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Children
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Heart Failure in Children and Adolescents
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Heart Failure in Children and Adolescents

A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Pediatric Cardiology".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 1804

Special Issue Editors

Dr. Nancy Saad

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Guest Editor
College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA
Interests: heart failure; cardiovascular dysfunctions and complications associated with thyroid gland disorders
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Carl V. Leier

E-Mail Website
Guest Editor
College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA
Interests: heart failure; heart transplant; cardiovascular pharmacology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Pediatric heart failure is a serious and often life-threatening condition in which the heart is no longer able to pump enough blood to meet the body's needs. Some of the most common causes of heart failure in children and adolescents include congenital heart defects, cardiomyopathy, infections, arrhythmia, pulmonary hypertension, and genetic disorders. Since heart failure has different causes and outcomes, it is important to recognize how it is diagnosed, treated, and even cured in younger children.

The costs associated with a heart failure diagnosis are disproportionately high. Both a prolonged hospital length of stay and frequent hospital admissions contribute to high resource utilization in the care of patients with pediatric heart failure. Furthermore, the costs associated with medical care can quickly add up, leading to a significant financial burden for patients and their families. Therefore, there is a pressing need to develop more effective and efficient treatments and management strategies that can help reduce healthcare costs and improve outcomes for children with heart failure.

The aim of this Special Issue is to explore the latest research and advances in the diagnosis, treatment, and management of pediatric heart failure, including the epidemiology and pathophysiology of pediatric heart failure, the latest imaging and diagnostic techniques, and emerging treatment strategies such as mechanical circulatory support and heart transplantation.

This Special Issue also features articles on the impact of pediatric heart failure on patients and their families, including the psychosocial aspects of the disease and the importance of patient and family-centered care.

Other articles focus on quality improvement initiatives in pediatric heart failure care, including efforts to reduce hospital readmissions and improve patient outcomes, as well as the latest research on pediatric heart failure rehabilitation, pediatric cardiac pharmacology, and the role of exercise in the management of the disease.

Given the advances in cardiac development and genetics research on pediatric cardiovascular disease, it is not outside the realm of possibility for a pediatric discovery to be made that will also benefit adults with heart failure.

Overall, this Special Issue on pediatric heart failure aims to provide a comprehensive overview of the latest research and clinical practices in the field and highlights the ongoing efforts to improve outcomes for children with this complex and challenging condition. Contributions related to all aspects of these topics are welcome.

You may choose our Joint Special Issue in Medicina.

Dr. Nancy Saad
Prof. Dr. Carl V. Leier
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiogenetics
  • cardiomyopathy
  • congenital heart disease
  • heart failure
  • heart failure diagnosis
  • heart failure treatment
  • heart transplantation
  • pathophysiology
  • pediatric heart failure and exercise
  • pediatric heart failure and mental health

Published Papers (2 papers)

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Research

11 pages, 425 KiB  
Article
Left Ventricular Longitudinal Strain Abnormalities in Childhood Exposure to Anthracycline Chemotherapy
by Arnaud Rique, Jennifer Cautela, Franck Thuny, Gérard Michel, Caroline Ovaert and Fedoua El Louali
Children 2024, 11(3), 378; https://doi.org/10.3390/children11030378 - 21 Mar 2024
Viewed by 708
Abstract
Current mortality is low in cases of childhood acute leukemia. Dilated cardiomyopathy induced by anthracyclines remains the main cause of morbidity and mortality during mid-term and long-term follow-up. The aim of our study was to analyze the profile of left ventricular alterations in [...] Read more.
Current mortality is low in cases of childhood acute leukemia. Dilated cardiomyopathy induced by anthracyclines remains the main cause of morbidity and mortality during mid-term and long-term follow-up. The aim of our study was to analyze the profile of left ventricular alterations in children treated with anthracyclines and to analyze risks and protective factors, including physical activity. Children and young adults with acute leukemia treated with anthracyclines between 2000 and 2018 during childhood were included. The physical activity performed by the patients before and after treatment was quantified in metabolic equivalent tasks, MET.h, per week. An echocardiographic assessment was performed, including strain analysis. Thirty-eight patients with a median age of 5 [3–8] years were included. Dilated cardiomyopathy was diagnosed in 3 patients and longitudinal strain abnormalities were observed in 11 patients (28.9%). Radiotherapy, cumulative anthracycline doses > 240 mg/m2, and the practice of physical activity > 14 MET.h per week (after leukemia treatment) were independently associated with strain abnormalities. In multivariate analysis, radiotherapy was significantly associated with an increased risk of LV GLS abnormalities (OR = 1.26 [1.01–1.57], p = 0.036), and physical activity > 14 MET.h/week after oncological treatment was significantly associated with a reduction in the risk of LV GLS abnormalities (OR of 0.03 [0.002–0.411], p = 0.009). The strain assessment of left ventricular function is an interesting tool for patient follow-up after leukemia treatment. Moderate and steady physical activity seems to be associated with fewer longitudinal strain abnormalities in patients treated with anthracyclines during childhood. Full article
(This article belongs to the Special Issue Heart Failure in Children and Adolescents)
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20 pages, 1285 KiB  
Article
Long-Term Effects of Child Early Surgical Ventricular Septal Defect Repair on Maternal Stress
by Jennifer Gerlach, Elena S. Decker, Anne-Christine Plank, Stefan Mestermann, Ariawan Purbojo, Robert A. Cesnjevar, Oliver Kratz and Anna Eichler
Children 2023, 10(12), 1832; https://doi.org/10.3390/children10121832 - 21 Nov 2023
Viewed by 786
Abstract
The ventricular septal defect (VSD) represents the most common congenital heart defect (CHD). The diagnosis of and cardiac surgery for their child’s VSD are highly stressful experiences for parents; especially mothers, who are at risk of developing long-lasting stress-related symptoms. This study examined [...] Read more.
The ventricular septal defect (VSD) represents the most common congenital heart defect (CHD). The diagnosis of and cardiac surgery for their child’s VSD are highly stressful experiences for parents; especially mothers, who are at risk of developing long-lasting stress-related symptoms. This study examined long-term alterations in maternal stress including self-reported psychological and biophysiological stress levels in a case-control design. We investigated 24 mothers of children with an isolated, surgically corrected VSD compared to non-affected controls. Maternal self-reports on psychopathology, everyday stress, parenting stress and hair cortisol concentrations (HCC) were measured during children’s primary school age (6–9 years, t1) and early adolescence (10–14 years, t2). In maternal self-reports, psychopathology and stress symptoms in the VSD-group and controls were comparable at t1, whereas at t2, mothers in the VSD-group even showed a decrease in psychopathology. Maternal HCC levels in the VSD-group were significantly lower (hypocortisolism) than HCC levels of controls at t1. This effect was no longer observed at t2 reflecting an approximation of HCC levels in the VSD-group to controls’ levels. This study highlights the potential for improved stress hormone balance and psychological well-being in mothers following their child’s surgical VSD repair. However, the need for parent-centered interventions is discussed, particularly during peri-operative phases and in early child developmental stages. Full article
(This article belongs to the Special Issue Heart Failure in Children and Adolescents)
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