Advances in Gels for Biomedical Applications

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Applications".

Deadline for manuscript submissions: 20 August 2024 | Viewed by 2685

Special Issue Editor


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Guest Editor
Department of Chemistry, Veer Surendra Sai University of Technology, Burla, Sambalpur 768018, Odisha, India
Interests: hydrogels; nanocomposites; biomedical applications; drug delivery; wound healing; glucose sensing; heavy metals sensing; dye removal

Special Issue Information

Dear Colleagues,

This Special Issue, entitled “Advances in Gels for Biomedical Applications”, is exclusively dedicated to recent advancements in the design, synthesis, and characterization of nanocomposite-based gels for a broad range of biomedical applications including drug delivery, gene therapy, tissue engineering, biosensing, wound healing, bioimaging, dentistry, and pharmaceutical applications.

Well-designed gels possess excellent controllability and functionality, providing versatile platforms for biomedical applications. The high water content, ease of handling, mechanical strength, desirable swelling behavior, and, most importantly, biocompatibility and stimuli sensitivity make the potential application of gels in complex biological environments appealing. When nanoparticles are incorporated into the three-dimensional porous structure of gels, their properties improve towards biological applications as nanomaterials increase their surface area and provide prolonged circulation in blood for effective bioconjugation. Due to the availability of interior networks with properties covering all of the important parameters, hydrogels have proven their suitability in biomedical applications from cost-effective fabrication to effective performance. Several nanomaterials, such as quantum dots, metal nanoparticles, nanorods, nanotubes, nanofibers, nanowires, etc., are combined with polymers, biopolymers, as well as with other nanomaterials and are engineered for the preparation of hydrogels with superior chemical, physical, and biological properties. However, many challenges in this field which restrict the upgradation of nanohydrogels from laboratory to clinical trials for practical real-world implementation still need to be addressed. In this Special Issue, we aim to gather original experimental papers with novel findings along with reviews with adequate logical explanations and critical analyses with regard to several problems and drawbacks associated in this field, with an aspiration to encourage future research and development.

Prof. Dr. Sarat Kumar Swain
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gels
  • nanocomposite hydrogels
  • biomedical applications
  • drug delivery
  • gene therapy
  • tissue engineering
  • wound healing
  • biosensing
  • bioimaging
  • cancer therapy
  • dentistry
  • medicine
  • disease treatment

Published Papers (2 papers)

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Research

14 pages, 4818 KiB  
Article
Agarose Gel Characterization for the Fabrication of Brain Tissue Phantoms for Infrared Multispectral Vision Systems
by Efraín Albor-Ramírez, Miguel Reyes-Alberto, Luis M. Vidal-Flores, Enoch Gutierrez-Herrera and Miguel A. Padilla-Castañeda
Gels 2023, 9(12), 944; https://doi.org/10.3390/gels9120944 - 30 Nov 2023
Cited by 1 | Viewed by 1127
Abstract
Synthetic phantoms that recreate the characteristics of biological tissues are valuable tools for systematically studying and comprehending physiologies, pathologies, and biological processes related to tissues. The reproduction of mechanical and optical properties allows for the development and evaluation of novel systems and applications [...] Read more.
Synthetic phantoms that recreate the characteristics of biological tissues are valuable tools for systematically studying and comprehending physiologies, pathologies, and biological processes related to tissues. The reproduction of mechanical and optical properties allows for the development and evaluation of novel systems and applications in areas such as imaging, optics, ultrasound, or dosimetry, among others. This paper proposes a methodology for manufacturing agarose-based phantoms that mimics the optical properties of healthy brain tissue within the wavelength infrared range of 800 to 820 nm. The fabrication of such phantoms enables the possibility of testing and experimentation in controlled and safe environments toward the design of new near-infrared multispectral imaging systems in neurosurgery. The results of an experimental optical characterization study indicate the validity and reliability of the proposed method for fabricating brain tissue phantoms in a cost-effective and straightforward fashion. Full article
(This article belongs to the Special Issue Advances in Gels for Biomedical Applications)
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9 pages, 863 KiB  
Article
Urinary Electrophoretograms Performed by Capillary Electrophoresis: Comparison between Dogs and Cats
by Laura Gil, Martyna Wsol, Salceda Fernández-Barredo and Paula Fátima Navarro
Gels 2023, 9(7), 544; https://doi.org/10.3390/gels9070544 - 04 Jul 2023
Viewed by 1318
Abstract
Electrophoresis of urine to evaluate different urinary proteins has been used in recent years in veterinary medicine, as it can be a useful laboratory tool in the early detection of kidney damage. However, urinary capillary electrophoresis (UCE) has not been reported in healthy [...] Read more.
Electrophoresis of urine to evaluate different urinary proteins has been used in recent years in veterinary medicine, as it can be a useful laboratory tool in the early detection of kidney damage. However, urinary capillary electrophoresis (UCE) has not been reported in healthy cats. In healthy dogs, reference intervals have been established and can be compared with pathological samples as these provide an easily interpretable pattern. The electrophoretogram in this study is divided into five fractions (F1–F5) by serum (albumin; alpha1-globulin; alpha2-globulin; beta-globulin; and gamma-globulin). Urine samples from 14 healthy cats were obtained by eco-guided cystocentesis. UCE was run in all samples and compared to 123 dog electrophoretograms from a previously published study. Fraction 2 (alpha1-globulin) was statistically decreased in cats (G1) compared to dogs (G2). Fraction 4 (beta-globulin) was statistically augmented in cats compared to the canine population (G2). Fraction 5 (gamma-globulin) was statistically decreased in cats (G1) compared to dogs (G2). No statistical correlation was found between each cat’s serum and urinary fractions. The results of the present study suggest that UCE patterns in cats are similar to the ones described in dogs. UCE can be a non-invasive new diagnostic tool in cats as pathological patterns can be compared to normal ones. Full article
(This article belongs to the Special Issue Advances in Gels for Biomedical Applications)
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