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Biostatistics, Bioinformatics, and Data Analysis

A special issue of Entropy (ISSN 1099-4300). This special issue belongs to the section "Entropy and Biology".

Deadline for manuscript submissions: closed (10 July 2023) | Viewed by 3663

Special Issue Editors


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Guest Editor
1. Department of Bioinformatics and Biostatistics, University of Louisville, Louisville, KY 40202, USA
2. School of Interdisciplinary and Graduate Studies, University of Louisville, Louisville, KY 40292, USA
3. Biostatistics and Bioinformatics Facility, Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
4. Biostatisitcs and Informatics Facility, Center for Integrative Environmental Health Sciences, University of Louisville, Louisville, KY 40202, USA
5. Data Analysis and Sample Management Facility, the University of Louisville Super Fund Center, University of Louisville, Louisville, KY 40202, USA
6. Hepatobiology and Toxicology Center, University of Louisville, Louisville, KY 40202, USA
7. Christina Lee Brown Envirome Institute, University of Louisville, Louisville, KY 40202, USA
Interests: statistics; biostatistics; bioinformatics; clinical trials; behavioral interventions; survival analysis; sampling designs and survey
ICAR-Indian Agricultural Statistics Research Institute, PUSA, New Delhi 110012, India
Interests: statistics; bioinformatics; computational biology; sample survey; computer application; systems biology

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Guest Editor
1. ICAR-Directorate of Foot and Mouth Disease, Arugul, Bhubaneswar 752050, Odisha, India
2. International Center for Foot and Mouth Disease, Arugul, Bhubaneswar 752050, Odisha, India
Interests: statistics; bioinformatics; computational biology; network biology; high-dimensional data analysis

Special Issue Information

Dear Colleagues,

The 21st century is popularly known as the century of data, which are generated through multidisciplinary studies. To extract valuable knowledge from such massive datasets, statistical methodology and data analytic tools have long been employed. Recently, bioinformatics and biostatistics methods and tools have been found to be incredibly helpful in analyzing high-throughput and high-dimensional data obtained from genomic studies. Genomic and clinical studies are particularly complex, characterized by the generation of huge amounts of diverse datasets. Thus, novel statistical methods and bioinformatic tools will be required to address the upcoming challenges in genomic and clinical data analysis.

Therefore, this Special Issue encourages the submission of original works that have statistical rigor in the analysis of data relating to genomics, bioinformatics, proteomics, and clinical studies. These works may also cover a wide range of data on, but not limited to, humans, plants, and other eukaryotes and prokaryotes. We welcome any original and scientific review articles relating, but not limited, to the topics described herein.

Prof. Dr. Shesh Nath Rai
Dr. Anil Rai
Dr. Samarendra Das
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Entropy is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biostatistics
  • bioinformatics
  • high-throughput data
  • high-dimensional data
  • statistical models
  • machine learning
  • genomics
  • clinical survey
  • clinical data

Published Papers (2 papers)

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Research

13 pages, 1627 KiB  
Article
A Note on Cherry-Picking in Meta-Analyses
by Daisuke Yoneoka and Bastian Rieck
Entropy 2023, 25(4), 691; https://doi.org/10.3390/e25040691 - 19 Apr 2023
Cited by 1 | Viewed by 1278
Abstract
We study selection bias in meta-analyses by assuming the presence of researchers (meta-analysts) who intentionally or unintentionally cherry-pick a subset of studies by defining arbitrary inclusion and/or exclusion criteria that will lead to their desired results. When the number of studies is sufficiently [...] Read more.
We study selection bias in meta-analyses by assuming the presence of researchers (meta-analysts) who intentionally or unintentionally cherry-pick a subset of studies by defining arbitrary inclusion and/or exclusion criteria that will lead to their desired results. When the number of studies is sufficiently large, we theoretically show that a meta-analysts might falsely obtain (non)significant overall treatment effects, regardless of the actual effectiveness of a treatment. We analyze all theoretical findings based on extensive simulation experiments and practical clinical examples. Numerical evaluations demonstrate that the standard method for meta-analyses has the potential to be cherry-picked. Full article
(This article belongs to the Special Issue Biostatistics, Bioinformatics, and Data Analysis)
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22 pages, 7519 KiB  
Article
Epileptic Seizure Detection Using Geometric Features Extracted from SODP Shape of EEG Signals and AsyLnCPSO-GA
by Ruofan Wang, Haodong Wang, Lianshuan Shi, Chunxiao Han and Yanqiu Che
Entropy 2022, 24(11), 1540; https://doi.org/10.3390/e24111540 - 26 Oct 2022
Cited by 4 | Viewed by 1458
Abstract
Epilepsy is a neurological disorder that is characterized by transient and unexpected electrical disturbance of the brain. Seizure detection by electroencephalogram (EEG) is associated with the primary interest of the evaluation and auxiliary diagnosis of epileptic patients. The aim of this study is [...] Read more.
Epilepsy is a neurological disorder that is characterized by transient and unexpected electrical disturbance of the brain. Seizure detection by electroencephalogram (EEG) is associated with the primary interest of the evaluation and auxiliary diagnosis of epileptic patients. The aim of this study is to establish a hybrid model with improved particle swarm optimization (PSO) and a genetic algorithm (GA) to determine the optimal combination of features for epileptic seizure detection. First, the second-order difference plot (SODP) method was applied, and ten geometric features of epileptic EEG signals were derived in each frequency band (δ, θ, α and β), forming a high-dimensional feature vector. Secondly, an optimization algorithm, AsyLnCPSO-GA, combining a modified PSO with asynchronous learning factor (AsyLnCPSO) and the genetic algorithm (GA) was proposed for feature selection. Finally, the feature combinations were fed to a naïve Bayesian classifier for epileptic seizure and seizure-free identification. The method proposed in this paper achieved 95.35% classification accuracy with a tenfold cross-validation strategy when the interfrequency bands were crossed, serving as an effective method for epilepsy detection, which could help clinicians to expeditiously diagnose epilepsy based on SODP analysis and an optimization algorithm for feature selection. Full article
(This article belongs to the Special Issue Biostatistics, Bioinformatics, and Data Analysis)
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