
  • antibiofilm
  • wound healing
  • anti-inflammation
  • antibacterial polymers
  • angiogenesis
  • chronic wound
  • burn
  • diabetic foot
  • tissue engineering
  • tissue regeneration
  • drug delivery
  • chronic wound
  • bioprinting

Published Papers (2 papers)

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Research

14 pages, 7285 KiB  
Article
In Vitro Antibacterial and Anti-Inflammatory Properties of Imidazolium Poly(ionic liquids) Microspheres Loaded in GelMA-PEG Hydrogels
by Chao Zhou, Mengdi Sun, Danni Wang, Mingmei Yang, Jia Ling Celestine Loh, Yawen Xu and Ruzhi Zhang
Gels 2024, 10(4), 278; https://doi.org/10.3390/gels10040278 - 20 Apr 2024
Viewed by 488
Abstract
Repairing damaged tissue caused by bacterial infection poses a significant challenge. Traditional antibacterial hydrogels typically incorporate various components such as metal antimicrobials, inorganic antimicrobials, organic antimicrobials, and more. However, drawbacks such as the emergence of multi-drug resistance to antibiotics, the low antibacterial efficacy [...] Read more.
Repairing damaged tissue caused by bacterial infection poses a significant challenge. Traditional antibacterial hydrogels typically incorporate various components such as metal antimicrobials, inorganic antimicrobials, organic antimicrobials, and more. However, drawbacks such as the emergence of multi-drug resistance to antibiotics, the low antibacterial efficacy of natural agents, and the potential cytotoxicity associated with metal antibacterial nanoparticles in hydrogels hindered their broader clinical application. In this study, we successfully developed imidazolium poly(ionic liquids) (PILs) polymer microspheres (APMs) through emulsion polymerization. These APMs exhibited notable antibacterial effectiveness and demonstrated minimal cell toxicity. Subsequently, we integrated the APMs into a gelatin methacryloyl (GelMA)—polyethylene glycol (PEG) hydrogel. This composite hydrogel not only showcased strong antibacterial and anti-inflammatory properties but also facilitated the migration of human skin fibroblasts (HSF) and human umbilical vein endothelial cells (HUVECs) and promoted osteogenic differentiation in vitro. Full article
(This article belongs to the Special Issue Hydrogel and Membrane Dressings for Antibacterial Applications)
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16 pages, 3961 KiB  
Article
On-Demand Free Radical Release by Laser Irradiation for Photothermal-Thermodynamic Biofilm Inactivation and Tooth Whitening
by Qi Zhang, Yuan Liu, Meng Ding, Lihui Yuwen and Lianhui Wang
Gels 2023, 9(7), 554; https://doi.org/10.3390/gels9070554 - 07 Jul 2023
Viewed by 1054
Abstract
Dental diseases associated with biofilm infections and tooth staining affect billions of people worldwide. In this study, we combine photothermal agents (MoS2@BSA nanosheets, MB NSs), a thermolysis free-radical initiator (AIPH), and carbomer gel to develop laser-responsive hydrogel (MBA-CB Gel) for biofilm [...] Read more.
Dental diseases associated with biofilm infections and tooth staining affect billions of people worldwide. In this study, we combine photothermal agents (MoS2@BSA nanosheets, MB NSs), a thermolysis free-radical initiator (AIPH), and carbomer gel to develop laser-responsive hydrogel (MBA-CB Gel) for biofilm inactivating and tooth whitening. Under a physiological temperature without laser irradiation, MB NSs can eliminate free radicals generated from the slow decomposition of AIPH due to their antioxidative activity, thereby avoiding potential side effects. A cytotoxicity study indicates that MB NSs can protect mammalian cells from the free radicals released from AIPH without laser irradiation. Upon exposure to laser irradiation, MB NSs promote the rapid decomposition of AIPH to release free radicals by photothermal effect, suggesting their on-demand release ability of free radicals. In vitro experimental results show that the bacteria inactivation efficiency is 99.91% (3.01 log units) for planktonic Streptococcus mutans (S. mutans) and 99.98% (3.83 log units) for planktonic methicillin-resistant Staphylococcus aureus (MRSA) by the mixed solution of MB NSs and AIPH (MBA solution) under 808 nm laser irradiation (1.0 W/cm2, 5 min). For S. mutans biofilms, an MBA solution can inactivate 99.97% (3.63 log units) of the bacteria under similar laser irradiation conditions. Moreover, MBA-CB Gel can whiten an indigo carmine-stained tooth under laser irradiation after 60 min of laser treatment, and the color difference (ΔE) in the teeth of the MBA-CB Gel treatment group was 10.9 times that of the control group. This study demonstrates the potential of MBA-CB Gel as a promising platform for biofilm inactivation and tooth whitening. It is worth noting that, since this study only used stained models of extracted teeth, the research results may not fully reflect the actual clinic situation. Future clinical research needs to further validate these findings. Full article
(This article belongs to the Special Issue Hydrogel and Membrane Dressings for Antibacterial Applications)
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